Search results for "Mania"
showing 10 items of 710 documents
Translations of Novels in the Romanian Culture During the Long Nineteenth Century (1794-1914): A Quantitative Perspective
2020
This article uses quantitative methods to provide a macro perspective on translations of novels in Romanian culture during the long nineteenth century, by modifying Eric Hobsbawm’s 1789-1914 period, and using it as spanning from 1794 (the first registered local publishing of a translated novel) to 1918 (the end of the First World War). The article discusses the predominance of the French novel (almost 70% of the total of translated novels), the case of four other main competitors in the second line of translations (or the golden circle, as named in the article: German, English, Russian, and Italian), the strange case of the American novel as a transition zone, and the situation of five othe…
A Quantitative Analysis of the Romanian Translations of Shakespeare’s Bawdy Puns
2020
This article proposes a quantitative analysis of the Romanian translations of 325 ribald Shakespearean puns, which originate in 20 plays and 71 renditions, with special focus on assessing the impact of translator-subjective and objective factors on the rendition process in the pre-communist, communist, and post-communist periods. The findings invalidate several widespread beliefs: Dragoș Protopopescu’s renditions, banned by the communist regime for their ‘modernizing’ approach to the Shakespearean text, bowdlerized more bawdy puns than ‘ESPLA’, which replaced it as the Party-approved Romanian edition of the dramatist’s plays; Adolphe Stern’s translations, harshly criticized in his period, f…
Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice
2019
Abstract Objectives To identify the variables that are associated with persistence to Aripiprazole-Long Acting (A-LAI), in adult patients with schizophrenia. Methods Observational, retrospective, non-interventional study involving 261 patients with schizophrenia. Results Eighty-six percent of study subjects were persistent for at least 6 months. All subjects with baseline CGI-S of 1 or 2, 95% of subjects with CGI-S of 3, 86% with CGI-S of 4, 82% of subjects with CGI-S of 5, 73% of subjects with CGI of 6 and 90% of subjects with CGI of 7 were persistent. A-LAI treatment continuation rate was higher in patients with: 1) baseline CGI score ≤ 4; 2) schizophrenia dimension (LDPS) mania score ≤ 5…
Triazolopyridopyrimidines: an emerging family of effective DNA photocleavers. DNA binding. Antileishmanial activity.
2015
Triazolopyridopyrimidines 3-phenyl-6,8-di(2-pyridyl)-[1,2,3]triazolo[5',1':6,1]pyrido[2,3-d]pyrimidine (1a), 6,8-di(pyridin-2-yl)-[1,2,3]triazolo[1',5':1,6]pyrido[2,3-d]pyrimidine (1b) and 3-methyl-6,8-di(2-pyridyl)-[1,2,3]triazolo[5',1':6,1]pyrido[2,3-d]pyrimidine (1c) were prepared and their electrochemical and luminescence properties were studied in depth. The DNA binding ability of this series of compounds has been investigated by means of UV-vis absorption and fluorescence titrations, steady-state emission quenching with ferrocyanide as well as viscosity measurements. Results have shown that triazolopyridopyrimidine 1a interacts strongly at DNA grooves. This compound also displays pref…
In vitro activity of scorpiand-like azamacrocycle derivatives in promastigotes and intracellular amastigotes of Leishmania infantum and Leishmania br…
2012
The activity of a family scorpiand-like azamacrocycles against Leishmania infantum and Leishmania braziliensis was studied using promastigotes, axenic and intracellular amastigotes forms. All the compounds are more active and less toxic than meglumine antimoniate (Glucantime). Moreover, the data on infection rates and amastigotes showed that compounds P2Py, PN and P3Py are the most active against both species of Leishmania. On the other hand, studies on the inhibitory effect of these compounds on SOD enzymes showed that while the inhibition of the Fe-SOD enzyme of the promastigote forms of the parasites is remarkable, the inhibition of human CuZn-SOD and Mn-SOD from Escherichia coli is negl…
Statistical Analysis of the Indicators that have Influenced the Standard of Living in Romania During the Economic Crisis
2015
Abstract As all the countries in the world, Romania is going through a period of large and deep economic, financial and social changes. The negative effects of the economic crisis are well known: Increase of unemployment rate, sharp decrease of incomes because of the imposed political measures and decrease of purchasing power resulting in a decrease of the quality of life. The quality of life may be assessed based on several macroeconomic indicators, such as: GD per capita, population incomes or expenses, population consumption, indicators that are the foundation of the analyses that may help taking decisions regarding the social and economic policies aimed to the increase of the standard o…
Do Fiscal Rules Constrain Fiscal Policy in Romania?
2020
At both macroeconomic and national level, in recent decades, European tax policies have shown a particular interest in addressing the spectrum of risk issues in terms of maturing the business environment and the lack of sustainable development of the economy. In Romania there has been a significant increase in public debt, which is increasingly threatening fiscal sustainability. This is due to fiscal rules that restrict the applicability of fiscal policy to balancing the national economy. However, fiscal policy did not act in the direction of economic recovery during the crisis that started in the last quarter of 2008, which had a negative impact on the Romanian business environment. Object…
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities
2011
Four new tetromycin derivatives, tetromycins 1-4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001(T) cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV M(pro), and PL(pro). The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteas…
Inefficiency of emotion regulation as vulnerability marker for bipolar disorder: evidence from healthy individuals with hypomanic personality.
2012
Abstract Objective Emotion regulation deficits are a key characteristic of bipolar disorder (BD). In the present study, we asked if deficits in emotion regulation are also a vulnerability marker for BD. To this end, we investigated a healthy group of participants at high-risk for developing BD, defined on the basis of a hypomanic personality trait. We examined the neural correlates of two emotion regulation strategies, reappraisal and distraction. Method Twenty-two individuals with higher risk for BD and twenty-four controls were investigated in a functional magnetic resonance imaging paradigm. Participants were presented with negative, positive and neutral pictures and were either required…
A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
2001
Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of approximately 1% in all human populations. In order to identify chromosomal regions containing genes that play a role in determining susceptibility to this psychiatric condition, we have conducted a complete genome screen with 382 markers (average marker spacing of 9.3 cM) in a sample of 75 BPAD families which were recruited through an explicit ascertainment scheme. Pedigrees were of German, Israeli and Italian origin, respectively. Parametric and non-parametric linkage analysis was performed. The highe…