Search results for "Measurement"
showing 10 items of 2918 documents
Speech treatment in nemaline myopathy: A single-subject experimental study
2020
Abstract Purpose The objective of this work was to verify the efficacy of a treatment based on myofunctional therapy techniques which aimed to improve the tongue strength, precision, and speed of a ten-year-old girl with nemaline myopathy (NM) and the repercussions of this therapy on her speech intelligibility. NM is a rare congenital muscle disorder that causes extreme muscle weakness, especially in the face and neck, as well as severe dysarthria and dysphagia, although this does not affect the nervous system or cognitive development. Method This was a single-subject experimental study which used an interrupted pre- and post-treatment time-series design, and which applied autoregressive in…
An anti-inflammatory ditriazine inhibiting leukocyte functions and expression of inducible nitric oxide synthase and cyclo-oxygenase-2.
2000
A ditriazine derivative (4,10-dichloropyrido[5,6:4,5]thieno[3,2-d':3, 2-d]-1,2,3-ditriazine (DTD)) inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B(4) production, without any effect on 5-lipoxygenase activity. This compound reduced nitric oxide (NO) and prostaglandin E(2) production in mouse peritoneal macrophages stimulated with lipopolysaccharide, whereas no influence on the activity of inducible NO synthase, cyclo-oxygenase-2 or cyclo-oxygenase-1 was observed. DTD significantly reduced mouse paw oedema induced by carrageenan and also markedly reduced NO and prostaglandin E(2) levels in exudates from 24-h zymosan-stimulated mouse air pouch.…
Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte formations and experimental inflammation.
2001
A number of pyrido[1,2-c]pyrimidines bearing a nitrogen, oxygen, or sulfur functionality at C-1 were synthesized on solid-phase using the iminophosphorane methodology and tested for their effects on leukocyte functions in vitro and antiinflammatory activity. Compound 5c was found to be a strong scavenger of superoxide anion and an inhibitor of chemiluminescence induced by 12-O-tetradecanoylphorbol 13-acetate in human neutrophils. These pyrido[1,2-c]pyrimidines inhibited the generation of PGE(2) by COX-2 in RAW 264.7 macrophages stimulated with lipopolysaccharide. Compounds 7, 5f, 6, and 8 inhibited enzyme activity, whereas the remaining compounds also acted on the induction phase. In additi…
A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats
2003
AbstractThe synthetic chalcone derivative 1-(2,4-dichlorophenyl)-3-(3-(6,7-dimethoxy-2-chloroquinolinyl))-2-propen-1-one (CIDQ) was evaluated for its anti-inflammatory, analgesic and immunomodulatory efficacy in-vitro and in-vivo. CIDQ concentration-dependently inhibited the production of nitric oxide (NO) (IC50 4.3 μM) and prostaglandin E2 (PGE2) (IC50 1.8 μM) in RAW 264.7 macrophages stimulated with lipopolysaccharide. Human mononuclear cell proliferation was significantly inhibited by 10 μM CIDQ. Oral administration of CIDQ (10–30 mg kg−1) in the 24-h zymosan-stimulated mouse air-pouch model produced a dose-dependent reduction of cell migration as well as NO and PGE2 levels in exudates. …
6-Dimethylamino 1H-pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells.
2003
The synthesis of 6-dimethylamino 1H-pyrazolo[3,4-d]pyrimidines substituted at positions 1 and 4, and their effects on murine macrophage and human neutrophil functions are described. Several compounds and especially 4b-6b are potent inhibitors of PGE2 generation in murine macrophages. This action is related to a direct effect on COX-2 activity without affecting the enzyme expression. Some of these compounds also inhibited COX-1 and COX-2 in human monocytes and 4b showed selectivity for COX-2 inhibition. © 2003 Elsevier Science Ltd. All rights reserved.
The anti-inflammatory and antinociceptive effects of NF-κB inhibitory guanidine derivative ME10092
2010
The guanidine compound ME10092 (1-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine) is known to possess anti-radical and anti-ischemic activity but its molecular targets have not been identified. This study investigated whether ME10092 regulates the nuclear factor kappa B (NF-kappaB)-mediated signal transduction in vivo. The effect of ME10092 treatment (1-100 pmol/mouse) on nuclear translocation of NF-kappaB, activation of expression of inflammatory mediators and production of nitric oxide were measured in the lipopolysaccharide (LPS)-induced brain inflammation model in mice in vivo. The antinociceptive activity of ME10092 was tested in the formalin-induced paw licking test. ME10092 dose-…
Weld pool surface temperature measurement from polarization state of thermal emission
2014
This paper presents a passive polarimetry method using a division of aperture optical device in order to measure the temperature distribution at the weld pool surface. Thermal emission from a hot liquid metal was investigated at a near-infrared wavelength corresponding to a blind spectral window of a helium plasma generated during gas tungsten arc welding process. The refractive index of liquid metal and the surface radiance are deduced from the polarisation state of thermal emissions. Based upon the knowledge of both characteristics, the temperature distribution can be calculated. Conseil Régional de Bourgogne
Experimental study of bubble detection in liquid metal.
2017
International audience; Bubble detection in liquid metal is an important issue for various technological applications. For instance, in the framework of Sodium Fast Reactors design, the presence of gas in the sodium flow of the primary and secondary loops is an issue of crucial importance for safety and reliability. Here, the two main gas measurement methods in sodium are ultrasonic testing and eddy-current testing; we investigate the second method in our study. In a first approach, we have performed experiments with liquid metal galinstan containing insulating spherical beads of millimeter size. The liquid metal is probed with an Eddy-current Flowmeter (ECFM) in order to detect the beads a…
The Design and Sensitivity of JUNO's scintillator radiopurity pre-detector OSIRIS
2021
The European physical journal / C 81(11), 973 (2021). doi:10.1140/epjc/s10052-021-09544-4
The Ancient Commentators of Plato and Aristotle
2009
In late antiquity the works of Plato and Aristotle were subject to intense study, which eventually led to the development of a new literary form, the philosophical commentary. Until recently these commentaries were understood chiefly as sources of information for the masters, Plato and Aristotle, they commented upon. However, in recent years, it has become increasingly acknowledged that the commentators themselves - Aspasius, Alexander, Themistius, Porphyry, Proclus, Philoponus, Simplicius and others - even though they worked in the Platonist-Aristotelian framework, contributed to this tradition in original, innovative and significant ways such that their commentaries are philosophically im…