Search results for "Mg"
showing 10 items of 492 documents
Feature Extraction and Selection for Pain Recognition Using Peripheral Physiological Signals.
2019
In pattern recognition, the selection of appropriate features is paramount to both the performance and the robustness of the system. Over-reliance on machine learning-based feature selection methods can, therefore, be problematic; especially when conducted using small snapshots of data. The results of these methods, if adopted without proper interpretation, can lead to sub-optimal system design or worse, the abandonment of otherwise viable and important features. In this work, a deep exploration of pain-based emotion classification was conducted to better understand differences in the results of the related literature. In total, 155 different time domain and frequency domain features were e…
''Investigating reduction of dimensionality during single-joint elbow movements: a case study on muscle synergies''
2013
Chiovetto, Enrico | Berret, Bastien | Delis, Ioannis | Panzeri, Stefano | Pozzo, Thierry; International audience; ''A long standing hypothesis in the neuroscience community is that the central nervous system (CNS) generates the muscle activities to accomplish movements by combining a relatively small number of stereotyped patterns of muscle activations, often referred to as" muscle synergies." Different definitions of synergies have been given in the literature. The most well-known are those of synchronous, time-varying and temporal muscle synergies. Each one of them is based on a different mathematical model used to factor some EMG array recordings collected during the execution of variety…
First principles simulations of 2D Cu superlattices on the MgO(0 0 1) surface
2004
AbstractFirst principles slab simulations of copper 2D superlattices of different densities on the perfect MgO(001) surface are performed using the DFT method as implemented into the CRYSTAL98 computer code. In order to clarify the nature of interfacial bonding, we consider regular 1/4, 1/2 and 1 monolayer (ML) coverages and compare results of our calculations with various experimental and theoretical data. Our general conclusion is that the physical adhesion associated with a Cu polarization and charge redistribution gives the predominant contribution to the bonding of the regular Cu 2D layer on the MgO(001) surface.
High mobility group box 1 and markers of oxidative stress in human cord blood.
2019
Background Parturition induces considerable oxidative stress and many inflammatory mediators, such as high mobility group box 1 (HMGB1), are involved from the beginning of the pregnancy to birth. The aim of the present study was to evaluate serum cord blood concentration of diacron-reactive oxygen metabolites (d-ROM), biological antioxidant potential (BAP), and HMGB1 to investigate the perinatal oxidative status of neonates and correlation with mode of delivery, as well as the influence of labor. Methods The subjects consisted of 214 neonates delivered at University Hospital "G. Martino", Messina, in a 6 months period. Venous blood samples were collected from the umbilical cord after cord s…
Usage des points massiques et des courbes de Bézier pour la modélisation des cubiques
2017
International audience; Cet article étend l'étude des points singuliers et des points d'inflexion des courbes rationnelles cubiques en s'ins-pirant de la méthode proposée par M. Sakai dans le cadre des points massiques. L'intérêt des points massiques est de généraliser le tracé des courbes admettant des points doubles et de contrôler sans calcul supplémentaire l'en-semble des fonctions algébriques cubiques. Un exemple d'application est la réalisation de lettre à l'anglaise ou lettre manuscrite. Les courbes de Bézier permettent d'approcher des profils complexes, le travail présenté permet d'aborder de la même manière l'ensemble des courbes, ce que ne permet pas les splines cubiques d'Hermite.
Points massiques, cubiques Bézier rationnelles et leur points singuliers
2018
National audience; Cet articleétend l'étude des points singuliers des courbes rationnelles cubiques. Ellle porte sur les points d'inflexion, les points doubles et points de rebroussement. Les courbes cubiques rationnelleś etudiées sont décrites au moyen de la technique des points massiques. Un point massique est soit un point pondéré soit un vecteur pur. Il prend le statut de point de contrôle pour une représentation pa-ramétrique exploitable sur ordinateur dans le domaine de la géométrie de la Conception Assistée par Ordinateur. L'intérêt des points massiques est de pouvoir généraliser le tracé des courbes admettant des points doubles et de contrôler sans calcul supplémentaire l'ensemble d…
DNA binding of L1 is required for human papillomavirus morphogenesis in vivo.
2002
AbstractThe role of putative DNA-binding domains of human papillomavirus (HPV) capsid proteins for DNA encapsidation in vivo is still unknown. We have now analyzed mutants of the major capsid protein L1 of HPV type 33, which are defective for DNA binding, for their ability to encapsidate DNA using an in vivo packaging approach. Since the DNA-binding domain and the nuclear localization signal (NLS) of L1 overlap, both a carboxy-terminal deletion mutant (L1-1/470) and a substitution mutant (L1-1/477M9) were analyzed. L1-1/477M9 has the classical NLS replaced by a noncanonical NLS taken from the human hnRNP protein A1. The mutant proteins were defective for DNA binding in contrast to wild-type…
Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions
2010
How DNA repair machineries detect and access, within the context of chromatin, lesions inducing little or no distortion of the DNA structure is a poorly understood process. Removal of oxidized bases is initiated by a DNA glycosylase that recognises and excises the damaged base, initiating the base excision repair (BER) pathway. We show that upon induction of 8-oxoguanine, a mutagenic product of guanine oxidation, the mammalian 8-oxoguanine DNA glycosylase OGG1 is recruited together with other proteins involved in BER to euchromatin regions rich in RNA and RNA polymerase II and completely excluded from heterochromatin. The underlying mechanism does not require direct interaction of the prote…
Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents
2011
HMG-CoA reductase inhibitors (statins) are widely used in the therapy of hypercholesterolemia. Apart from their lipid-lowering activity, they have pleiotropic effects that are attributed to the inhibition of regulatory proteins, including Ras-homologous (Rho) GTPases. Here, we discuss the potential usefulness of statins to prevent normal tissue damage provoked by radiotherapy. Statins reduce the mRNA expression of pro-inflammatory and pro-fibrotic cytokines stimulated by ionizing radiation in vitro and alleviate IR-induced inflammation and fibrosis in vivo. The currently available data indicate that statins accelerate the rapid repair of DNA double-strand breaks and, moreover, mitigate the …
Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide
2006
Background and purpose: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are frequently used lipid-lowering drugs. Moreover, they exert pleiotropic effects on cellular stress responses and death. Here, we analysed whether lovastatin affects the sensitivity of primary human endothelial cells (HUVEC) to the anticancer drug doxorubicin. Experimental approach: We investigated whether pretreatment of HUVEC with low dose of lovastatin influences the cellular sensitivity to doxorubicin. To this end, cell viability, proliferation and apoptosis as well as DNA damage-triggered stress response were analysed. Key results: Lovastatin reduced the cytotoxic potency of doxorub…