Search results for "Map"
showing 10 items of 3484 documents
HENSTOCK INTEGRAL AND DINI-RIEMANN THEOREM
2009
In [5] an analogue of the classical Dini-Riemann theorem related to non-absolutely convergent series of real number is obtained for the Lebesgue improper integral. Here we are extending it to the case of the Henstock integral.
What is a physical measure of spatial inhomogeneity comparable to the mathematical approach?
1999
A linear transformation f(S) of configurational entropy with length scale dependent coefficients as a measure of spatial inhomogeneity is considered. When a final pattern is formed with periodically repeated initial arrangement of point objects the value of the measure is conserved. This property allows for computation of the measure at every length scale. Its remarkable sensitivity to the deviation (per cell) from a possible maximally uniform object distribution for the length scale considered is comparable to behaviour of strictly mathematical measure h introduced by Garncarek et al. in [2]. Computer generated object distributions reveal a correlation between the two measures at a given l…
Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
2006
Objective To summarize the effects of novel hormones (leptin, ghrelin, adiponectin, resistin, and PYY3-36) secreted from adipose tissue and the gastrointestinal tract that have been discovered to exert different effects on several reproductive functions, such as the hypothalamic–pituitary–gonadal axis, embryo development, implantation physiology, and clinically relevant conditions. Design A MEDLINE computer search was performed to identify relevant articles. Result(s) Leptin and ghrelin exert important roles on body weight regulation, eating behavior, and reproduction, acting on the central nervous system and target reproductive organs. As a marker of adequate nutritional stores, these horm…
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target.
2014
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous pathways. The leptin receptor (Ob-R) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream, and under normal circumstances, circulating levels are proportionate to the fat body mass. Sensing of elevated leptin levels by the hypothalamic neurocircutry activates a negative feedback loop resulting in reduced food intake and increased energy expenditure. Decreased concentrations lead to opposite effects. Therefore rational design of leptin agonists constitute an appealing challenge in the battle against ob…
Monoclonal anti-fosB antibody specific for predetermined, nonstructural region of the fosB protein.
1997
Comparison of the primary structures and theoretical prediction of the potential antigenic determinant of the deduced Fos proteins reveals the presence of a nonstructural and hydrophilic region juxtaposed to the leucine zipper and nonconserved among the Fos protein family. To develop monoclonal anti-peptide antibodies capable of distinguishing all Fos-proteins, synthetic peptides specific for the mentioned predicted region were synthesized manually by the "tea-bag" method. Immunization of Balb/c mice with fosB-related synthetic peptide BSA gave rise to mouse hybridoma cell line K21 (IgG1, kappa) secreting highly specific antibodies against corresponding human fosB protein. Fine mapping of t…
Time-variations of zeroth-order vegetation absorption and scattering at L-band
2021
Abstract Surface soil moisture and vegetation optical depth (VOD), as an indicator of vegetation wet biomass, from passive microwave remote sensing have been increasingly applied in global ecology and climate research. Both soil moisture and VOD are retrieved from satellite brightness temperature measurements assuming a zeroth order radiative transfer model, commonly known as the tau-omega model. In this model the emission of a vegetated surface is dependent on soil moisture, vegetation absorption and vegetation scattering. Vegetation scattering is normally represented by the single scattering albedo, ω, and is commonly assumed to be a time-invariant calibration parameter to achieve high ac…
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance
2020
Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed. Methods: We deprived HCC cells of glutamine to induce metabolic alterations and performed various assays, including metabolomics (with 13C-glucose isotope tracing), microarray analysis, and cell proliferation assays. Glutamine-deprived cells were also treated with kinase inhibitors (e.g. Sorafenib, Erlotinib, U0126 amongst other MEK inhibitors). …
Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of …
2016
During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity-related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during th…
Absence of Sex Differential Plasticity to Light Availability during Seed Maturation in Geranium sylvaticum
2015
Sex-differential plasticity (SDP) hypothesis suggests that since hermaphrodites gain fitness through both pollen and seed production they may have evolved a higher degree of plasticity in their reproductive strategy compared to females which achieve fitness only through seed production. SDP may explain the difference in seed production observed between sexes in gynodioecious species in response to resource (nutrients or water) availability. In harsh environments, hermaphrodites decrease seed production whereas females keep it relatively similar regardless of the environmental conditions. Light availability can be also a limiting resource and thus could theoretically affect differently femal…
Millaiseksi koulu koetaan? : koulukokemuksia Liikkuva koulu -hankkeen kouluista
2012
Ingerttilä, Mari & Jokikokko, Katja. 2012. Millaiseksi koulu koetaan? Koulukokemuksia Liikkuva koulu -hankkeen kouluista. Liikuntapedagogiikan pro gradu -tutkielma. Liikuntatieteiden laitos. Jyväskylän yliopisto. 96 s. Tutkimuksen tavoitteena oli selvittää, eroavatko oppilaiden koulukokemukset pienissä ja isoissa kouluissa, ala- ja yläkouluissa sekä tytöillä ja pojilla. Lisäksi tutkimme, onko oppilaiden fyysisellä aktiivisuudella yhteyttä heidän koulukokemuksiinsa sekä vertai-limme koulukokemuksia syksyn ja kevään välillä. Tutkimus oli osana Liikkuva koulu -hanketta, ja siihen osallistui hankkeen 23 koulun 4.–9. luokkien oppilaat. Tutkimus to-teutettiin määrällisenä pitkittäistutkimuksena. …