Search results for "Middle-aged"
showing 4 items of 14 documents
Clinical and Morphologic Predictors of Outcome in a Multicenter Cohort of ITP Patients Treated with Trombopoietin Analogues
2018
Abstract Background: The role of bone marrow response in patients with immune thrombocytopenia (ITP) has gained paramount importance since the last 10 years, with the demonstrations that marrow megakaryocytes (MGK) are unable to properly compensate platelets peripheral destruction. TPO receptor agonists (TPOa), namely romiplostim (ROMI) and eltrombopag (EPAG), by stimulating megakaryopoiesis are able to induce a response in 74% to 94% of cases in clinical trials. However, real world use of these drugs has shown frequent changes in individual dose requirement, the possibility of treatment discontinuation, and their effectiveness outside registered indications; moreover, nothing is known abou…
Female reproductive factors are associated with objectively measured physical activity in middle-aged women
2017
Physical activity improves health and may delay the onset of several chronic diseases. For women in particular, the rate of these diseases accelerates at middle age; therefore it is important to identify the determinants of health-enhancing physical activity during midlife in this population. In this study, we focused on determinants that are unique to the female sex, such as childbearing and menopause. The main objective was to characterize the level of physical activity and differences between active and inactive middle-aged Finnish women. In addition, we examined the association of physical activity with female reproductive factors at midlife. The study population consisted of 647 women …
Bem-estar psicológico em função da etapa de vida, sexo e sua interação
2016
Objetivo. Evaluar las diferencias en las dimensiones del bienestar psicológico en función de los grupos de edad, sexo y su interacción. Método. Se obtuvo una muestra de 706 participantes, dividida en tres grupos de edad (jóvenes, adultos y adultos mayores), quienes respondieron a las escalas de bienestar psicológico de Ryff. Se calculó un Manova teniendo en cuenta las variables grupo de edad, sexo y su interacción. Posteriormente, se realizaron varios Anova para conocer entre cuáles grupos existían diferencias para cada dimensión. Resultados. El análisis mostró una disminución, con la edad, en las dimensiones de bienestar psicológico de relaciones positivas con otros y crecimiento personal,…
Impact of using different levels of threshold-based artefact correction on the quantification of heart rate variability in three independent human co…
2020
Heart rate variability (HRV) is a non-invasive indicator of autonomic nervous system function. HRV recordings show artefacts due to technical and/or biological issues. The Kubios software is one of the most used software to process HRV recordings, offering different levels of threshold-based artefact correction (i.e., Kubios filters). The aim of the study was to analyze the impact of different Kubios filters on the quantification of HRV derived parameters from short-term recordings in three independent human cohorts. A total of 312 participants were included: 107 children with overweight/obesity (10.0 ±