Search results for "Michael"
showing 10 items of 171 documents
Aika-, yksilö- ja yhteiskuntakäsitykset suomalaisessa tulevaisuuspolitiikassa
2015
Organocatalytic approach to benzofused nitrogen-containing heterocycles: enantioselective total synthesis of (+)-angustureine.
2008
Nuevas metodologías en la reacción aza-Michael intramolecular organocatalítica
2022
La síntesis asimétrica es un área clave en la Química moderna, especialmente relevante en la industria farmacéutica dada la íntima relación entre la actividad biológica de las biomoléculas y su estereoquímica. Al mismo tiempo, la concienciación sobre la contaminación y los múltiples problemas que esta puede ocasionar, ha impulsado que estas metodologías sean más ecológicas y respetuosas con en el medio ambiente. En este sentido, la organocatálisis se ha revelado en los últimos años como una de las estrategias más interesantes para la obtención de compuestos enantioenriquecidos. En consecuencia, nuestro grupo de investigación se ha centrado en la aplicación de dicha estrategia a la reacción …
A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl-azoliums. A base catalysed C–C bond-formation step
2013
The NHC catalysed nucleophilic additions of enols to α,β-unsaturated acyl-azolium intermediates have been investigated using DFT methods at the MPWB1K/6-31G** computational level. In the direct and the conjugate additions, formation of a hydrogen bond (HB) with the carboxyl oxygen is not sufficient to favour the C-C bond formation as a consequence of the low nucleophilic character of enols. Interestingly, when enols form a HB with the chloride counterion, the activation energies associated with the conjugate addition decrease as a consequence of the increased nucleophilic character of enols and the increased electrophilic character of the 'acyl-azolium + Cl' ion pair. Analysis of the DFT re…
Michael Pollan: Toinen luonto
2019
Kirja-arvostelu teoksesta Michael Pollan: Toinen luonto, Puutarhurin oppivuodet. Niin&näin, 2018, Tapani Kilpeläinen ym. nonPeerReviewed
Michael Pollan: Tuntematon mieli
2021
Kirja-arvostelu teoksesta Michael Pollan: Tuntematon mieli, mitä uusi psykedeliatutkimus opettaa (How to Change Your Mind. What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence) suom. Mika Pekkola, Like -kustannus, 2021. nonPeerReviewed
Mukaiyama-Michael reactions with α-substituted acroleins - a useful tool for the synthesis of the pectenotoxins and other natural product targets
2013
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors
2012
Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…
Vapaus, valtio ja politiikka
2008
Englantilaisen politiikan filosofin Michael Oakeshottin (1901–1990) käsitys vapaudesta ja sen kehittyminen toisen maailmansodan jälkeisistä vuosista aina hänen pääteokseensa On Human Conduct (1975) saakka muodostaa tarinan, jota tässä artikkelissa seurataan. Näinä vuosina hänen tuotantonsa pääpaino oli poliittisessa ajattelussa, joten myös hänen vapauden käsityksensä on suhteutettava tähän. Vapautta voidaan pitää yhtenä politiikan teorian peruskäsitteistä – ideana tai kulmakivenä – ja näin ollen myös Oakeshottia on hyvä verrata aiempiin ja nykyisiin politiikan teorian perinteisiin. peerReviewed
Polystyrene-supported organocatalysts for alfa-selenenylation and Michael reactions. A common post-modification approach for catalytic differentiation
2011
Three different resin-supported catalysts have been prepared by using the well established post-modification approach by means of thiol-ene coupling reaction. Two catalysts were tested for the first time in the asymmetric α-selenenylation of propanal, while the third catalyst was used in the Michael addition reaction. While the preliminary results are not encouraging in the case of supported Jørgensen’ catalyst, interesting data have been collected with both for the supported MacMillan and prolyl-prolinol catalysts. In fact, these catalysts displayed good activity and selectivity. A reversed enantioselectivity in the α-selenenylation was observed by changing the polarity of the solvent. Fin…