Search results for "Mg"
showing 10 items of 492 documents
Komplicētas žultsakmeņu slimības iznākumi pēc endoskopiskās retrogrādās holangiopankreatogrāfijas
2019
Endoskopiskā retrogrādā holangiopankreatogrāfija (ERHP) ir visjutīgākā un efektīvākā diagnostikas un ārstēšanas metode pankreatobiliārās sistēmas slimībām. Tomēr kā jebkura invazīva procedūra, ERHP var radīt nopietnas komplikācijas, kuras var būt saistītas ar pašas procedūras tehniku vai tās laikā pielietoto sedāciju. Kā piemēru var minēt ar pašu procedūru saistītās - post-ERHP pankreatītu un asiņošanu. Holedoholitiāzes gadījumā ERHP ir būtiska ārstēšanas metode. Darba hipotēze bija - pacientiem ar holedoholitiāzi bez citām žultsakmeņu slimības komplikācijām hospitalizācijas dienu skaits ir mazāks un ERHP komplikāciju risks zemāks. Pētījuma mērķis bija salīdzināt ar ERHP saistītu komplikāci…
Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor
2000
AbstractCholesterol entering cells in low-density lipoproteins (LDL) via receptor-mediated endocytosis is transported to organelles of the late endocytic pathway for degradation of the lipoprotein particles. The fate of the free cholesterol released remains poorly understood, however. Recent observations suggest that late-endosomal cholesterol sequestration is regulated by the dynamics of lysobisphosphatidic acid (LBPA)-rich membranes [1]. Genetic studies have pinpointed a protein, Niemann–Pick C-1 (NPC-1), that is required for the mobilization of late-endosomal/lysosomal cholesterol by an unknown mechanism [2]. Here, we report the removal of accumulated cholesterol by overexpression of the…
Binding of [3H][D-Ala2, MePhe4, Gly-ol5] Enkephalin, [3H][D-Pen2, D-Pen5]Enkephalin, and [3H]U-69,593 to Airway and Pulmonary Tissues of Normal and S…
1997
Abstract Bhargava, H. N., V. M. Villar, J. Cortijo and E. J. Morcillo. Binding of [3H][D-Ala2, MePhe4, Gly-ol5]enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats. Peptides 18(10) 1603–1608, 1997.—The role of endogenous opioid peptides in the regulation of bronchomotor tone, as well as in the pathophysiology of asthma is uncertain. We have studied the binding of highly selective [3H]labeled ligands of μ-([D-Ala2, MePhe4, Gly-ol5]enkephalin; DAMGO), δ ([D-Pen2, D-Pen5]enkephalin; DPDPE), and κ-(U-69,593) opioid receptors to membranes of trachea, main bronchus, lung parenchyma and pulmonary artery obtained from normal (uns…
Comparing Surface and Fine-Wire Electromyography Activity of Lower Leg Muscles at Different Walking Speeds.
2019
Ankle plantar flexor muscles are active in the stance phase of walking to propel the body forward. Increasing walking speed requires increased plantar flexor excitation, frequently assessed using surface electromyography (EMG). Despite its popularity, validity of surface EMG applied on shank muscles is mostly unclear. Thus, we examined the agreement between surface and intramuscular EMG at a range of walking speeds. Ten participants walked overground at slow, preferred, fast, and maximum walking speeds (1.01 ± 0.13, 1.43 ± 0.19, 1.84 ± 0.23, and 2.20 ± 0.38 m s–1, respectively) while surface and fine-wire EMG activities of flexor hallucis longus (FHL), soleus (SOL), medial gastrocnemius (MG…
Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model
2022
Purpose We aimed to evaluate the near-final height (nFHt) in a large cohort of pediatricpatients with growth hormone deficiency (GHD) and to elaborate a new predictive method of nFHt. Methods We recruited GHD patients diagnosed between 1987 and 2014 and followed-up until nFHt. To predict the values of nFHt, each predictor was run in a univariable spline. Results We enrolled 1051 patients. Pre-treatment height was -2.43 SDS, lower than parental height (THt) (-1.09 SDS, p < 0.001). The dose of recombinant human GH (rhGH) was 0.21mg/kg/week at start of treatment. nFHt was -1.08 SDS (height gain 1.27 SDS), higher than pre-treatment height (p < 0.001) and comparable to THt. 1.6% of the pat…
