Search results for "Marr"

Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin

2000

Abstract The low frequency of transplantable hematopoietic stem cells in adult human bone marrow (BM) and other differences from cord blood stem cells have impeded studies to optimize the retroviral transduction of stem cells from adult sources. To address this problem, first a cytokine combination was defined that would both maximize the kinetics of adult BM CD34+CD38− cell mitogenesis and minimize the period of prestimulation required for the transduction of these cells by a MSCV-GFP/neor virus in tissue culture dishes in the absence of fibronectin. Three days of stimulation with flt3-ligand, Steel factor, interleukin (IL)-3, and hyper-IL-6 proved both necessary and sufficient to obtain 8…

European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from pref…

2012

Any study of myeloproliferative neoplasms (MPNs) that lacks adequate clinical input is doomed to cause diagnostic uncertainty and increased controversy. In the paper by Buhr et al. published in Haematologica,[1][1] the authors studied 102 cases of essential thrombocythemia (ET) and early primary

Prefazione

2010

An introduction to the book of Francesca Freeman, dealing with the history and anthropology of a matriarchal society

Editorial - Connecting the Dots: The Promises of Wharton's Jelly Mesenchymal Stem Cells for Tissue Repair and Regeneration

2011

Mesenchymal stem cells (MSC) constitute a variety of cellular populations which were described first about 35 years ago in the bone marrow (BM) stroma [1]. These years have foreseen an exponential increase of reports pointing out features, stemness, markers, tissue sources and clinical applications of these cells. Cells with MSC features can be isolated from virtually every adult organ in the body, as well from a group of fetus-associated sources (cells derived from the latter tissues are collectively known as perinatal stem cells) [2]. In recent years, the umbilical cord arose as a promising source of mesenchymal stem cells, which can be isolated in relatively high numbers (compared to BM)…

HSP27: A Therapeutic Target in Myelofibrosis

2016

Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive bone marrow fibrosis resulting into bone marrow failure. JAK2 kinase inhibitors have been successfully used for a few years in MPN and more particularly for MF treatment. Despite their beneficial effects on spleen size and symptoms, JAK2 inhibitors induce low molecular and survival responses underscoring the urgent need for other therapeutic approaches. Recently, heat shock protein 90 (HSP90) - known to stabilize JAK2 - has been reported as a promising therapeutic target in MPN. However HSP90 inhibitors show toxicity and induce the e…

Electrical conductivity as a state indicator for the start-up period of anaerobic fixed-bed reactors.

2016

The aim of this work was to analyse the applicability of electrical conductivity sensors for on-line monitoring the start-up period of an anaerobic fixed-bed reactor. The evolution of bicarbonate concentration and methane production rate was analysed. Strong linear relationships between electrical conductivity and both bicarbonate concentration and methane production rate were observed. On-line estimations of the studied parameters were carried out in a new start-up period by applying simple linear regression models, which resulted in a good concordance between both observed and predicted values. Electrical conductivity sensors were therefore identified as an interesting method for monitori…

Arrangements de cercles sur une sphère: Algorithmes et Applications aux modèles moléculaires representés par une union de boules

2008

Since the early work of Richard et al., geometric constructions havebeen paramount for the description of macromolecules and macro-molecularassemblies. In particular, Voronoï and related constructions have beenused to describe the packing properties of atoms, to compute molecularsurfaces, to find cavities. This thesis falls in this realm, andafter a brief introduction to protein structure, makes fourcontributions.First, using the sweep line paradigm of Bentley and Ottmann, wepresent the first effective algorithm able to construct the exactarrangement of circles on a sphere. Moreover, assuming the circlesstem from the intersection between spheres, we present a strategy to reportthe covering …

Etude de la réponse aux stress environmentaux chez deux lactobacilles: identification de régulateurs impliqués dans le stress oxidatif chez Lactobaci…

2005

Femmes indigènes et colons grecs : quelques observations

2010

Colloque organisé par la Maison René-Ginouvès, Nanterre, 10-12 juin 2009

L'homosexualité et la constitution de la famille : situations française et européenne

2016

The 2013-404 law of 17 May 2013 which opened up the possibility for people of the same gender to get married shows a turning point for the family rights in France. This law, sometimes described as a real tsunami, is the outcome of taking into account the homosexuals' claim for starting a family. Before 2013 the French right did not allow a homosexual couple to be a homoparental family. It did not authorize people of the same gender to get married. Moreover Assisted Reproduction is only reserved to heterosexual couples and Gestation for Others is strictly forbidden in France. This seemingly constrained consensus on the non-legal recognition of the homosexual family is reinforced by the Europ…