Search results for "MerA"
showing 10 items of 3426 documents
Priekšējās kameras kakta novērtēšana ar optiskās koherences tomogrāfu
2020
Bakalaura darbs uzrakstīts latviešu valodā uz 25 lapaspusēm, tas satur 6 tabulas, 19 attēlus un 30 literatūras atsauces. Pētījuma mērķis bija izpētīt acs priekšējā kameras kakta struktūras atvērta un slēgta kakta glaukomas gadījumos, un sakarību starp acs priekšējā kameras kakta leņķi un varavīksnenes saknes formu. Tika analizēti 311 vienas līnijas OCT attēli no oftalmologa privātprakses, kas tika iedalīti vairākās grupās: NORM (bez acu saslimšanām), PAKG1 (primāra atvērta kakta glaukoma 1. stadijā), PAKG2 (primāra atvērta kakta glaukoma 2. stadijā), PAKG3 (primāra atvērta kakta glaukoma 3. stadijā) un SAKG (slēgta atvērta kakta glaukoma) tika analizētas varavīksnenes saknes formas (VSF) un…
Réflexions sur l'utilisation culinaire des mortiers protohistoriques en céramique : le cas du Languedoc méditerranéen à l'âge du Fer (VIe-IIIe s. av.…
2009
International audience; En el siglo VI a. C., el mortero aparece en la batería de cocina del Languedoc y del Rosellón mediterráneos. En un principio importado, antes de ser fabricado en la región, ha sido considerado a veces como un indicador de prácticas culinarias exógenas. En realidad el uso de este utensilio, bastante frecuente, estaria más bien relacionado con el desarrollo del consumo del vino en la Galia meridional durante la primera edad del Hierro. Efectivamente, el mortero pudo haber sido utilizado para triturar condimentos o plantas aromáticas participando así en la preparación de esta bebida.; Au VIe s. av. n. ère, le mortier fait son introduction dans la batterie de cuisine ind…
Zirgkastaņu raibkodes Cameraria ohridella Deschka et Dimić populācijas dinamika un to ietekmējošais parazitoīdu sugu komplekss
2015
Zirgkastaņu raibkode Cameraria ohridella (Lepidoptera: Gracillariidae) ir invazīva suga, kas izraisa lapotnes defoliāciju parastā zirgkastaņa Aesculus hippocastanum kokiem. Pētījuma mērķis bija apskatīt zirgkastaņu raibkodes populācijas dinamikas attīstību ietekmējošos rādītājus un identificēt raibkodes parazitoīdu sugu kompleksu. Jelgavas pilsētā 2014. gada veģetācijas periodā tika veikta raibkodes radīto lapu bojājumu novērtēšana. Veicot lapu paraugu izpēti un raibkodes īpatņu uzskaiti, tika apskatīta populācijas attīstības dinamika, fenoloģija, mirstības apmēri un noteikti mirstības cēloņi. Izolējot kūniņas, tika novērtēta mātīšu olu dēšanas produktivitāte. Izvietojot kūniņas ziemošanas …
Revista española de educación comparada
2015
El sistema norteamericano de educacion, representa do por las siglas K-12 cosecho impresionantes frutos durante gran parte del siglo pasado. Sus origenes se remontan a principios del siglo XX, cuando las necesidades soc iales y economicas del pais distaban ampliamente de las presentes. Nuestra sociedad actu al, mucho mas compleja, demanda mayor preparacion de la ciudadania, la cual se cimi enta, como demostraremos en este articulo, con una educacion infantil de calidad. Po r este motivo, la mayoria de especialistas en educacion reclaman a las administraciones public as la creacion de un sistema de educacion infantil universal y verdaderamente de ca lidad (no meras guarderias de la infancia)…
The article a(n) in English quantifying expressions: A default marker of cardinality
2020
Certain English quantificational expressions feature what appears to be an indefinite article, e.g. 'a bunch, a few, a hundred'. These can be divided into three types of quantifying expressions: pseudopartitives ('a lot, a bunch, a ton'), article-requiring quantifiers ('a few, a couple, a hundred'), and article-free quantifiers ('three, many, several'); article-free quantifiers have an article under certain circumstances, e.g. modification by an adjective ('a surprising 30 …'). While standard analyses would take the article in these expressions to be a D head, it is argued here that the article is not in D, nor is it singular or count, as evidenced by its (lack of an) interaction with verba…
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations
2020
Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
2012
To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…