Search results for "Mesh"

Parallel Genetic Solution for Multiobjective MDO

1997

Publisher Summary This chapter reviews a multiobjective, multidisciplinary design optimization of two-dimensional airfoil designs. The control points on leading and trailing edges remain fixed, and the y-coordinates of the other control points are allowed to change during the optimization process. The grid for the Euler solver depends continuously and smoothly on the design parameters. The number of nodes and elements in the mesh might vary according to design because the meshes for the Helmholtz solver are done using the local fitting. The computations are made on an IBM SP2 parallel computer using high-performance switch and the MPICH message-passing library. As gradients are not required…

Efficient Time Integration of Maxwell's Equations with Generalized Finite Differences

2015

We consider the computationally efficient time integration of Maxwell’s equations using discrete exterior calculus (DEC) as the computational framework. With the theory of DEC, we associate the degrees of freedom of the electric and magnetic fields with primal and dual mesh structures, respectively. We concentrate on mesh constructions that imitate the geometry of the close packing in crystal lattices that is typical of elemental metals and intermetallic compounds. This class of computational grids has not been used previously in electromagnetics. For the simulation of wave propagation driven by time-harmonic source terms, we provide an optimized Hodge operator and a novel time discretizati…

Variants of human CLDN9 cause mild to profound hearing loss

2021

Hereditary deafness is clinically and genetically heterogeneous. We investigated deafness segregating as a recessive trait in two families. Audiological examinations revealed an asymmetric mild to profound hearing loss with childhood or adolescent onset. Exome sequencing of probands identified a homozygous c.475G>A;p.(Glu159Lys) variant of CLDN9 (NM_020982.4) in one family and a homozygous c.370_372dupATC;p.(Ile124dup) CLDN9 variant in an affected individual of a second family. Claudin 9 (CLDN9) is an integral membrane protein and constituent of epithelial bicellular tight junctions that form semi-permeable, paracellular barriers between inner ear perilymphatic and endolymphatic compartment…

Dynamic Analysis of Piezoelectric Structures by the Displacement Boundary Method

2009

Rapid and sensitive detection of metapneumovirus in clinical specimens by indirect fluorescence assay using a monoclonal antibody.

2008

Human metapneumovirus, with two known genotypes named A and B, is associated with mild respiratory symptoms to severe LRTI in children, high-risk adults and the elderly. Rapid and reliable methods of hMPV detection in clinical samples are essential to implement appropriate care, to better understand the pathology of hMPV and to determine its epidemiology. Respiratory samples from 1,386 patients collected during 2 consecutive years were screened for hMPV using indirect immunofluorescence (IFA) assay with a monoclonal antibody. Forty-three patients tested positive for hMPV by the IFA method. In parallel, the samples were examined with RT-PCR on the F gene. Of these, 41 specimens were RT-PCR p…