Search results for "Marker"
showing 10 items of 3799 documents
Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis
2021
Background: Serum neurofilament light chain (sNfL) is a promising biomarker to complement the decision-making process in multiple sclerosis (MS) patients. However, although sNfL levels are able to detect disease activity and to predict future disability, the growing evidence has not yet been translated into practicable recommendations for an implementation into clinical routine. Methods: The observation of a patient with extensive inflammatory activity in magnetic resonance imaging (MRI) along with an extremely high sNfL level in the absence of any clinical symptoms prompted us to investigate common characteristics of our MS patients with the highest sNfL levels in a retrospective cohort st…
Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose
2018
This paper presents a novel diagnostic method using a library of molecular receptors to assess the composition of healthy and tumorous tissue samples. Molecular receptors were formed by self-organization of N-lipidated peptides attached in the regular fashion via aminophenylamino-1,3,5-triazine linkers to the surface of a cellulose plate. The library was cloned into multiple, identical copies. A new clone was used in each test. The binding process was monitored by staining the discs with Brilliant Black and quantitative color measure- ment was performed in 256-grade grayscale. Substantial differences in the composition of healthy and tumor samples were observed in most cases. The sharp diff…
Development of a nomogram for the estimation of long-term adherence to clozapine therapy using neutrophil fluorescence
2018
Aims: Previously, we have reported an association between clozapine use and elevated FL3 neutrophil fluorescence, a flow-cytometric parameter for cell viability. Here, we developed and evaluated a pharmacokinetic-pharmacodynamic model relating FL3-fluorescence to clozapine exposure and derived a nomogram for estimation of long-term adherence. Methods: Data from 27 patients initiating clozapine were analysed using nonlinear mixed effects modelling. A previously described pharmacokinetic model for clozapine was coupled to a FL3 fluorescence model. For this, an effect compartment with clozapine concentrations as input and a first order decay rate as output was linked with an Emax model to FL3-…
The genetics of phenotypic plasticity in livestock in the era of climate change: a review
2020
Climate change has the potential to adversely affect the health of livestock, with consequences to animal welfare, greenhouse gas emissions, productivity, human health and livelihoods. Phenotypic plasticity is the ability of a genotype to produce different phenotypes, depending on environmental, biotic or abiotic conditions; it is a factor influencing and modifying the genes of animal and plant organisms, to adaptation to climate change. Among the various climate variables, heat stress has been reported to be the most detrimental factor to the economy of the livestock industry. There are a number of candidate genes that are associated with adaptation of ruminants, monogastric and poultry to…
The grammaticalization and pragmaticalization of cleft constructions in Present-Day English
2012
The present paper examines the development of the variation between a marked and an unmarked infinitival complement clause in three types of cleft constructions in 20th century English. Data from corpora of written and spoken British (BrE) and American English (AmE) evidence a significantly divergent development of these clefts types in speaking when compared to writing. The written corpora show a steady increase in the frequency of clefts, and a decrease of the to-infinitive paired with an increase of the bare infinitive, thus a reversal of preferences in both varieties in all three types of clefts. This erosion of to as an (optional) grammatical marker leads to a higher degree of syntacti…
Genetics on Invasive Species
2002
Genetic markers are especially appropriate to reveal historical processes, as for example regarding biological invasions. Phylogenetic and population genetic methods enable to identify the taxa involved in an invasion (native and non-native species) and often lead to the perception of multiple or cryptic invasions. Phylogeographic and multi-locus approaches have been developed to assign individual invaders to potential source populations. The results may have implications for management measures. However, little is known about the genetic architecture of newly colonised populations. We introduce here genetic models for colonisations in linear habitats like rivers or coastlines. The expectat…
Mecanismos de atenuación entre el decir y lo dicho: procesos de enunciación a través de la partícula discursiva digamos
2018
Este trabajo presenta los resultados obtenidos en el análisis de la partícula discursiva digamos en corpus coloquiales (Val.Es.Co. 2002 y 2.0.), aplicando el sistema de unidades, niveles y posiciones Val.Es.Co. (Briz y grupo Val.Es.Co. 2003, 2014) y la ficha Es. Por. Atenuación (Albelda et alii 2014). El resultado integra dos perspectivas de análisis para determinar si factores como la unidad ocupada o posición discursiva condicionan su polifuncionalidad. This study presents the results obtained from the analysis of the Spanish discourse particle digamos in colloquial corpus. The Val.Es.Co. proposal (Briz et alii 2003, 2014) and the Es.Var.Atenuación analysis sheet (Albelda et alii 2014) ar…
On the model dependence of fiducial cross-section measurements
2019
Fiducial production cross-section measurements of Standard Model processes, in principle, provide constraints on new physics scenarios via a comparison of the predicted Standard Model cross-section and the observed cross-section. This approach received significant attention in recent years, both from direct constraints on specific models and the interpretation of measurements in the view of effective field theories. A generic problem in the reinterpretation of Standard Model measurements is the corrections application of to data to account for detector effects. These corrections inherently assume the Standard Model to be valid, thus implying a model bias of the final result. In this work, …
Biomarkers of Oxidative Stress in Acute and Chronic Diseases
2022
Molecular biomarkers consent to apply individual decisions in the complex management of both acute or chronic diseases, and their identification constitutes a fundamental phase for achieving the important object to develop personalized therapies [...]
Release of Hypoacetylated and Trimethylated Histone H4 Is an Epigenetic Marker of Early Apoptosis
2006
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