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Er…
2011
In the present study we aimed to verify if the enhancement of glial cell line-derived neurotrophic factor (GDNF) production in mouse striatum following treatment with LY379268 may also induce in the nigrostriatal system a time-related activation of RET receptor and its specific intracellular signaling. For this purpose, we have investigated the effects of LY379268 treatment on RET phosphorylation at the Tyr1062 and on downstream signaling Erk1/2, Akt and PLCγ1 pathway activation. The results showed that treatment with LY379268 (3 mg/kg) induces a significant increase of GDNF levels and time-related RET and Erk1/2 phosphorylation in the striatum. These increases were detected at 24 h and 48 …
Topical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Mice
2017
Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a glycolipid fraction (MGDG) obtained from the microalga Isochrysis galbana on a TPA-induced epidermal hyperplasia murine model. In a first set of experiments, we examined the preventive effects of MGMG-A and MGDG dissolved in acetone on TPA-induced hyperplasia model in mice. In a second step, we performed…
Nelipistevyötuennan vaikutus ylävartalon lihasaktiivisuuteen, selkälihasten refleksivasteeseen ja lihasväsymykseen työkoneperäisessä tärinäaltistukse…
2013
Jylänki, Juha Petteri 2013. Nelipistevyötuennan vaikutus ylävartalon lihasaktiivisuuteen, selkälihasten refleksivasteeseen ja lihasväsymykseen työkoneperäisessä tärinäaltistuksessa. Liikuntabiologian laitos, Vuotech, Jyväskylän Yliopisto. Biomekaniikan pro gradu –tutkielma, 94 s. Tämän tutkimuksen tarkoituksena oli selvittää nelipistevyön tuennan merkitys pitkäkestoisessa (7x8 min) työkoneperäisessä tärinäaltistuksessa. Tuennan vaikutusta tutkittiin mittaamalla altistuksen aiheuttamaa lihasaktiivisuutta altistuksen aikana, sekä altistuksen jälkeistä lihasväsymystä. Tutkimuksessa pyrittiin hakemaan myös yhteyttä lihasaktiivisuuden ja koehenkilöiden kokeman subjektiivisen rasituksen välillä. …
Kurzemes un Zemgales hercogistes landtāgā skatīto jautājumu analīze (1682-1698)
2018
Pētījums veltīts maz pētītam jautājumam Latvijas vēsturē Kurzemes un Zemgales hercoga Frīdriha Kazimira valdīšanas laikam, jo 17. gadsimta nogales hercogistes vēstures pētniecība palikusi hercoga Jēkaba valdīšanas laika un 18. gadsimta sākuma cīņas par varu hercogistē ēnā. Pētījuma mērķis ir caur hercogistes landtāgu lēmumiem analizēt aktualitātes un problēmas laika periodā no 1682. gada līdz 1698. gadam. Pētījuma izstrādes laikā tika iegūta informācija par aktuāliem jautājumiem hercogistē saistībā ar baznīcu, zemnieku dzīves regulējumu, ekonomiku un tirdzniecību un ārpolitiku. Landtāgu lēmumu analīze atklāja būtisku visas hercogistes pastāvēšanas laika posma iezīmi – hercoga un muižniecība…
Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein
2011
GABARAPL1 belongs to the small family of GABARAP proteins (including GABARAP, GABARAPL1 and GABARAPL2/GATE-16), one of the two subfamilies of the yeast Atg8 orthologue. GABARAPL1 is involved in the intracellular transport of receptors, via an interaction with tubulin and GABA(A) or kappa opioid receptors, and also participates in autophagy and cell proliferation. In the present study, we identify the HSP90 protein as a novel interaction partner for GABARAPL1 using GST pull-down, mass spectrometry and coimmunoprecipitation experiments. GABARAPL1 and HSP90 partially colocalize in MCF-7 breast cancer cells overexpressed Dsred-GABARAPL1 and in rat brain. Moreover, treatment of MCF-7 cells overe…