Search results for "Marge"

A geological field trip to the Côte d'Ivoire-Ghana transform margin

1998

Abstract During the Equanaute survey (June 1992), fourteen submersible dives were performed between 4950 and 2250 m water depths across the southern slope of the Cote d'Ivoire-Ghana Marginal Ridge (CIGMR), in the eastern Equatorial Atlantic. The CIGMR, a high-standing topographic marginal ridge along the Cote d'Ivoire-Ghana transform margin, is believed to result from a complex structural evolution due to the specific wrench-related rifting between Western Equatorial Africa and Northeastern Brazil, in Early Cretaceous times. In this paper we report and discuss geological observations made during dives, and sample analyses to resolve the lithology, paleoenvironmental conditions, age and orig…

Papel prognóstico da margem de ressecção em cirurgia oncológica aberta de laringe: análise de sobrevida de uma coorte de 139 pacientes com carcinoma …

2019

Introduction: The treatment of laryngeal squamous cell carcinoma needs accurate risk stratification, in order to choose the most suitable therapy. The prognostic significance of resection margin is still highly debated, considering the contradictory results obtained in several studies regarding the survival rate of patients with a positive resection margin. Objective: To evaluate the prognostic role of resection margin in terms of survival and risk of recurrence of primary tumour through survival analysis. Methods: Between 2007 and 2014, 139 patients affected by laryngeal squamous cell carcinoma underwent partial or total laryngectomy and were followed for mean of 59.44 ± 28.65 months. Rese…

Margetuximab (M) combined with anti-PD-1 (retifanlimab) or anti-PD-1/LAG-3 (tebotelimab) +/- chemotherapy (CTX) in first-line therapy of advanced/met…

2021

TPS264 Background: Trastuzumab (T), a monoclonal antibody (mAb) targeting HER2, is standard of care 1st-line therapy for advanced HER2+ GEJ/GC patients. M, an investigational Fc-engineered anti-HER2 mAb, targets the same HER2 epitope but with higher affinity for both 158V (high binding) and 158F (low binding) alleles of activating Fc receptor CD16A. Data suggest margetuximab coordinately enhances both innate and adaptive immunity, including antigen-specific T-cell responses to HER2. PD-1 and LAG-3 are T-cell checkpoint molecules that suppress T-cell function. Retifanlimab (also known as MGA012 or INCMGA00012) is a humanized, hinge-stabilized, IgG4 Κ anti-PD-1 mAb blocking binding of PD-L1 …

The determinants of net interest income in the Mexican banking system: An integrated model

2009

This paper analyzes net interest income in the Mexican banking system over the period 1993-2005. Taking as reference the seminal work by Ho and Saunders (1981) and subsequent extensions by other authors, our study models the net interest margin simultaneously including operating costs and diversification and specialization as determinants of the margin. The results referring to the Mexican case show that its high margins can be explained mainly by average operating costs and by market power. Although non-interest income has increased in recent years, its economic impact is low. El trabajo analiza el margen de intermediación de la banca Mexicana en el periodo 1996-2005. Tomando como referenc…

Choix du système électoral et Convention européenne des droits de l'homme : quelques observations à la lumière d'une affaire concernant une loi élect…

2013

Within the space of less than two years the European Court of Human Rights and the Italian Constitutional Court have returned almost opposing judgments on the question of the observance of political rights by Italy’s 2005 electoral law. The ECHR found the applications made to it by groups of electors inadmissible given the manifestly ill-founded character of the grievances they were based on. The Constitutional Court, on the contrary, concluded that the law was unconstitutional. At first sight, the differing approaches by the two courts and the differing conclusions they reached may be viewed as an expression of the complementary nature of the European system of protection of human rights w…

Sobreros

1988

Les apports de la stratigraphie à l'évolution paléogéographique du Nord de l'Afrique au Jurassique : un bilan.

2007

46 pages; International audience

Lautsi contra Italia: sobre la libertad religiosa y los deberes de neutralidad e imparcialidad del Estado.

2011

RESUMENRecientemente, la Gran Sala del Tribunal Europeo de Derechos Humanos ha resuelto que la presencia del crucifijo en las aulas italianas no supone una vulneración del derecho de los padres a asegurar la educación de sus hijos de conformidad con sus propias creencias religiosas y de los deberes de neutralidad e imparcialidad estatal impuestos por el derecho de libertad religiosa. Con ello revocaba una decisión en sentido contrario de una Sala de la Sección Segunda del propio tribunal. En el trabajo se repasan críticamente los fundamentos de la decisión definitiva, basada principalmente en el reconocimiento de un amplio margen de discrecionalidad en la actuación de las autoridades nacion…

Afghanistan and the language of equality : a social contract in the making on a world-system fault

2013

The international intervention in Afghanistan started more than ten years ago. It built on new institutions according to the democratic model, complete with concepts generalized in the Western world since the 18th century, and among them the principle of equality. This model had founded the Amirs’ wished socio-political changes all along the 20th century, but ended in an on-going 30-year chaos with ever-renewed adversaries since the 1970’s. As operated in Afghanistan, tribalism and modernity – meant as an ideology, result in opposition prevaling as a social behaviour, which produces fragmentation or destruction and deals with equality demands through group honor. Consequently, traditionalis…

Margetuximab (M) combined with anti-PD-1 (MGA012) or anti-PD-1/LAG-3 (MGD013) +/- chemotherapy (CTX) in first-line therapy of advanced/metastatic HER…

2020

TPS468 Background: Trastuzumab (T), a monoclonal antibody (mAb) targeting HER2, is standard of care palliative 1st-line therapy for advanced HER2+ GEJ/GC patients (pts). M, an Fc-engineered anti-HER2 mAb, targets the same HER2 epitope but with higher affinity for both 158V (high binding) and 158F (low binding) alleles of activating Fc receptor CD16A. M coordinately enhanced both innate and adaptive immunity, including antigen-specific T-cell responses to HER2. PD-1 and LAG-3 are T-cell checkpoint molecules that suppress T-cell function. MGA012 (INCMGA00012) is a humanized, hinge-stabilized, IgG4 κ anti-PD-1 mAb blocking binding of PD-L1 or PD-L2 to PD-1. MGD013 is a humanized Fc-bearing bi…