Search results for "Mapping"

Mappings of finite distortion between metric measure spaces

2015

We establish the basic analytic properties of mappings of finite distortion between proper Ahlfors regular metric measure spaces that support a ( 1 , 1 ) (1,1) -Poincaré inequality. As applications, we prove that under certain integrability assumption for the distortion function, the branch set of a mapping of finite distortion between generalized n n -manifolds of type A A has zero Hausdorff n n -measure.

Phenotypic spectrum and genomics of undiagnosed arthrogryposis multiplex congenital

2022

BackgroundArthrogryposis multiplex congenita (AMC) is characterised by congenital joint contractures in two or more body areas. AMC exhibits wide phenotypic and genetic heterogeneity. Our goals were to improve the genetic diagnosis rates of AMC, to evaluate the added value of whole exome sequencing (WES) compared with targeted exome sequencing (TES) and to identify new genes in 315 unrelated undiagnosed AMC families.MethodsSeveral genomic approaches were used including genetic mapping of disease loci in multiplex or consanguineous families, TES then WES. Sanger sequencing was performed to identify or validate variants.ResultsWe achieved disease gene identification in 52.7% of AMC index pati…

2020

(1) Background: Assessments of intervertebral disc (IVD) changes, and IVD tissue adaptations due to physical activity, for example, remains challenging. Newer magnetic resonance imaging techniques can quantify detailed features of the IVD, where T2-mapping and T2-weighted (T2w) and Dixon imaging are potential candidates. Yet, their relative utility has not been examined. The performances of these techniques were investigated to characterize IVD differences in asymptomatic individuals with distinct physical activity histories. (2) Methods: In total, 101 participants (54 women) aged 25–35 years with distinct physical activity histories but without histories of spinal disease were included. T1…

A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.

2000

In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals…

Characterization of Intervertebral Disc Changes in Asymptomatic Individuals with Distinct Physical Activity Histories Using Three Different Quantitat…

2020

(1) Background: Assessments of intervertebral disc (IVD) changes, and IVD tissue adaptations due to physical activity, for example, remains challenging. Newer magnetic resonance imaging techniques can quantify detailed features of the IVD, where T2-mapping and T2-weighted (T2w) and Dixon imaging are potential candidates. Yet, their relative utility has not been examined. The performances of these techniques were investigated to characterize IVD differences in asymptomatic individuals with distinct physical activity histories. (2) Methods: In total, 101 participants (54 women) aged 25&ndash

Emotional Data in Music Performance : Two Audio Environments for the Emotional Imaging Composer

2013

Technologies capable of automatically sensing and recognizing emotion are becoming increasingly prevalent in performance and compositional practice. Though these technologies are complex and diverse, we present a typology that draws on similarities with computational systems for expressive music performance. This typology provides a framework to present results from the development of two audio environments for the Emotional Imaging Composer, a commercial product for realtime arousal/valence recognition that uses signals from the autonomic nervous system. In the first environment, a spectral delay processor for live vocal performance uses the performer's emotional state to interpolate betwe…

Numerical construction of the density-potential mapping

2018

We demonstrate how a recently developed method Nielsen et al. [Nielsen et al., EPL 101, 33001 (2013)] allows for a comprehensive investigation of time-dependent density functionals in general, and of the exact time-dependent exchange-correlation potential in particular, by presenting the first exact results for two- and three-dimensional multi-electron systems. This method is an explicit realization of the Runge–Gross correspondence, which maps time-dependent densities to their respective potentials, and allows for the exact construction of desired density functionals. We present in detail the numerical requirements that makes this method efficient, stable and precise even for large and rap…

The state of research on software engineering competencies: A systematic mapping study

2022

Considering the critical role of software in modern societies, we face an urgent need to educate more competent software professionals. Software engineering competencies (SEC) are considered the backbone of successfully developing software products. Consequently, SEC has become a hotspot for software engineering research and practice. Although scientific literature on SEC is not lacking, to our knowledge, a comprehensive overview of the current state of SEC research is missing. To that end, we conducted an extensive and systematic review of the SEC literature. We provide an overview of the current state of research on SEC, with a particular focus on common SEC research areas. In addition to…

“Dealing With Patients’ Mobility Issues: An Inter-Institutional Perspective To Analyze The Phenomenon And To Support Sustainable Policy Making In Sic…

2014

Nowadays many Italian policy makers, both at a national and regional level, are devoting a growing attention to the phenomenon of patients’ movements seeking public healthcare treatments out of the territorial jurisdiction. This paper presents the main features of a research project being carried out to analyze the mobility flows of Sicilian patients towards other Italian Regions in order to support the design of sustainable related policies. Such study adopts an inter-institutional perspective as the design of sustainable mobility-related policies requires a coordination effort of the Regional Healthcare Department, the Local Health Authorities and the Healthcare providers. The main outcom…

Early evolutionary colocalization of the nuclear ribosomal 5S and 45S gene families in seed plants: evidence from the living fossil gymnosperm Ginkgo…

2012

In seed plants, the colocalization of the 5S loci within the intergenic spacer (IGS) of the nuclear 45S tandem units is restricted to the phylogenetically derived Asteraceae family. However, fluorescent in situ hybridization (FISH) colocalization of both multigene families has also been observed in other unrelated seed plant lineages. Previous work has identified colocalization of 45S and 5S loci in Ginkgo biloba using FISH, but these observations have not been confirmed recently by sequencing a 1.8 kb IGS. In this work, we report the presence of the 45S–5S linkage in G. biloba, suggesting that in seed plants the molecular events leading to the restructuring of the ribosomal loci are much o…