Search results for "Mantle"
showing 10 items of 322 documents
Ibrutinib Vs Temsirolimus: Results from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantl…
2015
Abstract Introduction MCL is an aggressive B-cell lymphoma with a poor overall prognosis. For patients who fail initial therapy, conventional chemotherapy achieves only short-term remissions. Ibrutinib is a first-in-class, once-daily, oral, covalent inhibitor of Bruton's tyrosine kinase that has been shown to be highly active for previously treated MCL patients (overall response rate [ORR] ~65%; complete response [CR] ~20%) in single-arm phase 2 studies. Temsirolimus has demonstrated significantly longer progression-free survival (PFS) vs investigator's choice. In this phase 3, randomized, open-label study (MCL3001 [RAY]), ibrutinib was compared with temsirolimus in patients with relapsed o…
Long-Term Outcomes with Ibrutinib Versus the Prior Regimen: A Pooled Analysis in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) with up to 7.5 …
2019
Introduction In MCL, progression-free survival (PFS) generally declines with each successive line of chemoimmunotherapy (CIT). We have previously published that with ibrutinib, a first-in-class oral inhibitor of Bruton's tyrosine kinase and a standard of care treatment (tx) for R/R MCL, median PFS exceeded 2 years (yrs) when used at first relapse (Rule S, et al. Haematologica. 2018;104:e211-e214). Here we present an updated pooled analysis with 15 months (mos) of additional follow-up, and for the first time, a comparison of outcomes with ibrutinib versus the prior regimen. Methods Patients (pts) enrolled in SPARK (MCL2001; NCT01599949), RAY (MCL3001; NCT01646021), and PCYC-1104 (NCT01236391…
Lymphoma Symptoms: Data from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantle Cell Lymp…
2015
Abstract Introduction MCL is an incurable aggressive B-cell lymphoma with a poor overall prognosis. For patients with MCL who fail initial therapy (ie, with relapsed or refractory [R/R] disease), treatment options historically have been limited. While remission duration is generally short, the goal of therapy has been to achieve remission while balancing treatment-related toxicities. Consequently, a substantial proportion of patients continuously suffer from lymphoma symptoms and other disease signs, such as itching and trouble sleeping or concentrating. Additionally, worries and high emotional sensitivity lead to reduced functional status and well-being. Therefore, it is crucial to any tre…
Potassic and sodic igneous rocks from eastern Paraguay: their origin from the lithospheric mantle and genetic relationships with the associated Paran…
1997
3 DIPARTIMENTO DI SCIENZE DELLA TERRA, UNIVERSITY OF TRIESTE, VIA E. WEISS 8, I-34127 TRIESTE, ITALY 4 INSTITUTO DE GEOCIENCIAS, UNIVERSIDADE DE SAO PAULO, C.P. 30627, 01051 SAO PAULO, SP, BRAZIL 5 DIPARTIMENTO DI SCIENZE DELLA TERRA, ‘LA SAPIENZA’ UNIVERSITY, PIAZZALE ALDO MORO 5, I-00185, ROME, ITALY 6 ISTITUTO DI MINERALOGIA, PETROGRAFIA E GEOCHIMICA, UNIVERSITY OF PALERMO, VIA ARCHIRAFI 36, I-90100,
Stability and nature of the volume collapse of ε-Fe2O3 under extreme conditions
2018
Iron oxides are among the major constituents of the deep Earth’s interior. Among them, the epsilon phase of Fe2O3 is one of the less studied polymorphs and there is a lack of information about its structural, electronic and magnetic transformations at extreme conditions. Here we report the precise determination of its equation of state and a deep analysis of the evolution of the polyhedral units under compression, thanks to the agreement between our experiments and ab-initio simulations. Our results indicate that this material, with remarkable magnetic properties, is stable at pressures up to 27 GPa. Above 27 GPa, a volume collapse has been observed and ascribed to a change of the local env…
Potassium-rich magmatism from a phlogopite-free source
2017
The generation of strongly potassic melts in the mantle is generally thought to require the presence of phlogopite in the melting assemblage. In the Mediterranean region, trace element and isotope compositions indicate that continental crustal material is involved in the generation of many potassium-rich lavas. This is clearest in ultrapotassic rocks like lamproites and shoshonites, for which the relevant chemical signals are less diluted by extensive melting of peridotite. Furthermore, melting occurs here in young lithosphere, so the continental crust was not stored for a long period of time in the mantle before reactivation. We have undertaken two types of experiments to investigate the r…
Tertiary Ultrapotassic Volcanism in Serbia: Constraints on Petrogenesis and Mantle Source Characteristics
2005
The Serbian province of Tertiary ultrapotassic volcanism is related to a post-collisional tectonic regime that followed the closure of the Tethyan Vardar Ocean by Late Cretaceous subduction beneath the southern European continental margin. Rocks of this province form two ultrapotassic groups; one with affinities to lamproites, which is concentrated mostly in the central parts of the Vardar ophiolitic suture zone, and the other with affinities to kamafugites, which crops out in volcanoes restricted to the western part of Serbia. The lamproitic group is characterized by a wide range of Sr/Sri (0 70735–0 71299) and Nd/Ndi (0 51251–0 51216), whereas the kamafugitic group is isotopically more ho…
Constraints on the sources of post-collisional K-rich magmatism: The roles of continental clastic sediments and terrigenous blueschists
2017
Abstract The possible role of continental sediments in the generation of potassium-enriched lavas of the Alpine-Himalayan belt depends on their melting behaviour either during subduction or during post-collisional relaxation. Although usually classed as orogenic lavas, these volcanic rocks may result from re-melting of newly formed mantle lithosphere 30–40 million years after collision ends, and can thus be considered as the first stage of intraplate volcanism. The potassic component in these volcanics is characterized by a high Th/La signature for which there are two competing explanations: melting of subducted continental clastic sediments, and the involvement of lawsonite blueschists in …
Chemical heterogeneities in the mantle: The equilibrium thermodynamic approach
2016
Abstract This study attempts to answer a simple and yet fundamental question in relation to our understanding of the chemical evolution of deep Earth and planetary interiors. Given two initially separate assemblages (lithologies) in chemical equilibrium can we predict the chemical and mineralogical compositions of the two assemblages when they are put together to form a new equilibrated system? Perhaps a common perception is that given sufficient time, the two assemblages will homogenize chemically and mineralogically, however from a chemical thermodynamic point of view, this is not the case. Certain petrological differences in terms of bulk composition, mineralogy and mineral abundance rem…
Hydrothermal origin and age of jadeitites from Sierra del Convento Mélange (Eastern Cuba)
2012
Jadeitite (jadeite jade) from Sierra del Convento (eastern Cuba) occurs in a subduction-related serpentinite-matrix melange associated with a variety of high-pressure tectonic blocks including garnet-amphibolites and related anatectic trondhjemites. The eastern Cuban jadeitite is massive and characterized by rare quartz inclusions and omphacite exsolution in jadeite crystals, as well as replacement or infilling by omphacite. Minor minerals include epidote, biotite, albite, phengite, titanite, rutile, zircon, and apatite. Oscillatory zoning in jadeite crystals and zircon ages suggest hydrothermal crystallization in veins formed in serpentinized peridotite, probably of the mantle wedge. Al-Na…