Search results for "Metas"

2021

Bone is a frequent site of metastases, being typically associated with a short-term prognosis in affected patients. Photodynamic therapy (PDT) emerges as a promising alternative treatment for controlling malignant disease that can directly target interstitial metastatic lesions. The aim of this study was to assess the effect induced by PDT treatment on both primary (giant cell bone tumor) and human bone metastatic cancer cell lines (derived from a primary invasive ductal breast carcinoma and renal carcinoma). After 24 h post light delivery (blue light-wavelength 436 nm) with 5-aminolevulinic acid, the effect on cellular migration, viability, apoptosis, and senescence were assessed. Our resu…

A very short uranium-uranium bond: The predicted metastable U22+

2005

Quantum chemical calculations, based on multiconfigurational wave functions and including relativistic effects, show that the U(2)2+ system has a large number of low-lying electronic states with S of 0 to 2 and Lambda ranging from zero to ten. These states share a very small bond length of about 2.30 A, compared to 2.43 A in neutral U2. The Coulomb explosion to 2 U+ lowers the energy by only 1.6 eV and is separated by a broad barrier.

Genetic and epigenetic alterations as hallmarks of the intricate road to cancer.

2003

Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progression springs from the combined forces of both genetic and epigenetic events, which produce variant clonal populations, together with the selective pressures of the microenvironment, which promote growth and, perhaps, dissemination of variants with a specific set of characteristics. Although the importance of genetic mutations in cancer has long been recognized, the role of epigenetic events has been suggested more recently. This review focuses on the genetic and epigenetic molecular mechanisms involved in cancer onset and progression, and discusses the possibility of new strategies in the de…

Cancer stem cells – old concepts, new insights

2008

Cancer has long been viewed as an exclusively genetic disorder. The model of carcinogenesis, postulated by Nowell and Vogelstein, describes the formation of a tumor by the sequential accumulation of mutations in oncogenes and tumor suppressor genes. In this model, tumors are thought to consist of a heterogeneous population of cells that continue to acquire new mutations, resulting in a highly dynamic process, with clones that out compete others due to increased proliferative or survival capacity. However, novel insights in cancer stem cell research suggest another layer of complexity in the process of malignant transformation and preservation. It has been reported that only a small fraction…

Biological consequences of tumor hypoxia

2001

Growing evidence from experimental and clinical studies points to the fundamental, pathophysiologic role of hypoxia in solid tumors. Intratumoral hypoxia is a consequence of a structurally and functionally disturbed microcirculation, with deterioration of the diffusion geometry and of tumor-associated anemia. Hypoxia-induced changes of the proteome in the neoplastic and stroma cells may lead to neoplastic growth impairment through molecular mechanisms, resulting in cellular quiescence, differentiation, and apoptosis. Alternatively, hypoxia-induced proteome changes activating nonspecific stress response, anaerobic metabolism, angiogenesis, tissue remodeling, and change of cell contacts may p…

Rare earth elements in apatite as a monitor of magmatic and metasomatic processes: The Ilímaussaq complex, South Greenland

2015

Abstract Textural and compositional variations of apatite from the plutonic Ilimaussaq complex in South Greenland and its surrounding country rocks track magmatic and metasomatic processes. Detailed back-scattered electron (BSE) imaging reveals various types of apatite textures including (i) growth zonation (concentric, oscillatory as well as sector zonation) formed during magmatic differentiation, (ii) resorption and overgrowth textures due to fluid/melt induced metasomatic overprint of precursor apatite and (iii) replacement textures indicating the destabilization of apatite in favor of monazite. In the least evolved rocks of the Ilimaussaq complex, apatite incorporates rare earth element…

Constraints on mantle source and interactions from He-Sr isotope variation in Italian Plio-Quaternary volcanism

2008

[1] Helium isotope ratios of olivine and pyroxene phenocrysts from Plio-Quaternary volcanic rocks from southern Italy (seven Aeolian Islands, Mt. Vulture, Etna, Ustica, and Pantelleria) range from 2.3 to 7.1 Ra. Importantly, the phenocryst 3He/4He correlate well with whole rock Sr isotopic composition (0.70309–0.70711), reflecting the mixing of two sources. A significant contribution of He from crustal contamination is recorded only occasionally (e.g., pyroxenes from Vulcano). When merged with data from the Roman Comagmatic Province, a remarkably strong near-linear He-Sr isotope correlation is apparent. The general northward decrease in 3He/4He corresponds to an increase in 87Sr/86Sr (and a…

Factors that influence treatment delay in patients with colorectal cancer

2016

// Irene Zarcos-Pedrinaci 1, 11 , Alberto Fernandez-Lopez 2 , Teresa Tellez 1, 11 , Francisco Rivas-Ruiz 1, 11 , Antonio Rueda A 3, 11 , Maria Manuela Morales Suarez-Varela 4 , Eduardo Briones 5 , Marisa Bare 6, 11 , Antonio Escobar 7, 11 , Cristina Sarasqueta 8, 11 , Nerea Fernandez de Larrea 9, 11 , Urko Aguirre 10, 11 , Jose Maria Quintana 10, 11 , Maximino Redondo 1, 11 and On Behalf of the CARESS-CCR Study Group 1 Research Unit, Agencia Sanitaria Costa del Sol, Marbella, Spain 2 Servicio de Cirugia, Agencia Sanitaria Costa del Sol, Marbella, Spain 3 Servicio de Oncologia Medica, Agencia Sanitaria Costa del Sol, Marbella, Spain 4 Unit of Public Health, Hygiene and Environmental Health, …

Melanoma Clinics and Treatment

2013

Treatment of esophageal cancer in inoperable elderly patients: our experience

2009

The esophagus carcinoma has an incidence rate of 3–4 new cases per 100,000 inhabitants, per year, with a male/female ratio of 3:1 and with a low incidence between the VI–VII decade of life. In Italy, the incidence rate equals 2,000 new cases/year with a mortality rate of 3–5/100,000 inhabitants.