Search results for "Matrix"

Mating-induced differential peptidomics of neuropeptides and protein hormones in Agrotis ipsilon moths

2018

International audience; In many insects, mating induces drastic changes in male and female responses to sex pheromones or host-plant odors. In the male moth Agrotis ipsilon, mating induces a transient inhibition of behavioral and neuronal responses to the female sex pheromone. As neuropeptides and peptide hormones regulate most behavioral processes, we hypothesize that they could be involved in this mating-dependent olfactory plasticity. Here we used next-generation RNA sequencing and a combination of liquid chromatography, matrix assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, and direct tissue profiling to analyze the transcriptome and peptidome of diffe…

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

2010

Upon entry into the central nervous system (CNS), serum insulin-like growth factor-1 (IGF-I) modulates neuronal growth, survival, and excitability. Yet mechanisms that trigger IGF-I entry across the blood-brain barrier remain unclear. We show that neuronal activity elicited by electrical, sensory, or behavioral stimulation increases IGF-I input in activated regions. Entrance of serum IGF-I is triggered by diffusible messengers (i.e., ATP, arachidonic acid derivatives) released during neurovascular coupling. These messengers stimulate matrix metalloproteinase-9, leading to cleavage of the IGF binding protein-3 (IGFBP-3). Cleavage of IGFBP-3 allows the passage of serum IGF-I into the CNS thro…

RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin

2005

The ORF15 isoform of RPGR (RPGR(ORF15)) and RPGR interacting protein 1 (RPGRIP1) are mutated in a variety of retinal dystrophies but their functions are poorly understood. Here, we show that in cultured mammalian cells both RPGR(ORF15) and RPGRIP1 localize to centrioles. These localizations are resistant to the microtubule destabilizing drug nocodazole and persist throughout the cell cycle. RPGR and RPGRIP1 also co-localize at basal bodies in cells with primary cilia. The C-terminal (C2) domain of RPGR(ORF15) (ORF15(C2)) is highly conserved across 13 mammalian species, suggesting that it is a functionally important domain. Using matrix-assisted laser desorption ionization time-of-flight mas…

Generalized centro-invertible matrices with applications

2014

Centro-invertible matrices are introduced by R.S. Wikramaratna in 2008. For an involutory matrix R, we define the generalized centro-invertible matrices with respect to R to be those matrices A such that RAR = A^−1. We apply these matrices to a problem in modular arithmetic. Specifically, algorithms for image blurring/deblurring are designed by means of generalized centro-invertible matrices. In addition, if R1 and R2 are n × n involutory matrices, then there is a simple bijection between the set of all centro-invertible matrices with respect to R1 and the set with respect to R2.

Stability analysis of neutral systems with mixed time-varying delays and nonlinear perturbations

2009

In this paper, the problem of stability analysis for a class of neutral systems with mixed time-varying neutral, discrete and distributed delays and nonlinear perturbations are addressed. By introducing a novel Lyapunov-Krasovskii functional and combining the descriptor model transformation, the Leibniz-Newton formula, some free weighting matrices and a suitable change of variables, new sufficient conditions are established for the stability of the considered system, which are neutral-delay-dependent, discrete-delay-range-dependent and distributed-delay-dependent. The conditions are presented in terms of linear matrix inequalities (LMIs) and can be easily solved by existing convex optimizat…

Approximate Osher–Solomon schemes for hyperbolic systems

2016

This paper is concerned with a new kind of Riemann solvers for hyperbolic systems, which can be applied both in the conservative and nonconservative cases. In particular, the proposed schemes constitute a simple version of the classical Osher-Solomon Riemann solver, and extend in some sense the schemes proposed in Dumbser and Toro (2011) 19,20. The viscosity matrix of the numerical flux is constructed as a linear combination of functional evaluations of the Jacobian of the flux at several quadrature points. Some families of functions have been proposed to this end: Chebyshev polynomials and rational-type functions. Our schemes have been tested with different initial value Riemann problems f…

2019

We consider the network of 5 416 537 articles of English Wikipedia extracted in 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network between all 425 nodes taking into account all direct and indirect links with pathways via the huge global network. PageRank and CheiRank algorithms are used to determine the most influential diseases with the top PageRank diseases being Tuberculosis, HIV/AIDS, and Malaria. From the reduced Google matrix, we determine the sensitivity of world countries to specific diseases integrating th…

World Influence of Infectious Diseases from Wikipedia Network Analysis

2019

AbstractWe consider the network of 5 416 537 articles of English Wikipedia extracted in 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network between all 425 nodes taking into account all direct and indirect links with pathways via the huge global network. PageRank and CheiRank algorithms are used to determine the most influential diseases with the top PageRank diseases being Tuberculosis, HIV/AIDS and Malaria. From the reduced Google matrix we determine the sensitivity of world countries to specific diseases integrat…

Contagion in Bitcoin Networks

2019

12 pages, 6 figures. Paper accepted in 2nd Workshop on Blockchain and Smart Contract Technologies (BSCT 2019), workshop satellite of 22nd International Conference on Business Information Systems (BIS 2019); International audience; We construct the Google matrices of bitcoin transactions for all year quarters during the period of January 11, 2009 till April 10, 2013. During the last quarters the network size contains about 6 million users (nodes) with about 150 million transactions. From PageRank and CheiRank probabilities, analogous to trade import and export, we determine the dimensionless trade balance of each user and model the contagion propagation on the network assuming that a user go…

Novel Version of PageRank, CheiRank and 2DRank for Wikipedia in Multilingual Network Using Social Impact

2020

International audience; Nowadays, information describing navigation behaviour of internet users are used in several fields, e-commerce, economy, sociology and data science. Such information can be extracted from different knowledge bases, including business-oriented ones. In this paper, we propose a new model for the PageRank, CheiRank and 2DRank algorithm based on the use of clickstream and pageviews data in the google matrix construction. We used data from Wikipedia and analysed links between over 20 million articles from 11 language editions. We extracted over 1.4 billion source-destination pairs of articles from SQL dumps and more than 700 million pairs from XML dumps. Additionally, we …