Search results for "Matrix"
showing 10 items of 3205 documents
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
2003
Dysregulation of extracellular matrix turnover is an important feature of many inflammatory processes. Rat renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin-1 beta. We demonstrate that NO does strongly destabilize MMP-9 mRNA, since different luciferase reporter gene constructs containing the MMP-9 3' untranslated region (UTR) displayed significant reduced luciferase activity in response to the presence of NO. Moreover, by use of an in vitro degradation assay we found that the cytoplasmic fractions of NO-treated cells contained a higher capacity to degrade MMP-9 transcripts than those obtained from contro…
Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila
2005
Myotonic dystrophy type 1 is an autosomal dominant disorder associated with the expansion of a CTG repeat in the 3 0 untranslated region (UTR) of the DMPK gene. Recent data suggest that pathogenesis is predominantly mediated by a gain of function of the mutant transcript. In patients, these expanded CUG repeat-containing transcripts are sequestered into ribonuclear foci that also contain the muscleblind-like proteins. To provide further insights into muscleblind function and the pathogenesis of myotonic dystrophy, we generated Drosophila incorporating CTG repeats in the 3 0 -UTR of a reporter gene. As in patients, expanded CUG repeats form discrete ribonuclear foci in Drosophila muscle cell…
Peptide classification using optimal and information theoretic syntactic modeling
2010
Accepted version of an article published in the journal: Pattern Recognition. Published version available on Sciverse: http://dx.doi.org/10.1016/j.patcog.2010.05.022 We consider the problem of classifying peptides using the information residing in their syntactic representations. This problem, which has been studied for more than a decade, has typically been investigated using distance-based metrics that involve the edit operations required in the peptide comparisons. In this paper, we shall demonstrate that the Optimal and Information Theoretic (OIT) model of Oommen and Kashyap [22] applicable for syntactic pattern recognition can be used to tackle peptide classification problem. We advoca…
BIBO Stability Analysis for Delay Switched Systems with Nonlinear Perturbation
2013
Published version of a paper from the journal:Abstract and Applied Analysis. Also available from Hindawi:http://dx.doi.org/10.1155/2013/738653 The problem of bounded-input bounded-output ( BIBO) stability is investigated for a class of delay switched systems with mixed time-varying discrete and constant neutral delays and nonlinear perturbation. Based on the Lyapunov-Krasovskii functional theory, new BIBO stabilization criteria are established in terms of delay-dependent linear matrix inequalities. The numerical simulation is carried out to demonstrate the effectiveness of the results obtained in the paper.
A linear matrix inequality approach to robust fault detection filter design of linear systems with mixed time-varying delays and nonlinear perturbati…
2010
Accepted version of an article in the journal: Journal of the Franklin Institute-Engineering and Applied Mathematics. The definitive version can be found on Sciverse: http://dx.doi.org/10.1016/j.jfranklin.2010.03.004 In this paper, the problem of robust fault detection filter (RFDF) design for a class of linear systems with some nonlinear perturbations and mixed neutral and discrete time-varying delays is investigated. By using a descriptor technique, Lyapunov-Krasovskii functional and a suitable change of variables, new required sufficient conditions are established in terms of delay-dependent linear matrix inequalities (LMIs) to synthesize the residual generation scheme. Based on the Luen…
A novel evaluation model for hybrid power system based on vague set and Dempster-Shafer evidence theory
2012
Published version of an article from the journal: Mathematical Problems in Engineering. Also available from the publisher:http://dx.doi.org/10.1155/2012/784389 Because clean energy and traditional energy have different advantages and disadvantages, it is of great significance to evaluate comprehensive benefits for hybrid power systems. Based on thorough analysis of important characters on hybrid power systems, an index system including security, economic benefit, environmental benefit, and social benefit is established in this paper. Due to advantages of processing abundant uncertain and fuzzy information, vague set is used to determine the decision matrix. Convert vague decision matrix to …
Stability andl1-Gain Analysis for Positive 2D Systems with State Delays in the Roesser Model
2013
This paper considers the problem of delay-dependent stability andl1-gain analysis for positive 2D systems with state delays described by the Roesser model. Firstly, the copositive-type Lyapunov function method is used to establish the sufficient conditions for the addressed positive 2D system to be asymptotically stable. Then,l1-gain performance for the system is also analyzed. All the obtained results are formulated in the form of linear matrix inequalities (LMIs) which are computationally tractable. Finally, an illustrative example is given to verify the effectiveness of the proposed results.
Adaptive H ∞ synchronization of master-slave systems with mixed time-varying delays and nonlinear perturbations: An LMI approach
2011
Published version of an article in the journal: International Journal of Automation and Computing. Also available from the publisher on SpringerLink: http://dx.doi.org/10.1007/s11633-011-0595-z This paper proposes an adaptive synchronization problem for the master and slave structure of linear systems with nonlinear perturbations and mixed time-varying delays comprising different discrete and distributed time delays. Using an appropriate Lyapunov-Krasovskii functional, some delay-dependent sufficient conditions and an adaptation law including the master-slave parameters are established for designing a delayed synchronization law in terms of linear matrix inequalities(LMIs). The time-varying…
Robust Observer Design for Takagi-Sugeno Fuzzy Systems with Mixed Neutral and Discrete Delays and Unknown Inputs
2012
Published version of an article from the journal: Mathematical Problems in Engineering. Also available from the publisher:http://dx.doi.org/10.1155/2012/635709 A robust observer design is proposed for Takagi-Sugeno fuzzy neutral models with unknown inputs. The model consists of a mixed neutral and discrete delay, and the disturbances are imposed on both state and output signals. Delay-dependent sufficient conditions for the design of an unknown input T-S observer with time delays are given in terms of linear matrix inequalities. Some relaxations are introduced by using intermediate variables. A numerical example is given to illustrate the effectiveness of the given results.
Lean metodoloģijas ietekme uz AS HANSA MATRIX darbības efektivitāti
2016
Maģistra darba tēma ir “Lean metodoloģijas ietekme uz AS HansaMatrix darbības efektivitāti”. Problēmas būtība ir tāda, ka AS HansaMatrix darbības efektivitāte pēc Lean ieviešanas nav tikusi veikta. Darba mērķis ir novērtēt AS HansaMatrix darbības efektivitāti pēc Lean metodoloģijas ieviešanas un izstrādāt priekšlikumus nepilnību novēršanai. Darba uzdevumi: •apkopot informāciju par Lean būtību, ieviešanas principiem un instrumentiem; •veikt AS HansaMatrix novērtējumu pirms un pēc Lean ieviešanas; •saskaņā ar iegūtajiem rezultātiem, izstrādāt secinājumus un priekšlikumus AS Hansamatrix darbības efektivitātes novērtēšanas veikšanas rezultātā tika atklātas problēmas saistībā ar produktu ražošan…