Search results for "Meri"

showing 10 items of 7596 documents

Nanoparticles of a polyaspartamide-based brush copolymer for modified release of sorafenib: In vitro and in vivo evaluation.

2017

Abstract In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib for the treatment of hepatocellular carcinoma (HCC). A synthetic brush copolymer, named PHEA-BIB-ButMA (PBB), was synthesized by Atom Trasnfer Radical Polymerization (ATRP) starting from the α-poly( N -2-hydroxyethyl)- d , l -aspartamide (PHEA) and poly butyl methacrylate (ButMA). Empty and sorafenib loaded PBB NPs were, then, produced by using a dialysis method and showed spherical morphology, colloidal size, negative ζ potential and the ability to allow a sustained sorafenib release in physiological environment. Sorafenib loaded PBB NPs were tested in vitro on HCC cells in order to e…

3003MaleHepatocellular carcinomamedicine.medical_treatmentPharmaceutical Science02 engineering and technologyATRPPharmacology01 natural sciencesDrug Delivery SystemsCopolymerChemistryATRP; Hepatocellular carcinoma; Sorafenib; Tumor targeting; α-Poly(N-2-hydroxyethyl)-DL-aspartamide; 3003Liver NeoplasmsSorafenib021001 nanoscience & nanotechnologyDrug delivery0210 nano-technologymedicine.drugSorafenibNiacinamideCarcinoma HepatocellularCell SurvivalRadical polymerizationIntraperitoneal injectionL-aspartamideMice NudeAntineoplastic AgentsEnhanced permeability and retention effect010402 general chemistryPolymethacrylic AcidsIn vivoCell Line TumormedicineAnimalsHumansneoplasmsProtein Kinase InhibitorsPhenylurea Compoundstechnology industry and agriculturedigestive system diseasesIn vitro0104 chemical sciencesDrug LiberationTumor targetingDelayed-Action PreparationsBiophysicsα-Poly(N-2-hydroxyethyl)-DNanoparticlesα-Poly(N-2-hydroxyethyl)-DL-aspartamidePeptidesJournal of controlled release : official journal of the Controlled Release Society
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π-Stacked polymers in drug delivery applications

2016

Abstract Polybenzofulvenes are π-stacked polymers, which can be synthesized by spontaneous polymerization of the corresponding monomers without the use of catalysts or initiators. Therefore, they can be obtained completely free from byproducts, impurities, or harmful substances. The absence of any relevant toxic effects and cell viability impairments allows PEGylated polybenzofulvene brushes to be potentially functional in a wide range of biological, biomedical, and biotechnological applications. Moreover, the properties of these polymers, in terms of interaction with pharmacological active agents and the ability to self-assemble into nanoaggregates or a quite compact physical gel useful as…

3003Materials sciencePharmaceutical ScienceNanotechnology02 engineering and technology010402 general chemistry01 natural scienceschemistry.chemical_compoundSide chainOrganic chemistrychemistry.chemical_classificationPolymer brusheClick chemistryPolymerPegylation021001 nanoscience & nanotechnologySmall molecule0104 chemical sciencesMonomerchemistryPolymerizationDrug deliveryDrug deliveryClick chemistryPEGylationPolybenzofulvene0210 nano-technology
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Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…

2017

Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…

3003Staphylococcus aureuslcsh:Medical technologyBiocompatibilitylcsh:Biotechnologyharmful to the environmentBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)Overall; ZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compounds; harmful to the environment; Bioengineering; Medicine (miscellaneous); Molecular Medicine; Biomedical Engineering; Applied Microbiology and Biotechnology; 3003Biocompatible MaterialsBioengineeringNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesApplied Microbiology and BiotechnologyNanomaterialsExtracellular polymeric substancelcsh:TP248.13-248.65HumansZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compoundNanotubesbiologyChemistryResearchBiofilm021001 nanoscience & nanotechnologybiology.organism_classificationAntimicrobialAnti-Bacterial Agents0104 chemical scienceslcsh:R855-855.5NanotoxicologyBiofilmsPseudomonas aeruginosaZNGs; biodeterioration; antimicrobial nanomaterialMolecular MedicineGraphiteNanorodOverallZinc Oxide0210 nano-technologyBacteria
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STEP 3: Restart Target DB2

2011

Finally, we RESTART TARGET DB2 and it's stopped databases.

