Search results for "Micro"
showing 10 items of 23412 documents
Practical Strategies for Stable Operation of HFF-QCM in Continuous Air Flow
2013
Currently there are a few fields of application using quartz crystal microbalances (QCM). Because of environmental conditions and insufficient resolution of the microbalance, chemical sensing of volatile organic compounds in an open system was as yet not possible. In this study we present strategies on how to use 195 MHz fundamental quartz resonators for a mobile sensor platform to detect airborne analytes. Commonly the use of devices with a resonant frequency of about 10 MHz is standard. By increasing the frequency to 195 MHz the frequency shift increases by a factor of almost 400. Unfortunately, such kinds of quartz crystals tend to exhibit some challenges to obtain a reasonable signal-to…
Comparison of Microscopic Interacting Boson Model and Quasiparticle Random Phase Approximation 0νββ Decay Nuclear Matrix Elements
2021
The fundamental nature of the neutrino is presently a subject of great interest. A way to access the absolute mass scale and the fundamental nature of the neutrino is to utilize the atomic nuclei through their rare decays, the neutrinoless double beta (0νββ) decay in particular. The experimentally measurable observable is the half-life of the decay, which can be factorized to consist of phase space factor, axial vector coupling constant, nuclear matrix element, and function containing physics beyond the standard model. Thus reliable description of nuclear matrix element is of crucial importance in order to extract information governed by the function containing physics beyond the standard m…
Desarrollo y evaluación de metodologías de microextracción para el análisis de volúmenes pequeños de muestra
2022
El empleo de técnicas de microextracción ha permitido el desarrollo de métodos analíticos de elevada sensibilidad. Además, ha conseguido reducir el empleo de disolventes orgánicos y otros compuestos tóxicos, permitiendo así trabajar acorde con los principios de la denominada Química Analítica ‘Verde’ en general (Green Analytical Chemistry, GAC) y, en particular, en la etapa de preparación de la muestra (Green Sample Preparation, GSP). No obstante, la miniaturización de estas técnicas, en ocasiones, descuida la miniaturización del volumen de muestra, a pesar de las múltiples ventajas que esta aporta, como son la reducción, todavía mayor, de volúmenes de disolvente, cantidad de sorbente y de …
Desarrollo de metodologías sostenibles de análisis
2017
Uno de los retos actuales en la Química Analítica reside en el desarrollo de metodologías analíticas sostenibles que respeten los principios planteados por la Química Verde, de manera su impacto sobre el entorno sea mínimo. Para conseguir este objetivo se han establecido diferentes estrategias o líneas de investigación. En primer lugar, las técnicas de microextracción están aportando numerosas ventajas, aunque todavía presentan algunas limitaciones. Por consiguiente, resulta necesario desarrollar técnicas que automaticen la etapa relativa al pretratamiento de la muestra con el fin de disminuir tanto el tiempo de análisis como la manipulación de la muestra. En segundo lugar, y atendiendo a l…
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations
2020
Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…
La prevención de la rabia y la sanidad municipal en Valencia (1894-1916)
1998
Se estudia la introducción de la vacunación antirrábica en Valencia tras su descubrimiento por Pasteur en 1885. La investigación se ha realizado a partir de documentación de archivo y de prensa médica de la época. Su aplicación se enmarca dentro de la «medicina de laboratorio», mayoritariamente seguida por los integrantes del Cuerpo Municipal de Sanidad del Ayuntamiento valenciano y que permitió una estrecha relación con los laboratorios españoles y extranjeros situados en ese momento a la cabeza de la investigación bacteriológica.
Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.
2003
International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Applications of Microlocal Analysis in Inverse Problems
2020
This note reviews certain classical applications of microlocal analysis in inverse problems. The text is based on lecture notes for a postgraduate level minicourse on applications of microlocal analysis in inverse problems, given in Helsinki and Shanghai in June 2019.
Biological and Mechanical Characterization of the Random Positioning Machine (RPM) for Microgravity Simulations
2021
The rapid improvement of space technologies is leading to the continuous increase of space missions that will soon bring humans back to the Moon and, in the coming future, toward longer interplanetary missions such as the one to Mars. The idea of living in space is charming and fascinating; however, the space environment is a harsh place to host human life and exposes the crew to many physical challenges. The absence of gravity experienced in space affects many aspects of human biology and can be reproduced in vitro with the help of microgravity simulators. Simulated microgravity (s-μg) is applied in many fields of research, ranging from cell biology to physics, including cancer biology. In…