Search results for "Microbispora"

showing 4 items of 14 documents

Inorganic phosphate is a trigger factor for Microbispora sp. ATCC-PTA-5024 growth and NAI-107 production

2014

Background NAI-107, produced by the actinomycete Microbispora sp. ATCC-PTA-5024, is a promising lantibiotic active against Gram-positive bacteria and currently in late preclinical-phase. Lantibiotics (lanthionine-containing antibiotics) are ribosomally synthesized and post-translationally modified peptides (RiPPs), encoded by structural genes as precursor peptides. The biosynthesis of biologically active compounds is developmentally controlled and it depends upon a variety of environmental stimuli and conditions. Inorganic phosphate (Pi) usually negatively regulates biologically-active molecule production in Actinomycetes, while it has been reported to have a positive control on lantibiotic…

food.ingredientPhosphateBioengineeringBiologyApplied Microbiology and BiotechnologyPhosphatesMicrobiologychemistry.chemical_compoundfoodBacteriocinsBiosynthesisPolyphosphateHumansRibosomal Post-translationally modified Peptides (RiPPs)2. Zero hungerPhoP-PhoRResearchStructural geneBiological activityLantibioticsbiology.organism_classificationActinobacteriaRibosomal Post-translationally modified Peptides (RiPPs) Phosphate PhoP-PhoR PolyphosphateChemically defined mediumRegulonchemistryBiochemistryMicrobisporaBacteriaBiotechnology
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A proteomic investigation to explore biochemical capabilities of a lantibiotic producer Microbispora strain

2011

lantibioticMicrobisporaSettore BIO/19 - Microbiologia Generaleproteomic
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Having a look at Microbispora sp. ATCC-PTA-5024, a lantibiotic producer, "from the cradle to the grave" at the proteome level

2012

lantibioticproteomicsMicrobispora sp. ATCC‐PTA‐5024Settore BIO/19 - Microbiologia Generale
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Microbispora sp. ATCC-PTA-5024 proteomic analysis to study metabolic pathway changes before and during lantibiotic production

2011

proteomic analysiMicrobispora sp. ATCC-PTA-5024lantibiotic productionSettore BIO/19 - Microbiologia Generale
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