Search results for "Metas"

Noise Induced Phenomena in point Josephson junctions

2008

We present the analysis of the mean switching time and its standard deviation of short overdamped Josephson junctions, driven by a direct current and a periodic signal. The effect of noise enhanced stability is investigated. It is shown that fluctuations may both decrease and increase the switching time.

2012

classical and quantum systems are investigated. First, the role of multiplicative and additive noise in a classical metastable system is analyzed. The mean lifetime of the metastable state shows a nonmonotonic behavior with a maximum as a function of both the additive and multiplicative noise intensities. In the second system, the simultaneous action of thermal and non-Gaussian noise on the dynamics of an overdamped point Josephson junction is studied. The eect of a Levy noise generated by a Cauchy‐Lorentz distribution on the mean lifetime of the superconductive metastable state, in the presence of a periodic driving, is investigated. We find resonant activation and noise enhanced stability…

Voltage drop across Josephson junctions for L\'evy noise detection

2020

We propose to characterize L\'evy-distributed stochastic fluctuations through the measurement of the average voltage drop across a current-biased Josephson junction. We show that the noise induced switching process in the Josephson washboard potential can be exploited to reveal and characterize L\'evy fluctuations, also if embedded in a thermal noisy background. The measurement of the average voltage drop as a function of the noise intensity allows to infer the value of the stability index that characterizes L\'evy-distributed fluctuations. An analytical estimate of the average velocity in the case of a L\'evy-driven escape process from a metastable state well agrees with the numerical calc…

Enhancement of stability in systems with metastable states

2007

The investigation of noise‐induced phenomena in far from equilibrium systems is one of the approach used to understand the behaviour of physical and biological complex systems. Metastability is a generic feature of many nonlinear systems, and the problem of the lifetime of metastable states involves fundamental aspects of nonequilibrium statistical mechanics. The enhancement of the life‐time of metastable states through the noise enhanced stability effect and the role played by the resonant activation phenomenon will be discussed in models of interdisciplinary physics: (i) Ising model (ii) Josephson junction; (iii) stochastic FitzHugh‐Nagumo model; (iv) a population dynamics model, and (v) …

Noise stabilization effects in models of interdisciplinary physics

2009

Metastability is a generic feature of many nonlinear systems, and the problem of the lifetime of metastable states involves fundamental aspects of nonequilibrium statistical mechanics. The investigation of noise-induced phenomena in far from equilibrium systems is one of the approaches used to understand the behaviour of physical and biological complex systems. The enhancement of the lifetime of metastable states through the noise enhanced stability effect and the role played by the resonant activation phenomenon will be discussed in models of interdisciplinary physics: (i) polymer translocation dynamics; (ii) transient regime of FitzHugh-Nagumo model; (iii) market stability in a nonlinear …

Nonlinear relaxation phenomena in metastable condensed matter systems

2016

Nonlinear relaxation phenomena in three different systems of condensed matter are investigated. (i) First, the phase dynamics in Josephson junctions is analyzed. Specifically, a superconductor-graphene-superconductor (SGS) system exhibits quantum metastable states, and the average escape time from these metastable states in the presence of Gaussian and correlated fluctuations is calculated, accounting for variations in the the noise source intensity and the bias frequency. Moreover, the transient dynamics of a long-overlap Josephson junction (JJ) subject to thermal fluctuations and non-Gaussian noise sources is investigated. Noise induced phenomena are observed, such as the noise enhanced s…

Stabilization Effects of Dichotomous Noise on the Lifetime of theSuperconducting State in a Long Josephson Junction

2015

We investigate the superconducting lifetime of a long overdamped current-biased Josephson junction, in the presence of telegraph noise sources. The analysis is performed by randomly choosing the initial condition for the noise source. However, in order to investigate how the initial value of the dichotomous noise affects the phase dynamics, we extend our analysis using two different fixed initial values for the source of random fluctuations. In our study, the phase dynamics of the Josephson junction is analyzed as a function of the noise signal intensity, for different values of the parameters of the system and external driving currents. We find that the mean lifetime of the superconductive…

Phase dynamics in graphene-based Josephson junctions in the presence of thermal and correlated fluctuations

2014

In this work we study by numerical methods the phase dynamics in ballistic graphene-based short Josephson junctions. The supercurrent through a graphene junction shows a non-sinusoidal phase-dependence, unlike a conventional junction ruled by the well-known d.c. Josephson relation. A superconductor-graphene-superconductor system exhibits superconductive quantum metastable states similar to those present in normal current-biased JJs. We explore the effects of thermal and correlated fluctuations on the escape time from these metastable states, when the system is stimulated by an oscillating bias current. As a first step, the analysis is carried out in the presence of an external Gaussian whit…

Plasma cell-free DNA in diagnostic KRAS mutation testing

2015

Epidermaalisen kasvutekijän reseptorin (EGFR) monoklonaalisia vasta-aineita (mAb) käytetään apuna metastaattisen kolorektaalisyövän (mCRC) hoidossa. Aktivoivat mutaatiot KRAS- ja NRAS-onkogeeneissä tekevät syöpäsolut vastustuskykyisiksi anti-EGFR-vasta-aineille, ja tästä syystä tuumorit tulee genotyypittää ennen hoidon aloittamista. Kudosbiopsian ottaminen on kuitenkin invasiivinen toimenpide, eikä näyte välttämättä edusta kattavasti syövän kaikkien solupopulaatioiden geneettisiä muutoksia. Verenkierron solunulkoisen DNA:n (cfDNA) on havaittu sisältävän maligneista soluista lähtöisin olevia onkogeenisiä mutaatioita, ja se voi olla hyvä vaihtoehtoinen tuumoriperäisen DNA:n lähde. Kehitimme j…

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

2020

Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tiss…