Search results for "Mining"
showing 10 items of 1730 documents
Distinctive Patterns of Intraclonal Diversification In IGHV1-2*04 Immunoglobulin Receptors of Patients with Splenic Marginal Zone Lymphoma: A of Ongo…
2011
Abstract Abstract 2638 We recently demonstrated that over 30% of cases with splenic marginal-zone lymphoma (SMZL) express distinctive immunoglobulin (IG) receptors that utilize a single polymorphic variant of the IGHV1-2 gene (IGHV1-2*04) and also exhibit restricted antigen-binding site motifs and precise targeting of somatic hypermutation (SHM). On these grounds, we proposed the existence of molecular subtypes of SMZL defined by immunogenetic analysis of the IG receptors with implications for selection by specific (super) antigenic element(s) in the development of at least a major subset of SMZL. In order to gain insight as to whether antigen involvement is relevant only prior to the malig…
Genetic Variability of Hepatitis C Virus before and after Combined Therapy of Interferon plus Ribavirin
2008
We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR binding domain and the V3 domain in the NS5A region. We used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation of therapy and after 6 or/and 12 months of treatment. A range of 25-100 clones per patient, genome region and time sample were sequenced. These were used to detect general patterns of adaptation, t…
MetaCache-GPU: Ultra-Fast Metagenomic Classification
2021
The cost of DNA sequencing has dropped exponentially over the past decade, making genomic data accessible to a growing number of scientists. In bioinformatics, localization of short DNA sequences (reads) within large genomic sequences is commonly facilitated by constructing index data structures which allow for efficient querying of substrings. Recent metagenomic classification pipelines annotate reads with taxonomic labels by analyzing their $k$-mer histograms with respect to a reference genome database. CPU-based index construction is often performed in a preprocessing phase due to the relatively high cost of building irregular data structures such as hash maps. However, the rapidly growi…
Analysing the presence of school-shooting related communities at social media sites
2010
Surprisingly cruel mass murders and attacks have been witnessed in the educational institutions of the Western world since the 1970s. These are often referred to as 'school shootings'. There have been over 300 known incidents around the world and the number is growing. Social network sites (SNSs) have enabled the perpetrators to express their views and intentions. Our result is that since about 2005, all major school shooters have had a presence in SNS and some have left traces that would have made possible to evaluate their intentions to carry out a rampage. A further hypothesis is that future school shooters will behave in a similar manner and would thus be traceable in the digital sphere…
Ecotoxicity assessment of boreal lake sediments affected by metal mining: Sediment quality triad approach complemented with metal bioavailability and…
2019
Highlights • Ecological risk assessment of metal-contaminated boreal lakes and sediments. • Sediment Quality Triad complemented with bioavailability and body residue studies. • Toxicity studies for natural sediments with several organisms and endpoints • Adverse effects observed. High variation on results between different methods. • Standard toxicity tests not suitable for testing, too low pH hampers the results. There are several methods for studying metal-contaminated freshwater sediments, but more information is needed on which methods to include in ecological risk assessment. In this study, we compliment the traditional Sediment Quality Triad (SQT) approach – including information on c…
Occurrence of coal and coal-derived particle-bound polycyclic aromatic hydrocarbons (PAHs) in a river floodplain soil.
2006
A PAH contaminated river floodplain soil was separated according to grain size and density. Coal and coal-derived particles from coal mining, coal industry and coal transportation activities were identified by organic petrographic analysis in our samples. Distinct concentrations of PAHs were found in different grain size and density fractions, however, similar distribution patterns of PAHs indicated similar sources. In addition, although light fractions had the mass fraction by weight of less than 5%, they contributed almost 75% of the total PAHs in the soil. PAH concentrations of all sub fractions showed positive correlation with their TOC contents. Altogether, coal and coal-derived partic…
Appraisal of geodynamic inversion results: a data mining approach
2016
Abstract Bayesian sampling based inversions require many thousands or even millions of forward models, depending on how nonlinear or non-unique the inverse problem is, and how many unknowns are involved. The result of such a probabilistic inversion is not a single ‘best-fit’ model, but rather a probability distribution that is represented by the entire model ensemble. Often, a geophysical inverse problem is non-unique, and the corresponding posterior distribution is multimodal, meaning that the distribution consists of clusters with similar models that represent the observations equally well. In these cases, we would like to visualize the characteristic model properties within each of these…
LKS-92 Coordinates Transformation to ITRF2000
2014
LKS-92 is Latvian geodetic coordinate system used as an EUREF89 realization in Latvia. LKS-92 is official coordinate system for procuring of essential geospatial data. For aeronautical and other purposes ITRF2000 is used in publication of geospatial data. Research is done to obtain transformation parameters from LKS-92 realization epoch 1992.75 through LatPos to ITRF2000 epoch 2000.00. Valuation of two different coordinate adjustment strategies and accuracy of parameters is done. Results of research could be used for transformation from LKS-92 to ITRF2000 for all kind of geospatial data.
Happy Aged People Are All Alike, While Every Unhappy Aged Person Is Unhappy in Its Own Way
2011
Aging of the world’s population represents one of the most remarkable success stories of medicine and of humankind, but it is also a source of various challenges. The aim of the collaborative cross-cultural European study of adult well being (ESAW) is to frame the concept of aging successfully within a causal model that embraces physical health and functional status, cognitive efficacy, material security, social support resources, and life activity. Within the framework of this project, we show here that the degree of heterogeneity among people who view aging in a positive light is significantly lower than the degree of heterogeneity of those who hold a negative perception of aging. We base…
Interactive Process Mining in Type 2 Diabetes Mellitus
2020
This chapter is a descriptive use case of the Interactive Process Mining paradigm in one of the most significant problems of healthcare in relation to the management of chronic conditions, Type 2 Diabetes Mellitus. The chapter firstly performs a comprehensive description of the disease, its origins, evolution and standard of care, to thereafter adapt the concepts of Interactive Process Mining to trigger big quantities of heterogeneous observational data into actionable information for patient’s evaluations. The use case is focused in the analysis of Glycated Hemoglobin, a major indicator of blood glucose levels and a key factor in the management of the disease. The chapter is a preliminary …