Search results for "Mania"

Decreased presence of Langerhans cells is a critical determinant for Indian Post kala-azar dermal leishmaniasis.

2015

Post kala-azar dermal leishmaniasis (PKDL) is the dermal sequel of visceral leishmaniasis (VL) and occurs after apparent cure or alongside with VL. It is confined to South Asia (India, Nepal and Bangladesh) and East Africa (mainly Sudan), the incidence being 5-10% and 50-60% respectively. In South Asia, as the transmission of VL is anthroponotic, PKDL patients are the proposed disease reservoir, thus assuming epidemiological significance, its eradication being linked to the control of leishmaniasis. In the absence of an animal model and its low incidence, factors contributing towards the immunopathogenesis of PKDL remain an open-ended, yet pertinent question. This study delineated the lesio…

De minimis curat praetor: Hincmar, le polyptyque de Saint-Remi de Reims et les esclaves de Courtisols

2006

Giles Constable et Michel Rouche; International audience

Il dialogo fra le dogmatiche penali italiana e tedesca alla luce del contributo di Manfred Maiwald

2012

Gladius-bearing coleoids from the Upper Cretaceous Lebanese Lagerstätten: diversity, morphology, and phylogenetic implications.

2017

AbstractGladius-bearing coleoids are rare in the fossil record. For the Cretaceous period, these cephalopods are mainly recorded in a few Lagerstätten in Lebanon (Haqel, Hajoula, En Nammoura, and Sahel Aalma). Here, we study 16 specimens of gladius-bearing coleoids from these Upper Cretaceous Lebanese Lagerstätten to investigate their taxonomic diversity. Besides two species that were already reported (Dorateuthis syriacaandGlyphiteuthis libanotica), one new species is identified in the Cenomanian site of Hajoula:Rachiteuthis acutalin. sp., as well as another form ofGlyphiteuthisfrom En Nammoura. Several studied specimens exhibit well-preserved soft-part characters. Among them, we document …

Taxation in Romania – Some Positive Aspects

2013

Abstract The field of taxation is often a subject of analysis, due to its importance for the formation and administration of public financial resources. By taking into account the local, national and international size of taxation, may be thus identified strengths, weaknesses, opportunities and threats. Although the taxation in Romania is often criticized both by taxpayers and by specialists, there is a progress in taxation field as a result of actions taken in forming and managing fiscal revenues. Without claiming an exhaustive approach, through this article we mention some positive aspects of Romanian taxation. We believe that these should be consolidated and continued.

Liver failure under valproic acid

2011

Valproic acid (VPA, 2-propylvaleric acid) is originally an antiepileptic drug, which has been in use for more than 30 years in over 100 countries. The clinical application of VPA has expanded in the last years. Approval has been granted by the FDA for treatment of migraine and cluster headache in 1996, and for treatment of mania and long-term prophylaxis of bipolar affective disorder in 1995. In ongoing studies, VPA has been reported to inhibit growth of several types of cancer cells; in addition, effects on neurodegeneration, and on virus replication in HIV infection have been demonstrated potentially expanding the application of VPA in the future. Despite a good tolerability of the drug, …

A Hyaluronic acid-pentamidine bioconjugate as macrophage mediated drug targeting delivery system for the treatment of Leishmaniasis

2015

Leishmaniasis is still a serious public health problem worldwide, especially in tropical areas where this infectious disease is endemic. The most severe form of the disease (i.e. visceral) can claim victims if left untreated and the few accessible drugs have several drawbacks including major side effects and parenteral administration. In this context, the investigation of new delivery modalities which might reduce the toxicity and increase the bioavailability of the drugs currently on the market represents a valid strategy to counter these problems. Herein we present the development of a macrophage mediated drug targeting delivery system by conjugating the anti-leishmanial drug pentamidine …

The Current State of Phyto-Coenological Research in the “Iron Gates” Danube Gorge (Banat, Romania)

2014

Abstract The author of the study writes a concise history of the phyto-coenological research conducted previously in the Danube Gorge; he notes the papers and the respective publishing years for the botanists who contributed with research to the knowledge of the cormophyte vegetation along the aforementioned sector of the Danube River. 55 important papers are highlighted, authored by fifty-four specialists in the years 1931-2006.

The Harzburg Management Model in the Contemporary World

2015

Abstract In the context of globalization, economic growth and economic performance is the only chance for Romania. Within all the instruments and means required to obtain the economical growth, a very important role plays the management system, which should be performing and aligned to the requirements and evolution of the contemporary world. An option for a performing management system lies in implementing the German Harzburg Management system within public and private organizations in Romania. The present paper aims to present the main aspects regarding this management model, including main features and performances as a viable alternative to the Romanian management system.

Overview of the pediatric healthcare system in Romania.

2020

Until 1989, Romania was one of the countries of the communist bloc in Europe and its healthcare system was characterized by centralized planning and severe underfunding, with low performance and low quality healthcare. Since 1998, Romania replaced the Semashko model with a social health insurance system, highly centralized under the management of the Ministry of Health as the central administrative authority. After joining the European Union, quality of life increased in our country and there were efforts to improve the quality of healthcare, including pediatric and neonatal care. Still, Romania has the lowest share of health expenditure of gross domestic product among the European Union Me…