Search results for "Marr"

The Pro-Inflammatory IL23/IL23R/IL17 Axis Is Active in IL23R-Expressing Circulating CLL Cells in Patients with Poor Prognosis

2012

Abstract Abstract 3889 Inflammatory cytokines play a biological role in the pathogenesis of Chronic lymphocytic leukemia (CLL). IL23 is a pro-inflammatory cytokine involved in T-cell responses and in tissue remodeling. It has been shown that the IL23 receptor (IL23R) is up-regulated in primary acute lymphoblastic leukemia (ALL) cells, and that IL23 inhibits ALL cell growth. Nevertheless, the anti-tumor function of IL23 still remains controversial. The role of the IL23R/IL23 axis in CLL has not been investigated so far. Herein we evaluated the expression pattern of IL23R/IL23 axis and its correlation with progression free survival (PFS) in CLL patients. A total of 233 newly diagnosed Binet s…

New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

2018

Abstract The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II–III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were …

Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice

2019

Profilin 1 (Pfn1), a regulator of actin polymerization, controls cell movement in a context-dependent manner. Pfn1 supports the locomotion of most adherent cells by assisting actin-filament elongation, as has been shown in skeletal progenitor cells in our previous study. However, because Pfn1 has also been known to inhibit migration of certain cells, including T cells, by suppressing branched-end elongation of actin filaments, we hypothesized that its roles in osteoclasts may be different from that of osteoblasts. By investigating the osteoclasts in culture, we first verified that Pfn1-knockdown (KD) enhances bone resorption in preosteoclastic RAW264.7 cells, despite having a comparable num…

Management of Osteoporosis in Postmenopausal Women

2019

Osteoporosis is a noncommunicable disease with increasing incidence at a global level. The burden of the disease particularly concerns women. A drastic and rapid decline in the circulating levels of estrogens, a key regulator of bone metabolism, is responsible for the increase in bone loss after menopause. Cells with a role in bone metabolism, osteoblasts, osteoclasts and osteocytes, have estrogen receptors. The fall in estrogens increases the differentiation of osteoclasts from progenitors in the bone marrow. A significant expansion in the resorption process follows.

Tiilikainen, Marja, Al-Sharmani, Mulki and Mustasaari, Sanna (eds.) (2020) Wellbeing of Transnational Muslim Families. Marriage, Law and Gender. Lond…

2020

Book review of the book: Tiilikainen, Marja, Al-Sharmani, Mulki & Mustasaari, Sanna (eds.) (2020) Wellbeing of Transnational Muslim Families. Marriage, Law and Gender, London & New York: Routledge. 188 pp.

Japanese anime and women's gender-role changing

2015

Feminism is a fast growing phenomenon in recent years. This paper started with the historical conflict of marriage and feminism, then researched the connection between anime and gender-role. Since Japanese anime was imported to China in 1980s, it has influenced the generation born in 1980s and 1990s in many aspects of their growth. These well-educated people perceived the Japanese culture and values through anime. This study connected gender stereotypes and marriage, and how Chinese well-educated anime fans interpret the gender-role portrayals from anime. Eight well-educated young people born in 1980s and 1990s participated in this study through semi-structured online interviews. This study…

Erityinen ystävyys : miehen ja naisen välinen rakkaus uuden ajan alun Suomessa (n. 1650-1700)

2015

La experiencia imaginaria de Marruecos en la narrativa española contemporánea

2004

La tesis intenta investigar los auténticos motivos del incremento de las publicaciones narrativas sobre Marruecos, durante los últimos años. En lineas generales, pretende analizar la visión que los escritores españoles contemporáneos ofrecen del país vecino en sus novelas. Para ello, se hace un riguroso estudio de los temas que estas obras plantean y luego clarificarlos en bloques diferenciados: La visión del "otro", la sociedad, la religión, la mitología y creencias populares, la inmigración vista desde la otra orilla. A partir de los resultados de este análisis se podrá ver, con claridad, como va evolucionando la imagen de Marruecos, y si hubo una madurez en la forma de tratar los temas d…

Narratives by women managers about spousal support for their careers

2014

In this article we present a qualitative study of spousal support for the careers of women managers. The research material consists of the narratives of 25 women managers in Finland. The study has two main implications. Firstly, unlike previous studies, we use a narrative approach to demonstrate that a woman manager's career and spousal support are experienced as ambiguous and evolving over the career. The support was constructed by the women managers as flourishing, irrelevant, deficient or inconsistent. Secondly, to increase our knowledge about gender relations, we combine discussion of the topic with gender order analysis and suggest that gender order is critical for an understanding of …

Novel Translational Read-through–Inducing Drugs as a Therapeutic Option for Shwachman-Diamond Syndrome

2022

Shwachman-Diamond syndrome (SDS) is one of the most commonly inherited bone marrow failure syndromes (IBMFS). In SDS, bone marrow is hypocellular, with marked neutropenia. Moreover, SDS patients have a high risk of developing myelodysplastic syndrome (MDS), which in turn increases the risk of acute myeloid leukemia (AML) from an early age. Most SDS patients are heterozygous for the c.183-184TA>CT (K62X) SBDS nonsense mutation. Fortunately, a plethora of translational read-through inducing drugs (TRIDs) have been developed and tested for several rare inherited diseases due to nonsense mutations so far. The authors previously demonstrated that ataluren (PTC124) can restore full-length SBDS…