Search results for "Metas"

PHENOTYPIC PROFILING OF OSTEOTROPIC BREAST CANCER CELLS

2015

One of the preferred locations of metastases from breast cancer is the bone tissue. On the other hand, it should be recalled that mammary tumors with equal clinical diagnosis have a different course, and also different metastatic progression. Therefore, it would be helpful to have appropriate markers of osteotropism to test on the surgical cancer tissues, in order to predict the possible propensity of the breast cancer to generate bone metastases and to adequate the therapeutic plan. We previously reported1,2 on the setting-up of an in vitro model for the study of the osteotropic propensity of breast cancer cells and the influences exerted by the bone microenvironment on the cancer cells ph…

ASSESSMENT OF BRAIN METASTASES VOLUME CONTROL DURING STEREOTACTIC RADIOSURGERY BY LONGITUDINAL REGION GROWTH MR IMAGE SEGMENTATION ANALYSIS

2015

Fe-rich Dunite Xenoliths from South African Kimberlites: Cumulates from Karoo Flood Basalts

2007

Fe-rich dunite xenoliths within the Kimberley kimberlites comprise olivine neoblasts with minor elongated, parallel-oriented ilmenite, and rarely olivine porphyroclasts and spinel. Compared with typical mantle peridotites, olivines in the Fe-rich dunites have lower forsterite (Fo87^89) and NiOcontents (1300^2800 ppm), which precludes a restitic origin for the dunites. Chrome-rich spinels are remnants of a metasomatic reaction that produced ilmenite and phlogopite.Trace element compositions differ between porphyroclastic and neoblastic olivine, the latter having higherTi, V, Cr and Ni and lower Zn, Zr and Nb contents, documenting their different origins.The dunites have high Os/Os ratios (0 …

Evidence of magmatic activity related to Middle Jurassic and Lower Cretaceous rifting from northeastern Brazil (Ceará-Mirim): K/Ar age, palaeomagneti…

1992

The Mesozoic magmatic activity in the easternmost part of NE Brazil (Ceara-Mirim) is mainly represented by two-pyroxene tholeiitic dykes; only few dykes have alkaline character. K/Ar ages and palaeomagnetism data indicate that Ceara-Mirim dykes are of Middle Jurassic (175-160 Ma) and Early Cretaceous (140-130 Ma) age. Both Middle Jurassic and Lower Cretaceous dykes have high incompatible-element concentrations and TiO2 with the lower contents generally confined to the Middle Jurassic dykes; rare tholeiitic dykes low in TiO2 and incompatible elements are present. Sr/1bNd isotopic and other chemical data do not support appreciable crustal contamination and in a 87Sr86Sr vs. 143Nd144Nd diagram…

Halogens in Mafic and Intermediate-Silica Content Magmas

2018

As volatile and variably mobile components, halogens play key roles in magmatic, metasomatic, mineralizing, and volcanic processes by influencing the physical and chemical properties of melts, fluids, and minerals. Volcanic emission of halogens to the atmosphere leads to long- and short-term impacts on atmospheric chemistry that range from global perturbation of the stratospheric O3 budget to more localized life-threatening contamination of soils and fresh water. The concentrations of F, Cl, Br, and I in melts, fluids, and minerals provide crucial geochemical information and insights into magmatic processes ranging from partial melting to volcanic eruptions. Halogen research is useful for e…

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

2012

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family and has diverse roles. NGAL can stabilize matrix metalloproteinase-9 from autodegradation. NGAL is considered as a siderocalin that is important in the transport of iron. NGAL expression has also been associated with certain neoplasias and is implicated in the metastasis of breast cancer. In a previous study, we examined whether ectopic NGAL expression would alter the sensitivity of breast epithelial, breast and colorectal cancer cells to the effects of the chemotherapeutic drug doxorubicin. While abundant NGAL expression was detected in all the cells infected with a retrovirus encoding NGAL, t…

GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutra…

2021

Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between KRas and GSK-3. To further elucidate the roles of GSK-3β in drug-resistance, we transfected KRas-dependent MIA-PaCa-2 pancreatic cells with wild-type (WT) and kinase-dead (KD) forms of GSK-3β. Transfection of MIA-PaCa-2 cells with WT-GSK-3β increased their resistance to various chemotherapeutic drugs and certain small molecule inhibitors. Transfection of cells with KD-GSK-3β often increased therapeutic sensitivity. An exception was observed wi…

Computation of Unstable Binodals Not Requiring Concentration Derivatives of the Gibbs Energy

1998

The equilibrium of three liquid phases in a binary mixture implies the existence of tie lines and binodals that are different from the normal experimentally observable ones. First of all, there are the metastable extensions of the binodal built up by S/S tie lines. These S/S tie lines fulfill the equilibrium condition of the minimum of the Gibbs energy of the entire two-phase system. Both coexisting phases are located within the meta(stable) region. There are two additional types of tie lines:  U/U (maximum of the Gibbs energy; both end points within the unstable area) and U/S tie lines (saddle point; one end point within the (meta)stable, the other within the unstable region). All types of…

Liquid-vapour phase behaviour of a symmetrical binary fluid mixture

1998

Using Monte-Carlo simulation and mean field calculations, we study the liquid-vapour phase diagram of a square well binary fluid mixture as a function of a parameter $\delta$ measuring the relative strength of interactions between particles of dissimilar and similar species. The results reveal a rich variety of liquid-vapour coexistence behaviour as $\delta$ is tuned. Specifically, we uncover critical end point behaviour, a triple point involving a vapour and two liquids of different density, and tricritical behaviour. For a certain range of $\delta$, the mean field calculations also predict a `hidden' (metastable) liquid-vapour binodal.

Demixing time and temperature influence on porosity and interconnection of PLLA scaffolds prepared via TIPS

2009

Scaffolds suitable for tissue engineering applications were prepared by Thermally Induced Phase Separation (TIPS) starting from a ternary solution PLLA/ dioxane/water. The experimental protocol consisted of three consecutive steps, a first quench from the homogeneous solution to an appropriate demixing temperature (within the binodal region), a liquid-liquid demixing stage for a given time and a final quench from the demixing temperature to a low temperature (within the spinodal region). A large variety of morphologies, in terms of average pore size and interconnection were obtained upon modifying the demixing time and temperature, owing to the interplay of nucleation and growth processes d…