Search results for "MerA"

Early numeracy in low‐performing young children

2009

The aim of this study was to explore the early numeracy of low‐performing young children. The mean age of the children was six years and four months. The 511 participants belonged to three groups: multi‐language children, children with special educational needs and children with average performance. The results showed that there were significant group differences in early numeracy: the children in the reference group had better relational and counting skills than those with a multi‐language background and those with special educational needs. Some differences were found in counting skills between the children with multi‐language background and those with special educational needs. Finally, …

Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29

2002

Abstract ERp29 is a soluble protein localized in the endoplasmic reticulum (ER) of eukaryotic cells, which is conserved in all mammalian species. The N-terminal domain of ERp29 displays sequence and structural similarity to the protein disulfide isomerase despite the lack of the characteristic double cysteine motif. Although the exact function of ERp29 is not yet known, it was hypothesized that it may facilitate folding and/or export of secretory proteins in/from the ER. ERp29 is induced by ER stress, i.e. accumulation of unfolded proteins in the ER. To gain an insight into the mechanisms regulating ERp29 expression we have cloned and characterized the rat ERp29 gene and studied in details …

Transcriptional Response of Saccharomyces cerevisiae to Different Nitrogen Concentrations during Alcoholic Fermentation▿ †

2007

Gene expression profiles of a wine strain of Saccharomyces cerevisiae PYCC4072 were monitored during alcoholic fermentations with three different nitrogen supplies: (i) control fermentation (with enough nitrogen to complete sugar fermentation), (ii) nitrogen-limiting fermentation, and (iii) the addition of nitrogen to the nitrogen-limiting fermentation (refed fermentation). Approximately 70% of the yeast transcriptome was altered in at least one of the fermentation stages studied, revealing the continuous adjustment of yeast cells to stressful conditions. Nitrogen concentration had a decisive effect on gene expression during fermentation. The largest changes in transcription profiles were o…

Primeras consideraciones a la Ley Orga?nica 3/2021, de 24 de marzo, de regulación de la eutanasia. el reconocimiento de un nuevo derecho

2021

The aim of this paper is to carry out a brief study of the recent Organic Law 3/2021, of March 24, on the regulation of euthanasia (BOE. March 25, 2021) approved in Spain, from a constitutional perspective, highlighting its main aspects. The matter under study is not exempt from controversy because it covers legal, medical and ethical considerations of great complexity.

Identificación y caracterización de factores implicados en la biogénesis de la RNA polimerasa II en Saccharomyces cerevisiae

2014

INTRODUCCIÓN La transcripción es el proceso de síntesis enzimática de un RNA a partir de una secuencia complementaria de DNA. En eucariotas, la transcripción de los genes que codifican proteínas la lleva a cabo la RNA polimerasa II (RNA pol II), junto con una gran cantidad de factores auxiliares que participan en el proceso actuando a diferentes niveles. Para que la RNA pol II inicie la transcripción se requiere la formación del complejo pre-inicio (PIC). Uno de los pasos clave en la regulación del inicio de la transcripción es la formación del PIC. En este proceso se ha visto implicado el regulador transcripcional NC2 (cofactor negativo 2), que actúa bloqueando el ensamblaje del PIC. Ademá…

ALGO MÁS SOBRE LA FUNCIÓN DEMARCATIVO-INTEGRADORA DE LA ENTONACIÓN: EL CASO DE LAS SERIES ENUMERATIVAS

2008

Tradicionalmente, los estudios prosódicos sobre la enumeración en español han venido basándose en el análisis de grabaciones procedentes de lectura cuidadosa de textos (literarios en muchos casos), sobre la que se ha procedido a detectar las oportunas regularidades (Navarro Tomás 1980; Quilis 1993, o más recientemente, aunque con objetivos muy diferentes, Moreno Fernández 2005). En este sentido desde hace algunos años hemos venido advirtiendo de la necesidad de asumir en la descripción entonativa del español los hábitos propios de la lengua hablada espontánea (Hidalgo 1997, 2006a ó 2006b), puesto que es en el discurso no planificado donde se manifiesta en su integridad la variedad expresiva…

Diversos autors (2003). Luis Simarro i la psicologia científica a Espanya. Cent anys de la primera càtedra de psicologia

2004

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

Erwinia piriflorinigrans sp. nov., a novel pathogen that causes necrosis of pear blossoms

2010

Eight Erwinia strains, isolated from necrotic pear blossoms in València, Spain, were compared with reference strains of Erwinia amylovora and Erwinia pyrifoliae, both of which are pathogenic to species of pear tree, and to other species of the family Enterobacteriaceae using a polyphasic approach. Phenotypic analyses clustered the novel isolates into one phenon, distinct from other species of the genus Erwinia, showing that the novel isolates constituted a homogeneous phenotypic group. Rep-PCR profiles, PCR products obtained with different pairs of primers and plasmid contents determined by restriction analysis showed differences between the novel strains and reference strains of E. amylovo…

Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…

2010

Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…