Search results for "Meda"
showing 10 items of 593 documents
Can QCD Axion Stars explain Subaru HSC microlensing?
2021
A non-negligible fraction of the QCD axion dark matter may form gravitationally bound Bose Einstein condensates, which are commonly known as axion stars or axion clumps. Such astrophysical objects have been recently proposed as the cause for the single candidate event reported by Subaru Hyper Suprime-Cam (HSC) microlensing search in the Andromeda galaxy. Depending on the breaking scale of the Peccei-Quinn symmetry and the details of the dark matter scenario, QCD axion clumps may form via gravitational condensation during radiation domination, in the dense core of axion miniclusters, or within axion minihalos around primordial black holes. We analyze all these scenarios and conclude that the…
Consequências mal adaptativas de invasões mentais com conteúdos relacionados a transtornos obsessivos, dismórficos, hipocondríacos e alimentares: dif…
2021
Unwanted mental intrusions (UMIs) with contents related to Obsessive-Compulsive Disorder (OCD), Body Dysmorphic Disorder (BDD), Illness Anxiety Disorder (IAD), and Eating Disorders (EDs) are highly prevalent, independently of the cultural and/or social context. Cognitive-behavioral explanations for these disorders postulates that the escalation from common UMIs to clinically relevant symptoms depends on the maladaptive consequences (i.e., emotions, appraisals, and control strategies) of experiencing UMIs. This study examines, from a cross-cultural perspective, the cognitive-behavioral postulates of the maladaptive consequences of having UMIs.Non-clinical 1,473 participants from Europe, the …
Critical factors influencing international sporting success of the Philippines : the athletes' perspective
2017
The aim of this study is to contribute to the understanding of the recent declining performance of the Philippines in international sporting competitions by identifying and evaluating relevant factors that are critical to its international success through the perspective of the national elite athletes. An evaluation of the organizational effectiveness of the national sports governing bodies provides explanation to the poor performance of the country in major international competitions such as the Southeast Asian (SEA)Games. One of the most recent approaches used in measuring organizational effectiveness is the Sport Policy factors Leading to International Sporting Success (SPLISS) model. Th…
Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist
2015
Chronic obstructive pulmonary disease (COPD) is characterised by chronic pulmonary inflammation punctuated by periods of viral exacerbations. Recent evidence suggests that the combination of roflumilast with corticosteroids may improve the compromised anti-inflammatory properties of corticosteroids in COPD. We analyzed differential and combination anti-inflammatory effects of dexamethasone and roflumilast N-oxide in human bronchial epithelial cells (HBECs) stimulated with viral toll like receptor (TLR) agonists. Lung tissue and HBECs were isolated from healthy (n = 15), smokers (n = 12) and smokers with COPD (15). TLR3 expression was measured in lung tissue and in HBECs. IL-8 secretion was …
Búsqueda de compuestos con potencial terapéutico para la enfermedad de Parkinson y estudio de la relación entre la enfermedad de Parkinson y la Diabe…
2022
La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más frecuente. Actualmente, la EP no tiene cura, y las terapias existentes solo son capaces de tratar los síntomas de esta enfermedad, pero no de ralentizar o de parar su progresión. Con el objetivo de descubrir nuevos fármacos que pudieran ser útiles para tratar esta enfermedad, hemos realizado un rastreo a gran escala, evaluando los compuestos incluidos en la quimioteca Prestwick (1120 compuestos). Para ello, estudiamos el efecto de estos compuestos sobre la actividad motora en un modelo de la EP en Drosophila basado en la mutación del gen DJ-1beta (ortólogo del gen humano DJ-1, cuya mutación es causante de casos f…
Identificación de nuevas rutas de patogénesis y dianas terapéuticas en la enfermedad de Parkinson mediante el uso de modelos biomédicos
2022
La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común, caracterizada por la pérdida progresiva de neuronas dopaminérgicas en la substantia nigra pars compacta. Esto conduce a una disminución de los niveles de dopamina en el núcleo estriado, causando los síntomas motores típicos de la enfermedad. Entre las principales causas de la neurodegeneración se encuentran el estrés oxidativo (EO) y la disfunción mitocondrial. Aunque la mayoría de los casos de EP son idiopáticos, se ha demostrado que entre el 5 y el 10% de ellos son formas familiares de la enfermedad causadas por mutaciones en determinados genes. Uno de ellos es el gen DJ-1, cuyas mutaciones están asociad…
Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale…
2021
BACKGROUND: The European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated, widely used tool developed to score the clinical benefit from cancer medicines reported in clinical trials. ESMO-MCBS scores assume valid research methodologies and quality trial implementation. Studies incorporating flawed design, implementation, or data analysis may generate outcomes that exaggerate true benefit and are not generalisable. Failure to either indicate or penalise studies with bias undermines the intention and diminishes the integrity of ESMO-MCBS scores. This review aimed to evaluate the adequacy of the ESMO-MCBS to address bias generated by flawed design, im…
Zvaigžņotā Debess: 2011, Vasara (212)
2011
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. Extremely Distant New Objects of Metagalaxy (abridged) ; Newspaper „Literaturnaja Rossija” 9 April 1971. Astronautics: Yesterday, Today, Tomorrow (abridged) ; CONFERENCE “The VIEW from SPACE. FIRST MANNED SPACE FLIGHT – 50”: M.Gills. Conference on the Eve of Human Space Flight Anniversary ; J.Ekmanis, S.Negrejeva. Mstislav Keldysh and Golden Age of Soviet Science ; T.Millers. Contribution of Scientists of the Institute of Inorganic Chemistry to the Development of Space Technologies and Materials ; G.Vilka. Remembrance of Friedrich Zander in Rīga ; O.Plepis. My Contribution to the Development of Space Medicine ; J.Stradiņš. Latvia’s …
Presenting signs and patient co-variables in Gaucher disease: outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative.
2019
Background: Gaucher disease (GD) presents with a range of signs and symptoms. Physicians can fail to recognise the early stages of GD owing to a lack of disease awareness, which can lead to significant diagnostic delays and sometimes irreversible but avoidable morbidities. Aim: The Gaucher Earlier Diagnosis Consensus (GED-C) initiative aimed to identify signs and co-variables considered most indicative of early type 1 and type 3 GD, to help non-specialists identify ‘at-risk’ patients who may benefit from diagnostic testing. Methods: An anonymous, three-round Delphi consensus process was deployed among a global panel of 22 specialists in GD (median experience 17.5 years, collectively managin…
Spatio-temporal analysis of infectious diseases
2018
Los sistemas de vigilancia de salud pública colectan y analizan datos que soportan los programas de control y prevención de enfermedades en todo el mundo. En Colombia, el sistema de vigilancia en salud pública (SIVIGILA) esta encargado del flujo de datos e información de la vigilancia de las enfermedades de notificación obligatoria que afectan la salud de los Colombianos. Las enfermedades transmitidas por mosquitos tales como el dengue, la malaria, la fiebre amarilla, la enfermedad del virus del Chikungunya, la enfermedad del virus del Zika (EVZ) entre otras afectan seriamente la salud de las poblaciones a través de todo el país. Dentro de estas enfermedades se destacan la enfermedad del de…