Search results for "Metabolic risk"
showing 5 items of 65 documents
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
2021
Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and…
Consenso español de salud física del paciente con depresión
2014
Comorbidity between depression and physical illnesses is very common and has a significant impact on the health and management of the patient. With the support of the Sociedades Espanolas de Psiquiatria y Psiquiatria Biologica, and Sociedad Espanola de Medicos de Atencion Primaria (SEMERGEN) a consensus was prepared on physical health in patients with depression and is summarized in the present work. The literature review highlighted the high frequency of cardiovascular and endocrine-metabolic disorders in patients with depression such as diabetes and obesity, thus making the primary and secondary prevention recommendations for patients with cardiovascular or metabolic risk applicable to pa…
Impact of Glucose-Lowering Medications on Cardiometabolic Risk in Type 2 Diabetes
2019
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Contributing pathophysiologic factors include endothelial dysfunction caused by excessive production of reactive oxygen species (ROS), increased activity of nuclear factor kB (NFkB), altered macrophage polarization, and reduced synthesis of endothelial progenitor cells (EPC). Consequently, there can be a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque, leading to increased cardiovascular mortality. Management is aimed at prevention, early diagnosis, and treatment of hyperglycemia and vascular complications. Innovative therape…
Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease
2020
The field of nutrition in early life, as an effective tool to prevent and treat chronic diseases, has attracted a large amount of interest over recent years. The vital roles of food products and nutrients on the body’s molecular mechanisms have been demonstrated. The knowledge of the mechanisms and the possibility of controlling them via what we eat has opened up the field of precision nutrition, which aims to set dietary strategies in order to improve health with the greatest effectiveness. However, this objective is achieved only if the genetic profile of individuals and their living conditions are also considered. The relevance of this topic is strengthened considering the importance of …
Uni ja kardiometabolia : vaihdevuosi-ikäisten naisten unen laadun yhteys sokeri- ja rasva-aineenvaihduntaan ja leptiinitasoihin
2017
Unen laatu heikkenee vaihdevuosien aikana. Heikentynyt unen laatu on yhteydessä sokeri- ja rasva-aineenvaihdunnan häiriöihin. Tämän pro gradu-tutkielman tarkoituksena oli selvittää vaihdevuosi-ikäisten naisten unen laadun yhteyttä kardiometabolisiin riskitekijöihin. Tutkielma perustuu Estrogeeni, vaihdevuodet ja toimintakyky (ERMA) -tutkimuksen aineistoon. Osallistujat poimittiin satunnaisotannalla väestörekisteristä Jyväskylän ja sen lähikuntien 47–54 -vuotiaista naisista (n=6886). Mukaan valittiin ne sisäänottokriteerit täyttävät naiset, jotka vastasivat tutkimuksen alkumittauskyselyyn ja joilta terveydentilaa selvittävän haastattelun sekä laboratoriomittausten jälkeen saatiin luotettavas…