Search results for "Matrix"

Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein.

2009

Contains fulltext : 80984.pdf (Publisher’s version ) (Closed access) Usher syndrome (USH) and Leber congenital amaurosis (LCA) are autosomal recessive disorders resulting in syndromic and non-syndromic forms of blindness. In order to gain insight into the pathogenic mechanisms underlying retinal degeneration, we searched for interacting proteins of USH2A isoform B (USH2A(isoB)) and the LCA5-encoded protein lebercilin. We identified a novel isoform of the centrosomal ninein-like protein, hereby named Nlp isoform B (Nlp(isoB)), as a common interactor. Although we identified the capacity of this protein to bind calcium with one of its three EF-hand domains, the interacton with USH2A(isoB) did …

Allelic age of the USH2A c.2299delG mutation

2010

24 p., figuras y bibliografía

A bio-imitating approach to fabricate an artificial matrix for cartilage tissue engineering using magnesium-polyphosphate and hyaluronic acid

2016

Here we describe an artificial cartilage-like material based on a hyaluronic acid-Mg/Ca-polyphosphate paste (HA-aMg/Ca-polyP-p) that is fabricated from a water-soluble Na-salt of energy-rich inorganic polyphosphate (polyP) and soluble hyaluronic acid in the presence of water-insoluble CaCO3. The resulting material, after conversion of Na-polyP into the less soluble Mg/Ca-salt consisting of amorphous Mg/Ca-polyP microparticles, was found to mimic the physiological cartilage tissue and to bind Ca2+ ions present in the synovial fluid. After the Mg2+/Ca2+ exchange and water extrusion, the polyP becomes more stable, but is still susceptible to hydrolytic cleavage by the alkaline phosphatase (ALP…

UV laser induced photolysis of glycolic acid isolated in argon matrices

2021

The photochemistry of matrix-isolated glycolic acid, induced by UV light, was studied by FTIR spectroscopy and B3LYPD3/6-311++G(3df,3pd) calculations. Several decomposition pathways were found to take place upon 212 nm and 226 nm wavelengths irradiation. A number of complexes formed between photoproducts were identified, among them those of formaldehyde with water, carbon monoxide and carbon dioxide as well as the H2O-CO complexes. The structure and spectroscopic assignment of the photoproducts were made comparing the experimental results with the theoretical predictions and available literature data. The observed formation of different complexes indicates various pathways for their formati…

2020

Recommender systems are information software that retrieves relevant items for users from massive sources of data. The variational autoencoder (VAE) has proven to be a promising approach for recommendation systems, as it can explore high-level user-item relations and extract contingencies from the input effectively. However, the previous variants of VAE have so far seen limited application to domain-specific recommendations that require additional side information. Hence, The Ensemble Variational Autoencoder framework for recommendations (EnsVAE) is proposed. This architecture specifies a procedure to transform sub-recommenders’ predicted utility matrix into interest probabilities that allo…

2021

This paper proposes a new method for blind mesh visual quality assessment (MVQA) based on a graph convolutional network. For that, we address the node classification problem to predict the perceived visual quality. First, two matrices representing the 3D mesh are considered: a graph adjacency matrix and a feature matrix. Both matrices are used as input to a shallow graph convolutional network. The network consists of two convolutional layers followed by a max-pooling layer to provide the final feature representation. With this structure, the Softmax classifier predicts the quality score category without the reference mesh’s availability. Experiments are conducted on four publicly available …

In vivo comparative study of the effects of using the enamel matrix derivative and/or photobiomodulation on the repair of bone defects

2022

Made available in DSpace on 2022-05-01T13:57:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Background: The repair of bone defects has been the subject of many studies that have shown inconclusive results as to what is the best bone substitute. Material and Methods: Bone defects (0 2 mm) were induced on the tibia of seventy-two rats, which were distributed into the following four groups/treatments (n=18 each): Control: no treatment; EMD: enamel matrix derived protein; PBM: photobiomodulation therapy (660 nm, 0,035 W, 60 s); EMD + PBM: EMD and immediate treatment with PBM (660 nm, 0,035 W, 60 s). Six animals from each group were euthanized after 10, 30 and 60 days. Histologi…

The formation and mineralization of mollusk shell.

2011

27 pages; International audience; In the last years, the field of mollusk biomineralization has known a tremendous mutation. The most recent advances deal with the nanostructure of shell biominerals, and with the identification of several shell matrix proteins: on one hand, the complex hierarchical organization of shell biominerals has been deciphered in few models, like nacre. On the other hand, although proteins represent a minor shell component, they are the major macromolecules that control biocrystal synthesis. Until recently, the paradigm was to consider that this control occurs by two antagonist mechanisms: crystal nucleation and growth inhibition. Emerging models try to translate a …

Extending the spectral decomposition of Granger causality to include instantaneous influences: application to the control mechanisms of heart rate va…

2021

Assessing Granger causality (GC) intended as the influence, in terms of reduction of variance of surprise, that a driver variable exerts on a given target, requires a suitable treatment of ‘instantaneous’ effects, i.e. influences due to interactions whose time scale is much faster than the time resolution of the measurements, due to unobserved confounders or insufficient sampling rate that cannot be increased because the mechanism of generation of the variable is inherently slow (e.g. the heartbeat). We exploit a recently proposed framework for the estimation of causal influences in the spectral domain and include instantaneous interactions in the modelling, thus obtaining (i) a novel index…

Circular law for sparse random regular digraphs

2020

Fix a constant $C\geq 1$ and let $d=d(n)$ satisfy $d\leq \ln^{C} n$ for every large integer $n$. Denote by $A_n$ the adjacency matrix of a uniform random directed $d$-regular graph on $n$ vertices. We show that, as long as $d\to\infty$ with $n$, the empirical spectral distribution of appropriately rescaled matrix $A_n$ converges weakly in probability to the circular law. This result, together with an earlier work of Cook, completely settles the problem of weak convergence of the empirical distribution in directed $d$-regular setting with the degree tending to infinity. As a crucial element of our proof, we develop a technique of bounding intermediate singular values of $A_n$ based on studyi…