Search results for "Marr"
showing 10 items of 776 documents
T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells
1980
Fully allogeneic, chimeric mice were established by adult thymectomy of (A × B) F1animals, grafting parental A-type thymus under the kidney capsula, followed by lethal (900 rd) irradiation and reconstitution with B parental-type bone marrow cells treated with xenogeneic anti-T cell antiserum plus complement. Following in vivo sensitization with inactivated Sendai virus (SV) suspensions, no virus-specific T cells could be detected within the spleen cells of the mice. Upon stimulation with third-party allogeneic cells in a primary mixed lymphocyte culture, spleen cells of all animals generated alloreactive cytotoxic T lymphocytes (CTL). More interestingly, upon secondary in vitro stimulation …
Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs
2015
International audience; Fanconi anemia is a DNA repair-deficiency syndrome mainly characterized by cancer predisposition and bone marrow failure. Trying to restore the hematopoietic function in these patients, lentiviral vector-mediated gene therapy trials have recently been proposed. However, because no insertional oncogenesis studies have been conducted so far in DNA repair-deficiency syndromes such as Fanconi anemia, we have carried out a genome-wide screening of lentiviral insertion sites after the gene correction of Fanca-/- hematopoietic stem cells (HSCs), using LAM-PCR and 454-pyrosequencing. Our studies first demonstrated that transduction of Fanca-/- HSCs with a lentiviral vector d…
How I diagnose and treat splenic lymphomas.
2011
Abstract The incidental finding of an isolated splenomegaly during clinical assessment of patients evaluated for unrelated causes has become increasingly frequent because of the widespread use of imaging. Therefore, the challenging approach to the differential diagnosis of spleen disorders has emerged as a rather common issue of clinical practice. A true diagnostic dilemma hides in distinguishing pathologic conditions primarily involving the spleen from those in which splenomegaly presents as an epiphenomenon of hepatic or systemic diseases. Among the causes of isolated splenomegaly, lymphoid malignancies account for a relevant, yet probably underestimated, number of cases. Splenic lymphoma…
Comunicació 2.0 i gènere
2009
Internet ha capgirat les formes de comunicació i d’intercanvi d’informació entre les persones: les receptores en el procés comunicatiu són ara també emissores. La conjunció d’aquesta particularitat amb l’aparició i ús d’algunes eines de comunicació (fàcils d’usar i bàsicament gratuïtes) permet parlar d’un fenomen social de gran abast: la comunicació 2.0. Aquest article analitza algunes de les característiques d’aquesta classe d’interacció i centra l’interés de forma particular en certes iniciatives que tenen com a epicentre les qüestions de gènere. La comunicació 2.0 permet la participació activa i directa en el procés, obert i col·laboratiu, de construcció de la identitat pròpia. Així mate…
Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis
2006
Familial haemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder characterised by constitutive defects in cellular cytotoxicity resulting in fever, hepatosplenomegaly and cytopenia, and the outcome is fatal unless treated by chemoimmunotherapy followed by haematopoietic stem‐cell transplantation. Since 1999, mutations in the perforin gene giving rise to this disease have been identified; however, these account only for 40% of cases. Lack of a genetic marker hampers the diagnosis, suitability for transplantation, selection of familial donors, identification of carriers, genetic counselling and prenatal diagnosis. Mutations in the Munc13–4 gene have recently been des…
"Od Wmci Pani już bardzo dawno miałem wiadomość, proszę, abyś mi doniosła o zdrowiu swoim i obrotach...". Wojenne doświadczenia Elżbiety z Branickiej…
2018
Elżbieta z domu Branicka była od 1732 roku trzecią żoną Jana Tarły, wojewody lubelskiego, a od 1736 roku wojewody sandomierskiego. Korespondencja pomiędzy małżonkami wskazuje na dobre relacje, oparte o wzajemna troskę i zaufania. No to ostatnie Elżbieta w pełni zasługiwała za swoja postawę w latach 1733 - 1736 przetrwać trudne czasy wojny. W rzeczywistości stawiała czoła realnym, być może wyolbrzymionym zagrożeniom. Uwypukliło to takie cechy jej charakteru, jak zdecydowanie, zaradność, i odporność na sytuacje kryzysowe. Elżbieta z Branickich Tarłowa potrafiła dbać o siebie, męża i majątek rodzinny.
EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance
2016
Abstract Bone marrow (BM) homing and lodgment of long-term repopulating hematopoietic stem cells (LT-HSCs) are active and essential first steps during embryonic development and in clinical stem cell transplantation. Rare, BM LT-HSCs endowed with the highest self-renewal and durable repopulation potential, functionally express the anticoagulant endothelial protein C receptor (EPCR) and PAR1. In addition to coagulation and inflammation, EPCR-PAR1 signaling independently controls a BM LT-HSC retention-release switch via regulation of nitric oxide (NO) production within LT-HSCs. EPCR+ LT-HSCs are maintained in thrombomodulin+ (TM) periarterial BM microenvironments via production of activated pr…
From Regenerative Medicine to Endothelial Progenitor Cells as Potential Candidates
2017
A promising branch of translational medicine is Regenerative Medicine (RegMed). RegMed aims to improve health and quality of life by restoring, maintaining or enhancing tissues and functions of organs. In order to achieve this, RegMed utilizes several approaches. Among these, cell-based therapy represents the central focus of RegMed. Several cellular types have been considered for the investigation and application of regenerative cell therapy in disease organs. and bone marrow (BM)-derived endothelial progenitor cells (BM EPCs) are emerging as potential candidates. Here, particular emphasis is given to the description of their biological features, for understanding their relevance and poten…
Epitalamios e himeneos. Iconografía y literatura nupcial en las cortes del Barroco.
2010
En este estudio se aborda, bajo una visión general, los textos y las imágenes presentes en algunos epitalamios e himeneos: composiciones poéticas de los siglos XVII y XVIII, realizadas en las cortes europeas con motivo de los matrimonios concertados entre sus miembros. Sus imágenes emblemáticas y simbólicas, son de gran interés para la historia del arte, pues se inspiran en las composiciones de los libros de emblemas del periodo y desarrollan temas habituales en la literatura matrimonial. No obstante, lo más significativo son los mensajes políticos que difunden, fundamentalmente los beneficios políticos de las uniones dinásticas. This study deals, from a general point of view, with the text…
En torno al artículo 76.2 del código civil : Comentario a la sap barcelona núm. 21/2020, de 15 de enero
2021
Nullity of marriage due to the spouse´s mistake regarding a significant personal quality of her spouse (art. 73.4º CC) (transvestism). The validation itself requires a conjugal life ininterrupted for a year after the error´s disappearance