Search results for "Meta-"
showing 10 items of 1069 documents
The diagnostic accuracy of PIK3CA mutations by circulating tumor DNA in breast cancer: an individual patient data meta-analysis
2022
Background: The circulating tumor DNA (ctDNA) diagnostic accuracy for detecting phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA) mutations in breast cancer (BC) is under discussion. We aimed to compare plasma and tissue PIK3CA alterations, encompassing factors that could affect the results. Methods: Two reviewers selected studies from different databases until December 2020. We considered BC patients with matched tumor tissue and plasma ctDNA. We performed meta-regression and subgroup analyses to explore sources of heterogeneity concerning tumor burden, diagnostic technique, sample size, sampling time, biological subtype, and hotspot mutation. Pooled sensitiv…
Green value and spatial approaches of energy demand management.
2020
Les contraintes économiques et environnementales actuelles impliquent un besoin de maîtrise de la demande d’énergie du secteur résidentiel. Pour parvenir à cette fin, il est nécessaire d’identifier les déterminants de la consommation d’énergie des ménages puis de trouver des solutions pour réduire la demande d’énergie. Les travaux présentés dans la thèse portent sur le rôle des choix de localisation des ménages dans la formation de la demande d’énergie du secteur résidentiel et s’intéresse à la valeur verte comme outil de promotion des biens immobiliers énergétiquement efficaces. Le premier chapitre étudie les choix de localisation résidentielle et de consommation énergétique des ménages da…
Employment effects of reducing labour costs : considering potential bias in macro-estimates of the elasticity of labour demand
2017
In 2016 the Finnish government decided to implement the competitiveness pact in order to increase employment. The objective is to improve cost-competitiveness by lowering labor costs in the private sector. The elasticity of labour demand plays a key role in assessing the employment effects of the competitiveness pact. The idea of this study is based on the Economic Policy Council Report (2016) which argued that the government’s elasticity estimate is very high and predicts overly optimistic employment effects. The majority of studies estimate demand elasticities using aggregate data, which is likely to produce biased estimates. The problems relate in particular to the lack of exogenous vari…
Exercise treatment effect modifiers in persistent low back pain : an individual participant data meta-analysis of 3514 participants from 27 randomise…
2020
Background: Low back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise. Methods: In parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison character…
Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis
2022
Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or slow atherogenesis by decreasing excessive weight in the early stages of atherogenesis, by suppressing low-grade systemic inflammation as well as by inhibiting oxidative stress and endothelial dysfunction. The aim of this meta-analysis was to provide an answer to whether bariatric surgery has a significant effect on intima-media thickness (IMT) which is a surrogate marker of early atherosclerosis and has a good correlation with atherosclerotic coronary heart disease. Methods:…
Preoperative oral practices and incidence of postoperative complications in hospital medical-surgical procedures: A meta-analysis
2023
Oral decay prior to a hospital medical-surgical procedure is a risk factor for the development of postoperative complications. However, perioperative oral practices as a protective factor have not been studied. This review aims to evaluate the effectiveness of perioperative oral practices in the reduction of risk of developing postoperative complications in in-hospital medical surgical procedures. This review and meta-analysis was conducted according to Cochrane guidelines. Medline, Scopus, Scielo, and Cochrane were consulted. Articles of the previous 10 years concerning adult patients undergoing perioperative oral practices prior to hospital medical-surgical procedures, were included. Dat…
Basic Empathy Scale: A Systematic Review and Reliability Generalization Meta-Analysis
2022
The Basic Empathy Scale (BES) has been internationally used to measure empathy. A systematic review including 74 articles that implement the instrument since its development in 2006 was carried out. Moreover, an evidence validity analysis and a reliability generalization meta-analysis were performed to examine if the scale presented the appropriate values to justify its application. Results from the systematic review showed that the use of the BES is increasing, although the research areas in which it is being implemented are currently being broadened. The validity analyses indicated that both the type of factor analysis and reliability are reported in validation studies much more than the …
Physical activity reduces the risk of pneumonia : systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants
2022
The beneficial effects of regular physical activity in promoting health and preventing chronic diseases are well documented. The relationship between regular physical activity and the risk of pneumonia is uncertain. We aimed to evaluate the magnitude and specificity of the prospective association between regular physical activity and the risk of pneumonia using a systematic review and meta-analysis of published observational cohort studies in general populations. Relevant studies with at least 1 year of follow-up were sought from inception until 15 September 2021 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Relative risks (RRs) with 95% confidence intervals (C…
Enseignements d'une meta-analyse sur le lien participation budgétaire - performance managériale
2009
This meta-analysis is a critical comparison of three of quantitative synthesis. It applies some propositions of the Potsdam international consultation on meta-analysis, in the field of management control. Study design. After a traditional narrative review, three meta-analysis methodologies for the synthesis of articles with heterogeneous methodologies and fields are presented. After a short critical presentation of our results with “box score” and p-values combination methods, we show the result of best-evidence synthesis and its stability as recommended at the Potsdam international consultation on meta-analysis. Results. The results of methods of meta-analysis implemented do not make it po…