Search results for "Manchester"
showing 10 items of 20 documents
Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in…
2017
Background The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested. Here, we report the results of the second randomisation that addresses the efficacy of myeloablative chemotherapy supported by autologous stem-cell transplantation (ASCT), as an alternative to wh…
Prognostic factors for progression-free and overall survival in advanced biliary tract cancer
2015
BACKGROUND: Biliary tract cancer is an uncommon cancer with a poor outcome. We assembled data from the National Cancer Research Institute (UK) ABC-02 study and 10 international studies to determine prognostic outcome characteristics for patients with advanced disease.METHODS: Multivariable analyses of the final dataset from the ABC-02 study were carried out. All variables were simultaneously included in a Cox proportional hazards model, and backward elimination was used to produce the final model (using a significance level of 10%), in which the selected variables were associated independently with outcome. This score was validated externally by receiver operating curve (ROC) analysis using…
The Open Innovation in Science research field: a collaborative conceptualisation approach
2020
Openness and collaboration in scientific research are attracting increasing attention from scholars and practitioners alike. However, a common understanding of these phenomena is hindered by disciplinary boundaries and disconnected research streams. We link dispersed knowledge on Open Innovation, Open Science, and related concepts such as Responsible Research and Innovation by proposing a unifying Open Innovation in Science (OIS) Research Framework. This framework captures the antecedents, contingencies, and consequences of open and collaborative practices along the entire process of generating and disseminating scientific insights and translating them into innovation. Moreover, it elucidat…
Shape coexistence in Hg-178
2019
Lifetime measurements of excited states in Hg-178 have been performed using the Rh-103(Kr-78, p2n) reaction at a beam energy of 354 MeV. The recoil-decay tagging (RDT) technique was applied to select the Hg-178 nuclei and associate the prompt gamma rays with the correlated characteristic ground-state alpha decay. Lifetimes of the four lowest yrast states of Hg-178 have been determined using the recoil distance Doppler-shift (RDDS) method. The experimental data are compared to theoretical predictions with focus on shape coexistence. The results confirm the shift of the deformed prolate structures to higher lying states but also indicate their increasing deformation with decreasing neutron nu…
Lifetime measurements in 166Re : Collective versus magnetic rotation
2016
WOS: 000371740600004
TPEN: A Triple-foil differential Plunger for lifetime measurements of excited states in Exotic Nuclei
2019
Abstract A Triple-foil differential Plunger for Exotic Nuclei (TPEN) has been developed to measure the lifetimes of excited states in nuclei with small production cross-sections. TPEN utilises one target foil and two degrader foils to make differential lifetime measurements: directly determining the decay function and its derivative at a single plunger distance setting. The direct measurement of the decay function and its derivative removes the requirement to measure γ -ray intensities at several target-to-degrader distances, thereby reducing the beam-time required relative to a conventional plunger with a single-degrader foil. This paper describes the commissioning of TPEN in the lifetime …
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicl…
2018
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines fo…
46 viikkoa pandemian keskellä : vuosien 1918-1919 influenssapandemia Iso-Britanniassa The Manchester Guardianin, The British Medical Journalin ja par…
2016
Tutkimus keskittyy vuosien 1918 - 1919 espanjantautina tunnettuun influenssapandemiaan Iso-Britanniassa kolmen aineistokokonaisuuden: sanomalehti The Manchester Guardianin, lääketieteellisen The British Medical Journal -lehden ja Iso-Britannian parlamentissa käytyjen keskusteluiden kautta. Tarkastelun kohteena on influenssasta poliittisella, professionaalisella, julkisella ja paikallisella tasolla käytyjen keskusteluiden luonne, niiden teemat ja keskusteluissa tapahtuneet muutokset kolmen eri influenssa-aallon aikana, sekä eri tasoilla käytyjen keskusteluiden mahdolliset erot ja yhtäläisyydet. Tutkimus havainnollistaa influenssapandemian yhteiskunnallisten vaikutusten laaja-alaisuutta aina …
Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database.
2020
Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and…
Kansan sankarit : hävittäjälentäjien sankarimyytti ensimmäisessä maailmansodassa ja sen jälkeen
2015
Sotilaslentokone sai tulikasteensa ensimmäisessä maailmansodassa. Lentokoneilla taivaalla sotineet miehet nousivat sodan aikana kansan sankareiksi. Tutkin ensimmäisen maailmansodan hävittäjälentäjien sankarimyyttiä Englannissa ja Saksassa sodan aikana ja sen jälkeen. Tutkin aihetta analysoimalla englantilaisen The Manchester Guardian -lehden ja saksalaisen Freiburger Zeitung -lehden kirjoituksia hävittäjälentäjistä. Tutkin lehdistä vuosia 1915–1924. Analysoin lisäksi kuuden kuuluisan hävittäjälentäjän omaelämäkertoja. Päähuomioni kiinnittyy kysymyksiin: miksi ja miten hävittäjälentäjille luotiin sankaristatusta; miten sankaruus muuttui sodan jälkeen; miten lentäjät kokivat sankaristatuksens…