Search results for "Methylprednisolone"

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Methylprednisolone-induced hepatotoxicity in a 16-year-old girl with multiple sclerosis.

2018

Multiple sclerosis (MS) is a chronic inflammatory disease with demyelination of the central nervous system. High-dosage corticosteroids are the first-line therapy in the acute relapsing of MS. We report a case of severe high-dose methylprednisolone-induced acute hepatitis in a patient with a new diagnosis of MS. A 16-year-old girl was admitted for urticaria, angioedema, nausea and vomiting a month later she had been diagnosed with MS and treated with high-dosage methylprednisolone. Laboratory investigations showed hepatic insufficiency with grossly elevated liver enzymes. A liver biopsy showed focal centrilobular hepatocyte necrosis with interface hepatitis. Methylprednisolone-induced hepat…

paediatrics (drugs And Medicines)safetymedicine.medical_specialtyMultiple SclerosisAdolescentNauseaAnti-Inflammatory AgentsGastroenterologyMethylprednisoloneDiagnosis Differential03 medical and health sciencesLiver disease0302 clinical medicineInternal medicinemedicineHumansunwanted effects/adverse reactionsGlucocorticoidsmedicine.diagnostic_testAngioedemabusiness.industryMultiple sclerosisGeneral Medicinemedicine.diseaseMethylprednisolonePulse Therapy DrugLiver biopsyVomitingSettore MED/26 - Neurologia030211 gastroenterology & hepatologyFemaleDifferential diagnosismedicine.symptomChemical and Drug Induced Liver Injuryliver diseasebusiness030217 neurology & neurosurgerymedicine.drugFindings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse EffectBMJ case reports
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