Search results for "Manta"
showing 10 items of 148 documents
CCDC 2041028: Experimental Crystal Structure Determination
2021
Related Article: Goulielmina Anyfanti, Antonio Bauzá, Lorenzo Gentiluomo, João Rodrigues, Gustavo Portalone, Antonio Frontera, Kari Rissanen, Rakesh Puttreddy|2021|Frontiers in Chemistry|9||doi:10.3389/fchem.2021.623595
A Stage-Based Approach to Therapy in Parkinson’s Disease
2019
Parkinson’s disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor symptoms, including depression, REM sleep behavior disorder, and olfactive impairment, are even earlier features of PD. At later stages, apathy, impulse control disorder, neuropsychiatric disturbances, and cognitive impairment can present, and they often become a heavy burden for both patients and caregivers. Indeed, PD increasingly compromises activities of daily life, even though a high variability in clinical presentation can be observed among people affected. Nowadays, symptomatic drugs and non-phar…
Combination therapy with amantadine and interferon in naı̈ve patients with chronic hepatitis C: meta-analysis of individual patient data from six cli…
2003
Abstract Background/Aims In chronic hepatitis C, clinical trials evaluating the efficacy of amantadine (AMA) and interferon (INF) compared to INF monotherapy, have produced conflicting results. We performed a meta-analysis of the individual patient's data from previous studies. Methods Nine hundred and seventy-two patients from six European centres were evaluated by means of individual patient meta-analysis, using mixed models with centres and the centre–treatment interaction fitted as random variables. Results At the end of therapy, virological responses were 38.5% (95% CI 34.1–42.8) after INF and AMA, and 29.5% (95% CI 25.5–33.6) after INF alone (P=0.003). Sustained response occurred in 1…
Chemical Composition of Essential Oils from Athamanta sicula
2008
The genus Athamanta L. (Apiaceae) consists of about nine species, which are distributed mainly in southeastern Europe. Some of the Athamanta species are used in traditional medicine as antiseptics, diuretics, and in the therapy of sclerosis [1]. Phytochemical studies of species from the genus Athamanta report the presence of coumarins [2–5], flavonoids [6], and fatty acids [7]. Athamanta sicula L. is an annual perennial herb, growing to a height of 30 to 100 cm. It occurs in calcareous vertical cliffs 100 meters to 1500 meters above sea level and is widespread in South Italy, particularly in Sicily. In the popular medicine, it is known as “spaccapietre” (rock splitters), and infusions of it…
Aliciklisko alfa-aminoskābju sintēze
2017
Aliciklisko α-aminoskābju sintēze. Stamberga D., zinātniskie vadītāji Dr.chem. Kauss V. un Dr.h.chem., prof. Zicmanis A. Maģistra darbs, 52 lappuses, 36 attēli, 4 tabulas, 48 literatūras avoti. Latviešu valodā. Maģistra darbā ir apskatītas dažādas bi- un tri-(ali)ciklisko α-aminoskābju sintēžu metodes, kā arī dots ieskats enantioselektīvā Dīlsa-Aldera ciklopievienošanās reakcijā biciklo[2.2.1]heptēna fragmenta sintēzei. Literatūras apskatā apkopota informācija par laika periodu no 1973. līdz 2017. gadam, izmantojot datubāzes SciFinder un Espacenet. Darba gaitā izstrādāta metode (R) un (S)-3-(adamantan-1-il)-2-((treš-butoksikarbonil)amino)propānskābju sintēzei četrās stadijās, (1R,2S,4S)-2-(…
Behavioural and pharmacological characterization of a novel cannabimimetic adamantane-derived indole, APICA, in C57BL/6J mice
2015
The novel adamantane derivative APICA (N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide) was recently identified as a cannabimimetic indole of abuse (1, 2). Despite its novel structure, APICA recalls cannabimimetic indoles, such as representative member JWH-018. The emerging abuse problem, together with the paucity of information about the bioactivity of APICA (3) emphasize the need for further evaluation of the in vivo pharmacology of this novel indole-derived compound. In the present study, the effects of APICA (0 - 1 - 3 mg/Kg, i.p.) were tested in C57BL/6J mice, in a battery of tests that are sensitive to the effects of psychoactive cannabinoids, including body temperature; locomotor a…
Bezmantnieku mantas problēmjautājumi teorijā un praksē
2022
Mantojuma tiesības regulē mantas pāreju citam tiesību subjektam pēc personas nāves, nododot arī no tās izrietošās saistības. Mantojuma tiesisko attiecību noregulēšana nav vienkārša, jo nereti mantinieku nav un manta kļūst piekritīga valstij. Ievērojot bezmantinieku mantas institūta nozīmi civiltiesiskās apgrozības nodrošināšanā un sarežģīto raksturu, darba mērķis ir veikt tā padziļinātu izpēti un konstatēt ar to saistīto problemātiku gan normatīvajā regulējumā, gan praksē. Darba uzdevumi ir analizēt tiesību aktus, doktrīnu, tiesu praksi un apzināt esošo situāciju praksē. Darba ietvaros tiek piedāvāti grozījumi Civillikuma 416.pantā, 659.pantā, 694.pantā, 697.pantā, Notariāta likuma 306.pant…
Effect of vildagliptin compared to glimepiride on postprandial proinsulin processing in the β cell of patients with type 2 diabetes mellitus
2012
This study compared the effect of Glimepiride versus Vildagliptin on β-cell function and the release of intact proinsulin (PI) in patients with type 2 diabetes mellitus. Patients on metformin monotherapy were randomized to add on treatment with Vildagliptin or Glimepiride. A standardized test meal was given at baseline, after 12 and 24 weeks of treatment. Insulin, PI and blood glucose values were measured in the fasting state and postprandial for 300 min. Fasting PI levels significantly decreased in the Vildagliptin group. The area under the curve for the postprandial release of PI decreased during Vildagliptin and increased during Glimepiride treatment. The proinsulin to insulin ratio decl…
Il contributo di Calonghi all'innovazione della scuola con la ricerca e la sperimentazione
2014
Calonghi ha messo a punto una metodologia di ricerca in educazione adeguata alle caratteristiche della scuola italiana. La sua attività scientifica copre un arco temporale di circa cinquanta anni.E' possibile enunciare i principi ispiratori dell'innovazione didattica ricavandoli dalla vasta produzione scientifica di Calonghi. Si discute sull'attualità della sua metodologia di ricerca nell'attuale contesto culturale.
Kopīgās mantas sadale laulības šķiršanas lietā.
2017
Laulātie laulības laikā var iegūt īpašumā dažādas mantiskas vērtības, turklāt šīs mantiskās vērtības var piederēt abiem laulātajiem kopīgi. Šķirot laulību, laulāto starpā tiek sadalīta arī abu laulāto kopīgā manta, turklāt mantas sadalījums starp laulātajiem var būt atšķirīgs. Tieši tāpēc laulāto kopīgās mantas sadales jautājums ir nozīmīgs abiem laulātajiem un sabiedrībai kopumā. Laulāto kopīgās mantas sadales institūts ietver vairākus aspektus gan no materiālo tiesību un procesuālo tiesību nomām, gan arī no judikatūras viedokļa. Līdz ar to ir svarīgi šos elementus izpētīt, lai saprastu kopīgās mantas sadales būtību un procesu. Darbā tiek izpētīts laulāto kopīgās mantas sadales institūts L…