Search results for "Meta-"
showing 10 items of 1069 documents
Effect of Omega-3 Dosage on Cardiovascular Outcomes : An Updated Meta-Analysis and Meta-Regression of Interventional Trials
2021
Objectives:To quantify the effect of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids oncardiovascular disease (CVD) prevention and the effect of dosage. Methods:This study is designed as a random effects meta-analysis and meta-regression of ran-domized control trials with EPA/DHA supplementation. This is an update and expanded analysis ofa previously published meta-analysis which covers all randomized control trials with EPA/DHAinterventions and cardiovascular outcomes published before August 2019. The outcomes includedare myocardial infarction (MI), coronary heart disease (CHD) events, CVDevents (a composite ofMI, angina, stroke, heart failure, peripheral arterial disease, sudden de…
El libro no ha muerto: Desventaja meta-cognitiva de la lectura en pantalla
2018
A pesar de la rápida expansión de los dispositivos digitales como medio de lectura, el formato impreso sigue siendo el preferido por la mayoría de los lectores. Más aún, investigaciones recientes revelan cierta desventaja del medio digital cuando se trata de comprender textos. En el presente artículo se revisan una serie de trabajos realizados por la investigadora Rakefet Ackerman y sus colaboradores, cuyos resultados sugieren que esta inferioridad de la lectura en pantalla es consecuencia de déficits en la regulación meta-cognitiva cuando nos enfrentamos mediante el medio digital a tareas que exigen decisiones acerca de la asignación de esfuerzos cognitivos.
On automatic algorithm configuration of vehicle routing problem solvers
2019
Many of the algorithms for solving vehicle routing problems expose parameters that strongly influence the quality of obtained solutions and the performance of the algorithm. Finding good values for these parameters is a tedious task that requires experimentation and experience. Therefore, methods that automate the process of algorithm configuration have received growing attention. In this paper, we present a comprehensive study to critically evaluate and compare the capabilities and suitability of seven state-of-the-art methods in configuring vehicle routing metaheuristics. The configuration target is the solution quality of eight metaheuristics solving two vehicle routing problem variants.…
Liquid biopsy in colorectal carcinoma: the search for potential prognostic and predictive biomarkers
Background: Liquid biopsy is considered a repeatable, non-invasive and dynamic tool. It could be able to recover from liquid samples (expecially blood)) cancer-specific informations (miRNAs, circulating-free DNA (cfDNA), circulating tumor DNA (ctDNA) and exosomes) by overcoming the limitations associated with traditional tissue biopsy. Aim: to investigate the potential prognostic and predictive role of blood cancer-related biomarkers such as cfDNA or ctDNA and exosomal DNA in colorectal cancer (CRC) patients. Results: cfDNA or ctDNA and exosomal DNA could have a potential applicability in CRC management. New generation technologies are able to identify clinically relevant genomic alteration…
Fysioterapian vaikuttavuus ja merkityksellisyys aivoverenkiertohäiriötä ja multippeliskleroosia sairastaville kuntoutujille : järjestelmälliset kirja…
2022
Tutkimuksen tavoitteena oli selvittää fysioterapian vaikuttavuutta ja merkityksellisyyttä aivoverenkiertohäiriötä (AVH) ja multippeliskleroosia (MS) sairastavilla kuntoutujilla keskittyen erityisesti ICF:n suoritukset ja osallistuminen -osa-alueeseen. Vaikuttavuutta koskevat määrälliset kirjallisuuskatsaukset (vaihteluväli: AVH 1/2008–5/2017; MS 1/2007–1/2017) kohdistuivat satunnaistettuihin kontrolloituihin terapeuttisen harjoittelun tutkimuksiin (RCT) painottuen tasapainoon ja kävelyyn. Laadulliset kirjallisuuskatsaukset fysioterapian merkityksellisyydestä (1/2000–11/2017) kohdistuivat kuntoutujan kokemuksiin ja käsityksiin fysioterapiasta. Kahdeksassa osajulkaisussa oli yhteensä 182 RCT-…
Meta-analysis of the relationship between teachers’ self-efficacy and attitudes toward inclusive education
2022
This meta-study aims to examine the size of the relationship between teachers' self-efficacy and attitudes toward inclusive education of K-12 students with special educational needs and to identify potential moderators (publication, sample, and research procedure characteristics). We synthesized the research conducted from 1994 to 2018, and 41 studies were included. Bare-bones meta-analysis with random effect model revealed a sample size weighted correlation coefficient between teachers’ self-efficacy and attitudes as r¯ = 0.35 (CI = 0.31-0.39). The between-study variations were not associated with hypothesized publication and sample characteristics. However, the self-efficacy measurement m…
Network meta-analysis of randomized trials in multiple myeloma: Efficacy and safety in frontline therapy for patients not eligible for transplant
2022
The treatment scenario for newly-diagnosed transplant-ineligible multiple myeloma patients (NEMM) is quickly evolving. Currently, combinations of proteasome inhibitors (PI) and/or immunomodulatory drugs (IMiD) +/- the monoclonal antibody Daratumumab are used for first-line treatment, even if head-to-head comparisons are lacking. To compare efficacy and safety of these regimens, we performed a network meta-analysis (NMA) of 27 phase 2/3 randomized trials including a total of 12935 patients and 23 different schedules. Four efficacy/outcome and one safety indicators were extracted and integrated to obtain (for each treatment) the surface under the cumulative ranking-curve (SUCRA), a metric use…
Effects of Coenzyme Q10 on Statin-Induced Myopathy
2015
Abstract Objective To evaluate the efficacy of coenzyme Q10 (CoQ10) supplementation on statin-induced myopathy. Participants and Methods We searched the MEDLINE, Cochrane Library, Scopus, and EMBASE databases (November 1, 1987, to May 1, 2014) to identify randomized controlled trials investigating the impact of CoQ10 on muscle pain and plasma creatine kinase (CK) activity as 2 measures of statin-induced myalgia. Two independent reviewers extracted data on study characteristics, methods, and outcomes. Results We included 6 studies with 302 patients receiving statin therapy: 5 studies with 226 participants evaluated the effect of CoQ10 supplementation on plasma CK activity, and 5 studies (4 u…
Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 pa…
2014
article i nfo Introduction: VitaminD (vitD)deficiencymay beassociatedwith anincreased riskof statin-related symptomatic myalgia in statin-treated patients. The aim of this meta-analysis was to substantiate the role of serum vitamin D levels in statin-associated myalgia. Methods: The search included PUBMED, Cochrane Library, Scopus, and EMBASE from January 1, 1987 to April 1, 2014 to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Quantita- tive data synthesis was performed using a fixed-effect model. Results: The electronic search yielde…
Abstract 18967: Analysis of Vitamin D Levels in Patients With and Without Statin-induced Myalgia - A Systematic Review and Meta-analysis of 7 Studies…
2014
Introduction: Vitamin D (vit D) deficiency may be associated with an increased risk of statin-related muscle complaints, and symptomatic myalgia in statin-treated patients. Hypothesis: The aim of this meta-analysis was to investigate whether subjects with statin-induced myalgia have lower serum vit D levels compared with those who are asymptomatic. Methods: We searched PubMed, Web of Science, Cochrane Library, Scopus and EMBASE (up to March 2014) to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Results: The electronic search yielded 4…