Search results for "Matrix"
showing 10 items of 3205 documents
Development of accurate mass spectrometric routine and reference methods for the determination of trace amounts of iridium and rhodium in photographi…
1999
For the determination of trace amounts of iridium and rhodium in photographic emulsions different sample treatment procedures were coupled with inductively coupled plasma mass spectrometry (ICP-MS) and, for iridium, also with negative thermal ionisation isotope dilution mass spectrometry (NTI-IDMS) and ICP-IDMS. IDMS determinations of iridium were carried out using an enriched 191Ir spike solution. Elimination of the silver matrix was established for both mass spectrometric methods, which prevents corresponding memory effects in the ICP-MS system and is essential for the formation of IrO2 - thermal ions, respectively. For NTI-MS measurements, the gelatine matrix of the emulsion must also be…
The Role of Covariance Matrix Forecasting Method in the Performance of Minimum-Variance Portfolios
2014
Providing a more accurate covariance matrix forecast can substantially improve the performance of optimized portfolios. Using out-of-sample tests, in this paper, we evaluate alternative covariance matrix forecasting methods by looking at (1) their forecast accuracy, (2) their ability to track the volatility of the minimum-variance portfolio, and (3) their ability to keep the volatility of the minimum-variance portfolio at a target level. We find large differences between the methods. Our results suggest that shrinkage of the sample covariance matrix improves neither the forecast accuracy nor the performance of minimum-variance portfolios. In contrast, switching from the sample covariance ma…
Null Space Based Image Recognition Using Incremental Eigendecomposition
2011
An incremental approach to the discriminative common vector (DCV) method for image recognition is considered. Discriminative projections are tackled in the particular context in which new training data becomes available and learned subspaces may need continuous updating. Starting from incremental eigendecomposition of scatter matrices, an efficient updating rule based on projections and orthogonalization is given. The corresponding algorithm has been empirically assessed and compared to its batch counterpart. The same good properties and performance results of the original method are kept but with a dramatic decrease in the computation needed.
Cross-talk between Different Enhancer Elements during Mitogenic Induction of the Human Stromelysin-1 Gene
1996
Platelet-derived growth factor (PDGF) induces the expression of human stromelysin-1, a matrix metalloproteinase involved in tumor invasion and metastasis. Here it is shown that stromelysin-1 gene induction by PDGF depends on Ras and involves three previously identified promoter elements (the stromelysin-1 PDGF-responsive element (SPRE) site, the two head-to-head polyomavirus enhancer A-binding protein-3 (PEA3) sites, and the activator protein-1 (AP-1) binding site). During mitogenic induction, these responsive elements appear to be organized in two independent transcriptional units, SPRE-AP-1 and PEA3-AP-1, which result from specific element cross-talking. Interestingly, expression of a dom…
Impairing Otp homeodomain function in oral ectoderm cells affects skeletogenesis in sea urchin embryos
2003
AbstractIn the sea urchin embryo skeletogenesis is the result of a complex series of molecular and cellular events that coordinate the morphogenetic process. Past and recent evidence strongly indicate that skeletal initiation and growth are strictly dependent on signals emanating from the oral ectodermal wall. As previously suggested, Orthopedia (Otp), a homeodomain-containing transcription factor specifically expressed in a small subset of oral ectoderm cells, might be implicated in this signalling pathway. In this study, we utilize three different strategies to address the issue of whether Otp is an upstream regulator of sketelogenesis. We describe the effects of microinjection of Otp mor…
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.
2010
We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mouse liver for at least 6 months following a single administration. Subsequently, we observed that transgene expression is sustained for the lifetime of the animal. The level of expression, however, does drop appreciably over time. We hypothesised that by eliminating the bacterial components in our vectors, we could improve their performance since bacterial sequences have been shown to be responsible for the immunotoxicity of the vector and the silencing of its expression when applied i…
Model for T2K indication with maximalθ23and trimaximalθ12
2011
Recently T2K experiment gives hint in favor of large reactor angle ${\ensuremath{\theta}}_{13}$. Most of the models, with tribimaximal mixing at the leading order, can not reproduce such a large mixing angle since they predict typically corrections for the reactor angle of the order ${\ensuremath{\theta}}_{13}\ensuremath{\sim}{\ensuremath{\lambda}}_{C}^{2}$, where ${\ensuremath{\lambda}}_{C}\ensuremath{\sim}0.2$. In this paper, we discuss the possibility to achieve large ${\ensuremath{\theta}}_{13}$ within the T2K region with maximal atmospheric mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{23}=1/2$, and trimaximal solar mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{12}=1/3$, through th…
Fast Poisson solvers for graphics processing units
2013
Two block cyclic reduction linear system solvers are considered and implemented using the OpenCL framework. The topics of interest include a simplified scalar cyclic reduction tridiagonal system solver and the impact of increasing the radix-number of the algorithm. Both implementations are tested for the Poisson problem in two and three dimensions, using a Nvidia GTX 580 series GPU and double precision floating-point arithmetic. The numerical results indicate up to 6-fold speed increase in the case of the two-dimensional problems and up to 3- fold speed increase in the case of the three-dimensional problems when compared to equivalent CPU implementations run on a Intel Core i7 quad-core CPU…
Multivariate optimization of the hollow fibre liquid phase microextraction of muscimol in human urine samples.
2016
Abstract A liquid phase microextraction based on hollow fibre followed by liquid chromatographic determination was developed for the extraction and quantitation of the hallucinogenic muscimol from urine samples. Method applicability on polar hallucinogens was also tested on two alkaloids, a psychedelic hallucinogen, tryptamine and a polar amino acid, tryptophan which exists in its charged state in the entire pH range. A multivariate design of experiments was used in which a half fractional factorial approach was applied to screen six factors (donor phase pH, acceptor phase HCl concentration, carrier composition, stirring rate, extraction time and salt content) for their extent of vitality i…
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
2011
BackgroundPeriostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data s…