Search results for "Map"
showing 10 items of 3484 documents
Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour
2014
Abstract Background To explore the activity of pazopanib in solitary fibrous tumour (SFT). Patients and methods In a preclinical study, we compared the activity of pazopanib, sorafenib, sunitinib, regorafenib, axitinib and bevacizumab in a dedifferentiated-SFT (DSFT) xenotransplanted into Severe Combined Immunodeficiency (SCID) mice. Antiangiogenics were administered at their reported optimal doses when mean tumour volume (TV) was 80 mm3. Drug activity was assessed as TV inhibition percentage (TVI%). From May 2012, six consecutive patients with advanced SFT received pazopanib, on a national name-based programme. In one case sunitinib was administered after pazopanib failure. Results In the …
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?
2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1). For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace chang…
Negative pressure cavitation-microwave assisted preparation of extract of Pyrola incarnata Fisch. rich in hyperin, 2'-O-galloylhyperin and chimaphili…
2013
Abstract A novel and effective extraction method, namely negative pressure cavitation-microwave assisted extraction technique (NMAE), was developed for the preparation of extracts of Pyrola incarnata Fisch., which are rich in the main constituents hyperin, 2′-O-galloylhyperin and chimaphilin. Single factor experiments and Box–Behnken design (BBD) were combined with a response surface methodology to examine factors affecting extraction. Maximum extraction yields of hyperin, 2′-O-galloylhyperin and chimaphilin (1.339 ± 0.029, 4.831 ± 0.117 and 0.329 ± 0.011 mg/g, respectively) were achieved under the following optimised conditions: 700 W microwave power, 50 °C extraction temperature, 30:1 mL/…
A snapshot of pneumonia research activity and collaboration patterns (2001–2015): a global bibliometric analysis
2019
Background This article describes a bibliometric review of the scientific production, geographical distribution, collaboration, impact, and subject area focus of pneumonia research indexed on the Web of Science over a 15-year period. Methods We searched the Web of Science database using the Medical Subject Heading (MeSH) of “Pneumonia” from January 1, 2001 to December 31, 2015. The only document types we studied were original articles and reviews, analyzing descriptive indicators by five-year periods and the scientific production by country, adjusting for population, economic, and research-related parameters. Results A total of 22,694 references were retrieved. The number of publications in…
Anomalies from the phenomenological and geometrical points of view
2008
Chiral anomalies are reviewed according to three different points of view: the usual approach together with some phenomenological implications, the algebraic approach, and, in the end and more detailed, the geometric approach. In particular, the topological approach of the Atiyah-Singer is extended in a way which allows the treatment of all chiral anomalies within the geometric (equivariant) point of view.
A multi-temporal study of chlorophyll-a concentration in the Albufera lagoon of Valencia, Spain, using Thematic Mapper data
1990
Abstract A multi-temporal study of chlorophyll-a concentration, has been made by means of Landsat-5 Thematic Mapper (TM) band 1 (0·45-0·52μm) in the Albufera of Valencia, a hypertrophic lagoon of shallow depth. The relationship between this parameter and satellite data was set up from in situ measurements and concurrent satellite data obtained in a campaign from 22 July 1985. This relation has been applied to images of different dates by using a simple procedure of correction, which is based on the use of selected surfaces whose ground reflectance is assumed to be constant with time. Good results were obtained and chlorophyll-a concentrations have been determined with an error of 20 per cen…
Towards the quantitative and physically-based interpretation of solar-induced vegetation fluorescence retrieved from global imaging
2021
Due to emerging high spectral resolution, remote sensing techniques and ongoing developments to retrieve the spectrally resolved vegetation fluorescence spectrum from several scales, the light reactions of photosynthesis are receiving a boost of attention for the monitoring of the Earth's carbon balance. Sensor-retrieved vegetation fluorescence (from leaf, tower, airborne or satellite scale) originating from the excited antenna chlorophyll a molecule has become a new quantitative biophysical vegetation parameter retrievable from space using global imaging techniques. However, to retrieve the actual quantum efficiencies, and hence a true photosynthetic status of the observed vegetation, all …
Multitemporal Monitoring of Plant Area Index in the Valencia Rice District with PocketLAI
2016
Leaf area index (LAI) is a key biophysical parameter used to determine foliage cover and crop growth in environmental studies in order to assess crop yield. Frequently, plant canopy analyzers (LAI-2000) and digital cameras for hemispherical photography (DHP) are used for indirect effective plant area index (PAI(eff)) estimates. Nevertheless, these instruments are expensive and have the disadvantages of low portability and maintenance. Recently, a smartphone app called PocketLAI was presented and tested for acquiring PAI(eff) measurements. It was used during an entire rice season for indirect PAI(eff) estimations and for deriving reference high-resolution PAI(eff) maps. Ground PAI(eff) value…
An automated on-line multidimensional HPLC system for protein and peptide mapping with integrated sample preparation.
2002
A comprehensive on-line two-dimensional 2D-HPLC system with integrated sample preparation was developed for the analysis of proteins and peptides with a molecular weight below 20 kDa. The system setup provided fast separations and high resolving power and is considered to be a complementary technique to 2D gel electrophoresis in proteomics. The on-line system reproducibly resolved approximately 1000 peaks within the total analysis time of 96 min and avoided sample losses by off-line sample handling. The low-molecular-weight target analytes were separated from the matrix using novel silica-based restricted access materials (RAM) with ion exchange functionalities. The size-selective sample fr…
Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation
2012
Gene expression profiles can be used to infer previously unknown transcriptional regulatory interaction among thousands of genes, via systems biology 'reverse engineering' approaches. We 'reverse engineered' an embryonic stem (ES)-specific transcriptional network from 171 gene expression profiles, measured in ES cells, to identify master regulators of gene expression ('hubs'). We discovered that E130012A19Rik (E13), highly expressed in mouse ES cells as compared with differentiated cells, was a central 'hub' of the network. We demonstrated that E13 is a protein-coding gene implicated in regulating the commitment towards the different neuronal subtypes and glia cells. The overexpression and …