Search results for "Mebendazole"

showing 3 items of 3 documents

Hepatotoxicity caused by mebendazole in a patient with Gilbert's syndrome

2019

What is known and objective Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's syndrome affected by pinworms infestation. Case summary Differently from other cases of hepatitis due to MBZ reported in the scientific literature, our patient received standard doses of MBZ for a short period of time. After 18 days from the start of therapy, he developed hepatomegaly, and increases in hepatic enzymes and bilirubin. Hepatic enzymes returned to normal over the foll…

medicine.medical_specialtyGlucuronosyltransferaseSettore MED/17 - Malattie InfettiveBilirubinMebendazoleGlucuronidation030226 pharmacology & pharmacyGastroenterology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicineMedicinePharmacology (medical)030212 general & internal medicinePharmacologyHepatitisLiver injurybiologybusiness.industrydrug toxicity Gilbert's syndrome hepatitis mebendazolemedicine.diseaseAntihelminthic AgentGilbert's syndromechemistrySettore BIO/14 - Farmacologiabiology.proteinbusinessmedicine.drugJournal of Clinical Pharmacy and Therapeutics
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Human Bertiella studeri in Spain, Probably of African Origin

1997

A mature tapeworm and gravid proglottids of Bertiella studeri were reported from the stools of a 33-year-old pregnant Spanish woman. The patient had spent the six months preceding this discovery in Kenya. The evidence suggests a case of parasitism imported to Spain from the African continent. The patient presented no symptoms related to the parasite and the discovery in stools of a number of active, white structures led her to collect them. A morphologic and morphometric description of the material obtained is presented. Mebendazole failed to remove the parasite but niclosamide was effective.

AdultPathologymedicine.medical_specialtyMebendazoleParasitismZoologyAfrican originPregnancyVirologymedicineAnimalsHumansParasite hostingNiclosamideTravelbusiness.industryAnticestodal AgentsCestode InfectionsInfectious DiseasesSpainPregnancy Complications ParasiticAfricaBertiella studeriCestodaNiclosamideFemaleParasitologybusinessmedicine.drugThe American Journal of Tropical Medicine and Hygiene
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Analysis of mebendazole binding to its target biomolecule by laser flash photolysis

2016

[EN] Mebendazole (MBZ) and related anticancer benzimidazoles act binding the beta-subunit of Tubulin (TU) before dimerization with alpha-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a new tool to investigate drug-albumin interactions and to determine binding parameters such as affinity constant or population of binding sites. The aim of this study was to evaluate the interactions between the nonfluorescent mebendazole (MBZ) and its target biomolecule TU using this technique. Before analyzing the MBZ@TU complex it was needed to determine the photophysical properties of MBZ triplet excited state ((3)MBZ*) in different media. Hence, 3MBZ* showed a transien…

PopulationBiophysicsBinding constantElectron donor010402 general chemistryPhotochemistry01 natural sciencesAnticancer drugschemistry.chemical_compoundQUIMICA ORGANICAMebendazole triplet excited stateTubulinUltrafast laser spectroscopyRadiology Nuclear Medicine and imagingeducationchemistry.chemical_classificationeducation.field_of_studyRadiationPhotolysisRadiological and Ultrasound Technology010405 organic chemistryPhosphorescenceLasersPhotodissociationTemperatureLaser flash photolysisElectron acceptorBinding constant0104 chemical sciencesMebendazolechemistryExcited stateFlash photolysisThermodynamicsSpectrophotometry UltravioletProtein Binding
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