Search results for "Mine"
showing 10 items of 20410 documents
Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
2019
Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could be a useful replacement for protamine, which is in current clinical use. However, micelles can have low stability in human serum and unacceptable toxicity profiles. This paper reports the optimi- sation of self-assembled multivalent (SAMul) arrays of amphiphilic ligands to bind heparin in competitive conditions. Specifically, modification of the hydrophobic unit kinetically stabilises the self-assembled nanostructures, preventing loss of binding ability in the presence of…
Automatic Profiling of Open-Ended Survey Data on Medical Workplace Teaching
2019
On-the-job medical training is known to be challenging due to the fast-paced environment and strong vocational profile. It relies on on-site supervisors, mainly doctors and nurses with long practical experience, who coach and teach their less experienced colleagues, such as residents and healthcare students. These supervisors receive pedagogical training to ensure that their guidance and teaching skills are constantly improved. The aim of such training is to develop participants’ patient, collegiate and student guidance skills in a multiprofessional environment, and to expand their understanding of guidance as part of their work as supervisors of healthcare professionals. In this paper, we …
Using Recorded Audio Feedback in Cross-Cultural e-Education Environments to Enhance Assessment Practices in a Higher Education
2018
Providing feedback to learners on their writing assignments is perhaps one of the most important and time-consuming tasks that a supervisor performs. In e-Education environments, giving feedback becomes more challenging because there are often no possibilities for face-to-face discussions with learners. Typically, a supervisor provides comments to learners in written form via email; however, the use of recorded audio feedback (RAF) in e-Education environments has become a viable alternative. The purpose of this case study was to examine learners’ perceptions of RAF and written feedback for their assignments at the University of Jyväskylä (Finland) and at Keio University SFC (Japan). Formati…
Barriers and facilitators of older people's mHealth usage: a qualitative review of older people's views
2018
The aim of this qualitative evidence synthesis is to identify and assess existing\ud evidence on barriers to and facilitators of older people’s usage of mHealth. Existing\ud literature identified many factors that affect people’s experiences and perceptions of\ud mHealth, which are in turn influenced by their personal circumstances and biography.\ud The following themes were identified using the thematic synthesis approach: (a)\ud perception of usefulness, (b) user requirements, (c) self-efficacy, (d) sense of self and\ud control, (e) privacy and confidentiality, and (f) cost. MHealth devices and services are\ud complex interventions that have to be integrated into an older person’s life in…
Specifications for carbonate content quantification in recent marine sediments using Rock-Eval pyrolysis
2019
11 pages; International audience; The amount of CaCO3 in sediments and/or sedimentary rocks is usually measured by calcimetry while the nature of the carbonates is determined by X-ray diffraction. Recently, a carbonate recognition method based on the results of Rock-Eval pyrolysis was proposed in 2014 by Pillot et al. [1]. Rock-Eval pyrolysis is also widely used for the characterization of recent sediments. However, later in 2015 Baudin et al. [2] noticed that some of the characteristics of recent sediments tended to produce different results from those of more classical Rock-Eval analyses, causing bias in interpretations.In this study, the thermal stability of fossil and recent marine carb…
Occurrence of antibiotics and antiretroviral drugs in source-separated urine, groundwater, surface water and wastewater in the peri-urban area of Chu…
2020
Recently, there has been an increased interest in bridging the knowledge gap in the occurrence and fate of pharmaceuticals in African urban water cycles. In this study, the occurrence of 7 antibiotics and 3 antiretrovirals in source-separated urine, groundwater, wastewater and surface water of the peri-urban area of Chunga in Lusaka, Zambia, was studied. In groundwater, the pharmaceuticals were only sporadically present with 4 antibiotics and 1 antiretroviral detected. The concentration of the antibiotics ranged from below limit of quantification (<LOQ) to 880 ng/L, with sulfamethoxazole having the highest detection frequency of 42.3%. In the surface water, a comparatively high concentrati…
Extreme minimal learning machine: Ridge regression with distance-based basis
2019
The extreme learning machine (ELM) and the minimal learning machine (MLM) are nonlinear and scalable machine learning techniques with a randomly generated basis. Both techniques start with a step in which a matrix of weights for the linear combination of the basis is recovered. In the MLM, the feature mapping in this step corresponds to distance calculations between the training data and a set of reference points, whereas in the ELM, a transformation using a radial or sigmoidal activation function is commonly used. Computation of the model output, for prediction or classification purposes, is straightforward with the ELM after the first step. In the original MLM, one needs to solve an addit…
Impact of accounting process characteristics on accounting outsourcing - Comparison of users and non-users of cloud-based accounting information syst…
2019
Article In Press The article of record as published may be found at https://doi.org/10.1016/j.accinf.2019.06.002 Prior literature informs us that a company's decision to outsource a business process depends on process characteristics such as how frequently the process is performed or how specific the assets required by the process are. In this article, we compare the effects of accounting process characteristics on outsourcing decisions across users of traditional and cloud-based accounting information systems (AIS). By focusing on outsourcing of accounting processes among small and medium sized enterprises, we investigate the effect of five business process characteristics (frequency, huma…
A survey on handling computationally expensive multiobjective optimization problems with evolutionary algorithms
2017
Evolutionary algorithms are widely used for solving multiobjective optimization problems but are often criticized because of a large number of function evaluations needed. Approximations, especially function approximations, also referred to as surrogates or metamodels are commonly used in the literature to reduce the computation time. This paper presents a survey of 45 different recent algorithms proposed in the literature between 2008 and 2016 to handle computationally expensive multiobjective optimization problems. Several algorithms are discussed based on what kind of an approximation such as problem, function or fitness approximation they use. Most emphasis is given to function approxim…
Do Randomized Algorithms Improve the Efficiency of Minimal Learning Machine?
2020
Minimal Learning Machine (MLM) is a recently popularized supervised learning method, which is composed of distance-regression and multilateration steps. The computational complexity of MLM is dominated by the solution of an ordinary least-squares problem. Several different solvers can be applied to the resulting linear problem. In this paper, a thorough comparison of possible and recently proposed, especially randomized, algorithms is carried out for this problem with a representative set of regression datasets. In addition, we compare MLM with shallow and deep feedforward neural network models and study the effects of the number of observations and the number of features with a special dat…