Search results for "Methodology"
showing 10 items of 852 documents
The Geometry of Uniqueness, Sparsity and Clustering in Penalized Estimation
2021
We provide a necessary and sufficient condition for the uniqueness of penalized least-squares estimators whose penalty term is given by a norm with a polytope unit ball, covering a wide range of methods including SLOPE, PACS, fused, clustered and classical LASSO as well as the related method of basis pursuit. We consider a strong type of uniqueness that is relevant for statistical problems. The uniqueness condition is geometric and involves how the row span of the design matrix intersects the faces of the dual norm unit ball, which for SLOPE is given by the signed permutahedron. Further considerations based this condition also allow to derive results on sparsity and clustering features. In …
CUDASW++ 3.0: accelerating Smith-Waterman protein database search by coupling CPU and GPU SIMD instructions
2013
Background The maximal sensitivity for local alignments makes the Smith-Waterman algorithm a popular choice for protein sequence database search based on pairwise alignment. However, the algorithm is compute-intensive due to a quadratic time complexity. Corresponding runtimes are further compounded by the rapid growth of sequence databases. Results We present CUDASW++ 3.0, a fast Smith-Waterman protein database search algorithm, which couples CPU and GPU SIMD instructions and carries out concurrent CPU and GPU computations. For the CPU computation, this algorithm employs SSE-based vector execution units as accelerators. For the GPU computation, we have investigated for the first time a GPU …
Applying Support Vector Machines for Gene Ontology based gene function prediction.
2004
Abstract Background The current progress in sequencing projects calls for rapid, reliable and accurate function assignments of gene products. A variety of methods has been designed to annotate sequences on a large scale. However, these methods can either only be applied for specific subsets, or their results are not formalised, or they do not provide precise confidence estimates for their predictions. Results We have developed a large-scale annotation system that tackles all of these shortcomings. In our approach, annotation was provided through Gene Ontology terms by applying multiple Support Vector Machines (SVM) for the classification of correct and false predictions. The general perform…
HECTOR : a parallel multistage homopolymer spectrum based error corrector for 454 sequencing data
2014
Background Current-generation sequencing technologies are able to produce low-cost, high-throughput reads. However, the produced reads are imperfect and may contain various sequencing errors. Although many error correction methods have been developed in recent years, none explicitly targets homopolymer-length errors in the 454 sequencing reads. Results We present HECTOR, a parallel multistage homopolymer spectrum based error corrector for 454 sequencing data. In this algorithm, for the first time we have investigated a novel homopolymer spectrum based approach to handle homopolymer insertions or deletions, which are the dominant sequencing errors in 454 pyrosequencing reads. We have evaluat…
Metodo e testualità. Costruzioni analtiche e modi di fare
2022
This number of E | C has an experimental character. The contributions gathered in the volume collect the fruit of the work of a cycle of seminars that took place in Palermo between October and December 2021: they were entitled "Text analysis seminars" and saw the participation of Giuditta Bassano, Denis Bertrand , Alice Giannitrapani, Manar Hammad, Tarcisio Lancioni, Dario Mangano, Francesco Mangiapane, Gianfranco Marrone, Maria Pia Pozzato, Carlo Andrea Tassinari and Ilaria Ventura Bordenca. The seminars were intended to reflect on the semiotic method, already the subject of the 2017 conference of the Italian Association of Semiotic Studies, whose proceedings were published in the numbers …
How does and should one compare law?
2017
The essay critically analyzes two papers from two comparative public law scholars to infer a wider comparative view to their approach.
Effect of oligonucleotide primers in determining viral variability within hosts
2004
Abstract Background Genetic variability in viral populations is usually estimated by means of polymerase chain reaction (PCR) based methods in which the relative abundance of each amplicon is assumed to be proportional to the frequency of the corresponding template in the initial sample. Although bias in template-to-product ratios has been described before, its relevance in describing viral genetic variability at the intrapatient level has not been fully assessed yet. Results To investigate the role of oligonucleotide design in estimating viral variability within hosts, genetic diversity in hepatitis C virus (HCV) populations from eight infected patients was characterised by two parallel PC…
The University of Opole and Biblical and Semitic Rhetoric
2017
The goal of this presentation is not to perform scientific research but to present the group of students, who form the Student’s Research Group of Theology at Universitas Opoliensis in Poland. The aim of the group is the study of Biblical and Semitic Rhetoric and its popularization in the country. The object of the work of these young scholars is entwined with three Learning Seminars and the International Conference of the RBS in Rome. In Poland they have become known by organizing in schools educational workshops «The Lord’s Prayer & Menorah». Their particular methodology of cooperative work is based on human values such as mutual listening and dialogue. Listening is not understood in its …
La metodologia della ricerca in didattica
2021
Il testo descrive le tipologie di ricerca in campo didattico; segnala le aree più rappresentate nel panorama italiano degli ultimi anni e gli ambiti ritenuti prioritari per i prossimi anni; indica una metodologia capace di migliorare la pratica educativa già durante lo svolgimento delle azioni di ricerca; fornisce dei suggerimenti per assicurare la qualità delle ricerche di Didattica indipendentemente dal metodo di indagine adoperato. Le argomentazioni svolte sono animate dalla profonda convinzione che non sia possibile fare ricerca in Didattica senza la collaborazione e il confronto dei ricercatori universitari con gli insegnanti e con gli educatori in generale. The text describes the type…
La utilització de WebQuest i de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats
2010
Aquest treball té com objectiu estudiar la importància d'implantar metodologies docents centrades en les noves tecnologies de la informació i comunicació (TIC), amb la finalitat de potenciar la participació de l'estudiant i de millorar els seus resultats d'aprenentatge. Concretament,aprofundirem en el disseny d'una WebQuest i en l'ús de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats. Els resultats obtinguts serviran de base per a dissenyar les guies i metodologies docents de les assignatures de l'àrea de Comercialització i Investigació de Mercats en els nous estudis de grau.