33 Ciències TecnológiquesMathematicsofComputing_NUMERICALANALYSISInformationSystems_DATABASEMANAGEMENTComputingMethodologies_GENERAL
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The role of the tidal and wind forces on the hydrodynamic flow pattern in the Augusta Harbour (Italy)

2012

3D numerical modelingwindHydrodynamicSettore ICAR/01 - Idraulica
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On the Computational Error in 3D Simulation of Cutting

2009

3D numerical simulationSettore ING-IND/16 - Tecnologie E Sistemi Di Lavorazionemetal cutting
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EXTERNAL RECIRCULATION IN PRS TYPE TURBINE: EXPERIMENTAL AND NUMERICAL RESULTS.

2022

Cavitation is a relevant phenomenon for structural safety and noise level in hydraulic turbines, occurring when water pressure falls below the vapor value at a given temperature. In this case bubbles of vapor grow inside the liquid and move along with it. When the pressure returns above the vapor value the bubble collapses, and the pressure can locally achieve very high values, up to 7000 bars (Kumar & Saini, 2010). Moreover, if the bubble was confined also by the solid wall of a blade, the solid particles suspended in the fluid can be transported by the fluid ones and hit the solid wall at very high velocity, generating erosion. Cavitation is also the source of high frequency noise, ve…

3D simulations of a PRS type turbine identify low pressure zones inside the runner.3D Numerical simulations of the modified device confirm the sought after improvement.Experimental measures on a 5 kW prototype also confirm the sought after improvement.External recirculation of a small flux provides the required pressure increment in the target area.Settore ICAR/01 - Idraulica
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Better numerical approximation by Durrmeyer type operators

2018

The main object of this paper is to construct new Durrmeyer type operators which have better features than the classical one. Some results concerning the rate of convergence and asymptotic formulas of the new operator are given. Finally, the theoretical results are analyzed by numerical examples.

41A25 41A36Applied Mathematics010102 general mathematicsConstruct (python library)Numerical Analysis (math.NA)Type (model theory)Object (computer science)01 natural sciences010101 applied mathematicsMathematics (miscellaneous)Operator (computer programming)Rate of convergenceNumerical approximationFOS: MathematicsApplied mathematicsMathematics - Numerical Analysis0101 mathematicsMathematics
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Estimates for the differences of positive linear operators and their derivatives

2019

The present paper deals with the estimate of the differences of certain positive linear operators and their derivatives. Oxur approach involves operators defined on bounded intervals, as Bernstein operators, Kantorovich operators, genuine Bernstein-Durrmeyer operators, and Durrmeyer operators with Jacobi weights. The estimates in quantitative form are given in terms of the first modulus of continuity. In order to analyze the theoretical results in the last section, we consider some numerical examples.

41A25 41A36Applied MathematicsNumerical analysisLinear operatorsNumerical Analysis (math.NA)010103 numerical & computational mathematics01 natural sciencesModulus of continuity010101 applied mathematicsSection (fiber bundle)Mathematics - Classical Analysis and ODEsBounded functionTheory of computationClassical Analysis and ODEs (math.CA)FOS: MathematicsOrder (group theory)Applied mathematicsMathematics - Numerical Analysis0101 mathematicsAlgebra over a fieldMathematics
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Better approximation of functions by genuine Bernstein-Durrmeyer type operators

2018

The main object of this paper is to construct a new genuine Bernstein-Durrmeyer type operators which have better features than the classical one. Some direct estimates for the modified genuine Bernstein-Durrmeyer operator by means of the first and second modulus of continuity are given. An asymptotic formula for the new operator is proved. Finally, some numerical examples with illustrative graphics have been added to validate the theoretical results and also compare the rate of convergence.

41A25 41A36FOS: MathematicsNumerical Analysis (math.NA)Mathematics - Numerical Analysis
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