Search results for "Mediator"

Self-interacting dark matter and cosmology of a light scalar mediator

2015

We consider a fermionic dark matter candidate interacting via a scalar mediator coupled with the Standard Model through a Higgs portal. We consider general setting including both scalar and pseudoscalar interactions between the scalar and fermion, and illustrate the relevant features for dark matter abundance, direct search limits and collider constraints. The case where dark matter has a self-interaction strength $\left\langle \sigma_V \right\rangle/m_\psi \sim 0.1-1 \,\mathrm{cm}^2/\mathrm{g}$ is strongly constrained, in particular by the Big Bang Nucleosynthesis. We show that these constraints can be alleviated by introducing a new light sterile neutrino $N$. The allowed region for the e…

Isolement et caractérisation de saponosides extraits de deux plantes médicinales : Cyclamen africanum, Zygophyllum cornutum et évalution de leur acti…

2014

The appearance of several diseases, such as cancer, diabetes, high blood pressure and spread of infections mutagenic virus type can be linked to the quality and lifestyle that we lead today. Indeed, several studies on the factors triggering these so-called "morbid" long-or short-term illnesses are related to stress and quality of food consumed, whether of plant and animal origin. These diseases are becoming a common occurrence, they affect different races and all classes of society. According ethnobotanical research, naturally occurring substances, allowed civilizations to survive deadly diseases. For example, we thus find references to periods of malarial fever in China and one of the symp…

Polysubstituted ferrocenes as tunable redox mediators

2018

A series of four ferrocenyl ester compounds, 1-methoxycarbonyl- (1), 1,1’-bis(methoxycarbonyl)- (2), 1,1’,3-tris(methoxycarbonyl)- (3) and 1,1’,3,3’-tetrakis(methoxycarbonyl)ferrocene (4), has been studied with respect to their potential use as redox mediators. The impact of the number and position of ester groups present in 1–4 on the electrochemical potential E1/2 is correlated with the sum of Hammett constants. The 1/1+–4/4+ redox couples are chemically stable under the conditions of electrolysis as demonstrated by IR and UV–vis spectroelectrochemical methods. The energies of the C=O stretching vibrations of the ester moieties and the energies of the UV–vis absorptions of 1–4 and 1+–4+ c…

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

2019

Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…

Comunicare per comprendere, comprendersi incontrarsi. Quale formazione per i mediatori interculturali?

2016

Il saggio analizza ruoli e funzioni del mediatore interculturale, individuando conoscenze e competenze professionali specifiche e ipotizzando percorsi formativi adeguati. In particolare si sofferma sulle competenze relative alle capacità di ascolto, di empatia, di entrare in relazione attraverso il canale verbale e non verbale e sulla necessità di un percorso centrato anche sullo sviluppo della consapevolezza di sé per potere entrare in contatto con l'altro.

Cultural similarity and dissimilarity in intercultural conflicts

2015

This study investigated cultural similarity and dissimilarity in intercultural conflicts, by focusing on how a mediator understands cultural difference in the process of mediation. Intercultural conflict occurs when cultural worldviews of an individual or group are incompatible with the worldviews of another cultural group within the same community. Special interest has been on social inequality, stereotypes and ingroup outgroup tension as causes of intercultural conflicts. Participants for this study were qualified mediators from South Africa. In order to understand their practice environment and mediation landscape in general, community conflict in South Africa was studied. The findings r…

Le tecniche del mediatore

2011

Ultraviolet A1 radiation induces nitric oxide synthase-2 expression in human skin endothelial cells in the absence of proinflammatory cytokines.

2001

Skin exposure to ultraviolet radiation from sunlight causes erythema and edema formation as well as inflammatory responses. As some of these ultraviolet-induced effects are potentially mediated by nitric oxide synthases, we examined the role of cytokines and ultraviolet A 1 radiation (340–400 nm) on the expression of the nitric oxide synthase-2 in endothelia of normal human skin biopsies during short-term organ culture as well as expression and activity of the nitric oxide synthase-2 in in vitro cell cultures of human dermal endothelial cells. Both, cytokine challenge (interleukin-1β + tumor necrosis factor-α + interferon-γ) but also ultraviolet A 1 exposure (50 J per cm 2 ) in the absence …

Zirga simbolika latviešu folklorā

2016

Bakalaura darbs ir pētījums par zirga simboliku un funkcijām latviešu folklorā, akcentējot tautasdziesmu tekstus. Darbam ir divas nodaļas ar apakšnodaļām. Pētnieciskā darba mērķis ir latviešu folkloras materiālā rast kopējo priekšstatu par zirgu, tā lomu un nozīmi tradicionālajā sabiedrībā caur tā simboliku un raksturot to tematiskos blokos, tādā veidā nodalot tā funkcionalitāti. Pētnieciskā mērķa īstenošanai autore pastiprināti pievērsusies tautasdziesmu tekstu simbolikai. Darba gaitā secināts, ka zirga pastāvīgā klātbūtne arhaiskā cilvēka apziņā ir ne tikai cēlusi zirga statusu, padarot to par auglības un darba simbolu, bet arī pielīdzinājusi un piedēvējusi zirgu dievību pasaulei kā pastā…