Search results for "Mania"
showing 10 items of 710 documents
Contemporary growth studies and Eastern Europe : from scholar debates towards a comparative analysis on Bulgaria, Hungary, Poland and Romania, 1970-1…
2000
Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway.
1997
Cutaneous lesions induced by infection of mice with the protozoan parasite, Leishmania mexicana, contain abundant amounts of a high molecular mass proteophosphoglycan (PPG), which is secreted by the amastigote stage residing in phagolysosomes of macrophages and can then be released into the tissue upon rupture of the infected cells. Amastigote PPG forms sausage-shaped but soluble particles and belongs to a novel class of serine-rich proteins that are extensively O-glycosylated by phosphooligosaccharides capped by mannooligosaccharides. The purified molecule is shown here to efficiently activate complement (C) and deplete hemolytic activity of normal serum and may prevent the opsonization of…
Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major.
2005
Protection against Leishmania major is dependent on IL-12 release from L. major-infected dendritic cells (DC) that induce IFN-gamma-producing Th1/Tc1 cells. IL-27, a novel member of the IL-12 family, is a heterodimer composed of p28 and IL-12p40-related Epstein-Barr virus-induced gene 3 (EBI3), and was shown to be produced by DC. In this study, we utilized EBI3-deficient mice to investigate the role of IL-27 in leishmaniasis using physiological low-dose infections that mimic natural transmissions. Lesions in EBI3(-/-) mice were significantly larger between weeks 3 and 10 post infection, reaching up to approximately threefold increased lesion volumes compared to wild types. In parallel, derm…
THE IMPACT OF THE INDUSTRIALIZATION PROCESS ON THE OTHERS SECTORS OF THE ROMANIAN ECONOMY.THE DYNAMIC ESTABLISHED BETWEEN INDUSTRY AND AGRICULTURE (1…
2012
Once obtained its independence, Romania began a vast process of rebuilding its economy on new bases. The main interest was focused on developing a national industry, the industrialization process representing one of the most significant chapters of the Romanian economic history, as well as of the history of the national economic thought. Placing/considering the industry as the center of the economic system came to invalidate the theory of a "signally agrarian Romania", marking the beginnings of a diversification concerning the structure of the Romanian economy. Although the industrialization constituted an unquestionable premise of the modernization of the economy, the Romanian society and …
Youth Migration Aspirations in Georgia and Moldova
2018
This study investigates in what ways individual and household capabilities and their general life aspirations affect migration aspirations in particular, among Georgian and Moldovan youth. The utilized sample was extracted from nationally representative surveys and considers youth aged 11 to 19 (N=3,583). Multi-level, step-wise probit models are used to predict youth migration aspirations. Among the findings are that individual capabilities, aspirations, and household capabilities significantly impact youth migration aspirations, while household aspirations are statistically insignificant. The results further emulate the importance of residential satisfaction, the effects of gendered social…
Fever with perinasal and tongue lesions: A diagnostic challenge
2023
The diagnosis may be challenging, and high suspicion index should be maintained in immunosuppressed patients with unusual mucocutaneous lesions, even in non-endemic areas for mucocutaneous leishmaniasis.
Heterocyclic Diamines with Leishmanicidal Activity.
2021
Leishmaniasis is one of the world's most neglected diseases with a worldwide prevalence of 12 million people. There are no effective human vaccines for its prevention, and outdated drugs hamper treatment. Therefore, research aimed at developing new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, here, we present 10 new compounds made up by linking alkylated ethylenediamine units to pyridine or quinoline heterocycles with promising in vitro and in vivo efficacy against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani, and Leishmania braziliensis species. Three compounds (2, 4, and 5) showed a selectivity index muc…
Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives
2019
:In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities.:The present review with 411 references, in which we focused on the literatur…
Water striders (Heteroptera: Gerromorpha: Gerridae) of Romania with an update on the distribution of Gerris gibbifer and G. maculatus in southeastern…
2018
The Romanian fauna comprises two species of Aquarius Schellenberg, 1800, eight species of Gerris Fabricius, 1794 and one species of Limnoporus Stål, 1868, and we hereby update the distribution and provide insights on the phenology and ecology of all eleven species in this country. We furthermore update the distribution of the two closely related species Gerris gibbifer Schummel, 1832 and G. maculatus Tamanini, 1946 in southeastern Europe. Gerris maculatus is recorded for the first time from Hungary, Montenegro and Slovenia, and the first detailed localities from Romania and Serbia are given. All bibliographic records of G. gibbifer from Romania, Macedonia and Serbia are based on misidentifi…