Search results for "Maxim"

La implicatura en los blogs educativos. Una aproximación pragmática

2015

[ES] La tecnología está multiplicando las formas en que podemos comunicarnos. Desde la aparición de Internet, la construcción del discurso, los géneros discursivos y el lenguaje mismo se han visto afectados por las características de este nuevo modo de comunicarse. Aparecen discursos mixtos que hacen necesarios nuevos enfoques. Así, el estudio de la red desde una perspectiva pragmática ha abarcado diferentes aproximaciones (el género, la caracterización del lenguaje de los textos, etc.); los blogs han sido considerados como una forma de conversación. El presente trabajo estudia los blogs educativos desde el punto de vista de las máximas conversacionales de Grice, y, en particular, las impli…

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

Transition-Edge Sensors for Particle Induced X-ray Emission Measurements

2013

In this paper we present a new measurement setup, where a transitionedge sensor detector array is used to detect X-rays in particle induced X-ray emission measurements with a 2 MeV proton beam. Transition-edge sensors offer orders of magnitude improvement in energy resolution compared to conventional silicon or germanium detectors, making it possible to recognize spectral lines in materials analysis that have previously been impossible to resolve, and to get chemical information from the elements. Our sensors are cooled to the operation temperature (65 mK) with a cryogen-free adiabatic demagnetization refrigerator, which houses a specially designed X-ray snout that has a vacuum tight window…

5 Effects Of Low-intensity Concentric Combined With Blood Flow Restriction On Achilles Tendon

2014

Introduction Weight training is a useful tool in order to achieve muscular hypertrophy. However, the American College of Sports Medicine (ACSM) recommends intensities of 70% of one repetition maximum (1-RM). Those intensities may not be suitable for everyone because of the high mechanical stresses placed upon the joints [Loenneke, 2012]. Nowadays, it is common to combine low-intensity exercise (20–30% 1-RM) with blood flow restriction (BFR) because of the beneficial effects in increased muscular strength, hypertrophy, localised endurance and cardiorespiratory endurance [Pope, 2013]. Despite there is not many papers about the beneficial of this training, it is know that the tendon suffers so…

2017

Creatine kinase (CK) is a marker for muscle cell damage with limited potential as marker for training load in strength training. Recent exercise studies identified cell free DNA (cfDNA) as a marker for aseptic inflammation and cell damage. Here we overserved in a pilot study the acute effects during strength exercise and chronic effects of regular strength training on cfDNA concentrations over a period of four weeks in three training groups applying conservation training (CT) at 60% of the 1 repetition maximum, high intensity-low repetition training (HT) at 90% of the 1 repetition maximum and differential training (DT) at 60% of the 1 repetition maximum. EDTA-plasma samples were collected b…

Improved Performance of a PV Solar Panel with Adaptive Neuro Fuzzy Inference System ANFIS based MPPT

2018

This article presents the development of an intelligent technique of Adaptive-Neuro-Fuzzy Inference System (ANFIS) based on Maximum Power Point Tracking (ANFIS-MPPT) algorithm with PI controller in order to increase the performances of the photovoltaic panel system below change atmospheric circumstances. In this work, the mathematical principles of the ANFIS method were presented and developed using the software Matlab/Simulink. Moreover, the effectiveness of this ANFIS-MPPT technique is demonstrated by a comparison of the obtained results with others obtained from a classical (Perturb & Observe) P & O-MPPT method.From the analysis of the obtained results, the ANFIS-MPPT command provide bet…

The Effect of Natural Allergen Exposure on the Maximal Response Plateau to Adenosine 5′-monophosphate and on Exhaled Nitric Oxide of Alveolar and Bro…

2010

Effects of gait speed on stability of walking revealed by simulated response to tripping perturbation

2013

The objective of this work was to study stability of walking over a range of gait speeds by means of muscle-driven simulations. Fast walking has previously been related to high likelihood of falling due to tripping. Various measures of stability have shown different relationships between walking speed and stability. These measures may not be associated with tripping, so it is unclear whether the increase in likelihood of falling is explicable by an increase in instability. Here, stability with respect to a constant tripping perturbation was quantified as the immediate passive response of torso to the perturbation. Subject-specific muscle-driven simulations of eight young healthy subjects wa…

La Adoración de los Magos. Imagen de la Epifanía en el arte de la Antigüedad

1992

Análisis e interpretación iconográfica de la Adoración de los magos en el arte de los primeros siglos. Como tipo iconográfico, la Adoración de los Magos es considerada en el momento y circunstancias en que fue creado y difundido, contrastándolo con sus homólogas paganas como tema de encuadre. Siguiendo los procedimientos de la iconografía-iconología tradicional, se explican intertextualmente representaciones pictóricas de las catacumbas, esculturas de los sarcófagos y otras manifestaciones. Su sentido es puesto en relación con textos de las Escrituras, la liturgia, sermones y tratados teológicos, dirigido todo hacia una comprensión hermenéutica. Iconographic analysis and interpretation of t…

Exposure assessment of fruits contaminated with pesticide residues from Valencia, 2001– 03

2006

A total of 634 samples of oranges, tangerines, peaches, nectarines, khakis and watermelons were collected from an Agricultural Valencia Community Cooperative during the May 2001 to April 2003 campaigns and they were analysed for 15 pesticides among those recommended for pest treatment. A conventional multiresidue analytical procedure based on ethyl acetate extraction was used followed by gas chromatography coupled to a nitrogen phosphorus detector for routine analysis; and mass spectrometry was performed for confirmation. Recovery studies with spiked samples at 0.5 mg kg-1 for each pesticide ranged from 52% for acephate to 87% for fenthion with a standard deviation20%. Limits of quantificat…