Search results for "Method"
showing 10 items of 13253 documents
Quantitative Vibrational Spectrometry in the 21st Century: A Scientometric Evaluation
2005
Abstract The state of the art of research on vibrational spectrometry–based quantitative methodologies was evaluated from the literature compiled in Analytical Abstracts from 1980. Medium and near infrared, Raman spectrometry, and photoacoustic methods of analysis were considered. The evolution of the number of published papers, the distribution of the literature as a function of the different application fields in which the vibrational methods were employed, and a study of the impact on this area of chemometric and automation studies clearly shows that, from the 1990s until now, the importance of vibrational spectrometry in application analysis has grown to reach maturity. This field provi…
Adopting magnetocaloric heat pumping and refrigeration for electrical vehicle
2017
International audience; Refrigeration process is based on conventional gas compression and expansion techniques. However, this technique has numerous disadvantages since it generates greenhouse gas and is partly responsible for global warming. This paper exposes analternative method: magnetocaloric refrigeration that presents the advantage to combine high-energy efficiency and respect of theenvironment. Magnetic heat pumping and cooling is compared to conventional method applied on vehicle air conditioning system.Simulation results are used to demonstrate the approach.
Efficient Addition of Acid Enediolates to Epoxides
2004
We report new conditions to facilitate the addition of dianions of carboxylic acids to epoxides as an alternative method to the use of aluminum enolates. These conditions require the use of a sub-stoichiometric (10%) amount of amine for dianion generation and the previous activation of the epoxide with LiCl. Other Lewis acids have been shown to be less effective. Yields are good but only low diastereoselectivity is attained, which has not been controlled despite attempts at optimization. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Detection of Cancer Stem Cells Using AC133 Antibody
2012
The cancer stem cell (CSC) model postulates that tumors are formed and maintained by a small population of undifferentiated cells, characterized by unique self-renewal properties and malignant potential. As CSCs survive chemotherapy inducing tumor recurrence, the specific targeting and eradication of these cells represents an important therapeutic challenge in cancer cure. Recent findings on CD133, a pentaspan transmembrane glycoprotein, discuss its application in the identification and isolation of SCs from cancerous tissues. However, the appropriateness of this protein constitutes an ongoing discussion. The expression pattern is debated and several issues highlight the need for additional…
Erythrocytes labeled with [18F]SFB as an alternative to radioactive CO for quantification of blood volume with PET
2013
Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and research applications. However, owing to the short half-life of the radiolabeled CO, it can only be used in centers equipped with a cyclotron. In the present work, we propose an alternative method to label the red blood cells with [(18) F] in order to obtain blood volume measurements by PET. The use of the radioactive synthon [(18) F] N-succinimidyl 4-[(18) F]fluorobenzoate ([(18) F]SFB) was evaluated for erythrocyte labeling and PET blood volume imaging. The images provided by [(18) F]SFB labeled eryth…
Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Res…
2019
Introduction: The GEM-CESAR trial is a potentially curative strategy for high-risk smoldering multiple myeloma (HRsMM) patients in which the primary endpoint is the assessment of bone marrow minimal residual disease negativity by next generation flow (NGF). However, alternative methods of tumor burden evaluation in serum, like Quantitative Immunoprecipitation Mass Spectrometry (QIP-MS), a polyclonal antibody-based technology to identify intact immunoglobulins, have been also evaluated. Patients and Methods: Ninety HRsMM patients included in the GEM-CESAR trial received six 4-weeks cycles of carfilzomib, lenalidomide and dexamethasone followed by high dose melphalan and ASCT and 2 further cy…
Co-precipitation synthesis of Nd:YAG nano-powders: the effect of Nd dopant addition with thermal treatment
2007
Nanopowders of Yttrium Aluminium Garnet doped with neodymium ions were obtained by the co-precipitation method from the reaction of aluminium, yttrium and neodymium nitrate with ammonia. The amount of neodymium was selected in order to produce samples of nominal stoichiometry NdXY (3-X)Al5O12 (where X = 0.006, 0.012, 0.024, 0.048, 0.081, 0.096, 0.17, 0.19, 0.38, 0.54, and 0.72, respectively). After washing and drying, the hydroxide precursors were subjected to Thermo-Gravimetry and Differential Thermal Analysis experiments from room temperature up to 1500 °C, which showed the presence of exothermal events accompanying phase transformation phenomena. X-ray diffraction investigations conducte…
Italian Amateur Pop-Rock Musicians on Facebook: Mixed Methods and New Findings in Music Making Research
2017
This chapter investigates how and why amateur musicians use social networking sites, employing a mixed-methods approach. Attention is focused on four big Italian Facebook communities of pop-rock musicians: drums, bass, guitar, and keyboard players (overall, 2,101 active users), analyzing the relational and textual data extracted from the web. The chapter analyzes the network structures emerging from the interactions among the users. It also identifies and maps the main areas of discussion (sound shaping, studio recording, marketplace, musical references, computer production, and relations) and the latent semantic dimension characterizing Facebook users’ activities, through social network an…
Reduction of Dinitrogen to Ammonia in Irradiated Heterogeneous Systems
1988
The recent developments of the research in the field of dinitrogen reduction to ammonia at mild conditions of pressure and temperature are reported. After a brief historical recapitulation of the traditional thermal process, the new routes for NH3 synthesis (biological photosynthesis, direct electrochemical reduction, and photocatalytic reduction) are presented and critically discussed. A particular attention is devoted to heterogeneous photocatalytic reduction performed by irradiating pure, mixed, and doped semiconducting catalysts in gas-solid and liquid-solid systems. The fixation of dinitrogen in aqueous solutions containing complexes and photoactive particulate systems is also reported…
The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease
2020
Abstract Alzheimer’s disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer’s disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer’s disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the a…