Search results for "Meta-Analysis as Topic"

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

2017

In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is…

[Clinical equipoise and systematic reviews of randomized controlled trials].

2015

.Para poder valorar la validez de un ensayo cli´nico es necesarioque su disen˜o, ejecucio´n y ana´lisis se describan con suficientedetalle, exactitudytransparencia.Sinembargo,existennumerososejemplos en la literatura cienti´fica que ponen de manifiesto co´mola informacio´n facilitada en las publicaciones es muchas vecesdeficiente, y que con frecuencia se presentan problemas metodo-lo´gicos graves

Perioperative hyperoxia: Myths and realities

2017

New evidence in one-lung ventilation

2017

Mechanical ventilation in thoracic surgery has undergone significant changes in recent years due to the implementation of the protective ventilation. This review will analyze recent ventilatory strategies in one-lung ventilation. A MEDLINE research was performed using Mesh term "One-Lung Ventilation" including randomized clinical trials, metanalysis, reviews and systematic reviews published in the last 6 years. Search was performed on 21st March 2017. A total of 75 articles were initially found. After title and abstract review 14 articles were included. Protective ventilation is not simply synonymous of low tidal volume ventilation, but it also includes routine use of PEEP and alveolar recr…

El tabaquismo pasivo en adultos

2002

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

2011

Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology.

2013

The aims of severe perioperative bleeding management are three-fold. First, preoperative identification by anamesis and laboratory testing of those patients for whom the perioperative bleeding risk may be increased. Second, implementation of strategies for correcting preoperative anaemia and stabilisation of the macro- and microcirculations in order to optimise the patient's tolerance to bleeding. Third, targeted procoagulant interventions to reduce the amount of bleeding, morbidity, mortality and costs. The purpose of these guidelines is to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Eu…

Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

2017

[Background] The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.

Misguided Effort with Elusive Implications

2016

Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental p…

Comparison of Studies on Mobile Phone Use and Risk of Tumors

2010

published results of ameta-analysis of studies on mobile phone use and risk of tumors. Intheir analysis, the authors included 23 case-control studies, covering abroad spectrum of tumor entities including uveal melanoma, testicu-lar cancer, parotid gland tumors, and brain tumors.However, the authors give no rationale for pooling these hetero-geneous, biologically rather diverse cancer sites, for which the local-ized exposure from the use of mobile phones is completely different.The key difference between this particular meta-analysis com-pared with earlier ones is the use of a quality score. The use of qualityscoreshasbeenreportedtobea“formofsubjectivitymasqueradingasobjectivity”andithasbeen…