Search results for "Mir"

Potential miRNAs involved in molecular pathways mediating the anticancer effects of short term starvation in breast cancer cells treated with doxorub…

2017

Background: In recent years, increasing evidences showed that several types of dietary approaches restricting food intake, including Short Term Starvation (STS), may exert a protective role against aging and other age-related pathologies as well as cancer. Interestingly, the dietary restriction showed significant anticancer effects able to prevent cancer onset, slow its progression and improve therapy response. Since recent studies showed that miRNAs may modulate sensibility/resistance to antiblastic therapy, the aim of our study was to investigate the STS-induced molecular changes in breast cancer cells treated with doxorubicin, focusing our attention on miRNA expression profile. Materials…

ON THE ASYMPTOTIC DISTRIBUTION OF BARTLETT'S Up-STATISTIC

1985

Abstract. In this paper the asymptotic behaviour of Bartlett's Up-statistic for a goodness-of-fit test for stationary processes, is considered. The asymptotic distribution of the test process is given under the assumption that a central limit theorem for the empirical spectral distribution function holds. It is shown that the Up-statistic tends to the supremum of a tied down Brownian motion. By a counterexample we refute the conjecture that this distribution is in general of the Kolmogorov-Smirnov type. The validity of the central limit theorem for the spectral distribution function is then discussed. Finally a goodness-of-fit test for ARMA-processes based on the estimated innovation sequen…

Testing Goodness-of-Fit with the Kernel Density Estimator: GoFKernel

2015

To assess the goodness-of-fit of a sample to a continuous random distribution, the most popular approach has been based on measuring, using either L∞ - or L2 -norms, the distance between the null hypothesis cumulative distribution function and the empirical cumulative distribution function. Indeed, as far as I know, almost all the tests currently available in R related to this issue (ks.test in package stats, ad.test in package ADGofTest, and ad.test, ad2.test, ks.test, v.test and w2.test in package truncgof) use one of these two distances on cumulative distribution functions. This paper (i) proposes dgeometric.test, a new implementation of the test that measures the discrepancy between a s…

Casimir-Polder forces, boundary conditions and fluctuations

2008

We review different aspects of the atom-atom and atom-wall Casimir-Polder forces. We first discuss the role of a boundary condition on the interatomic Casimir-Polder potential between two ground-state atoms, and give a physically transparent interpretation of the results in terms of vacuum fluctuations and image atomic dipoles. We then discuss the known atom-wall Casimir-Polder force for ground- and excited-state atoms, using a different method which is also suited for extension to time-dependent situations. Finally, we consider the fluctuation of the Casimir-Polder force between a ground-state atom and a conducting wall, and discuss possible observation of this force fluctuation.

N-Heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action

2016

Pharmacological effects of biologically active “small molecules” can be improved by their targeted modification, which affects drug delivery and interaction with tumor cells and microorganisms. We aimed to evaluate anticancer and antimicrobial activity of lipid-like choline derivatives modified via simultaneous introduction of tetrahydro(iso)quinoline based pharmacophore system at nitrogen atom and long chain alkyl substituent at oxygen atom. Target compounds were synthesized under phase-transfer catalysis conditions followed by quaternization, and evaluated for cytotoxicity and NO-generation ability on HT-1080 and MG-22A tumor cell lines and NIH 3T3 normal mouse fibroblasts, and screened f…

A validated energy model of a solar dish-Stirling system considering the cleanliness of mirrors

2020

Solar systems based on the coupling of parabolic concentrating collectors and thermal engines (i.e. dish-Stirling systems) are among the most efficient generators of solar power currently available. This study focuses on the modelling of functioning data from a 32 kWe dish-Stirling solar plant installed at a facility test site on the University of Palermo campus, in Southern Italy. The proposed model, based on real monitored data, the energy balance of the collector and the partial load efficiency of the Stirling engine, can be used easily to simulate the annual energy production of such systems, making use of the solar radiation database, with the aim of encouraging a greater commercialisa…

Breve fenomenologia del desiderio

2014

Review and a New Subfamily Placement of the Plant Bug GenusIsometocorisCarvalho and Sailer, 1954 (Hemiptera: Heteroptera: Miridae), with the Descript…

2015

Abstract The genus Isometocoris Carvalho and Sailer is reviewed and I. penicillus, new species, from Brazil is described. Diagnoses of the genus and included species I. blantoni Carvalho and Sailer and I. penicillus, n. sp., are given; a color adult habitus photo of both Isometocoris species, male genitalic drawings of Isometocoris penicillus n. sp., and scanning electron micrographs of selected structures of I. blantoni are provided; and an identification key is given to help distinguish the two included species. Isometocoris is transferred from the subfamily Psallopinae to the Cylapinae, where it is placed in the tribe Fulviini. Psallopinae is reduced to tribal level (Psallopini, new stat…

Temperature dependence of the magnetic Casimir-Polder interaction

2009

We analyze the magnetic dipole contribution to atom-surface dispersion forces. Unlike its electrical counterpart, it involves small transition frequencies that are comparable to thermal energy scales. A significant temperature dependence is found near surfaces with a nonzero DC conductivity, leading to a strong suppression of the dispersion force at T > 0. We use thermal response theory for the surface material and discuss both normal metals and superconductors. The asymptotes of the free energy of interaction and of the entropy are calculated analytically over a large range of distances. Near a superconductor, the onset of dissipation at the phase transition strongly changes the interac…

Non-Equilibrium Thermodinamic analysis of rotating counterflow superfluid turbulence

2008

Two alternative evolution equations for the vortex line density L in counterflow superfluid turbulence in 4He were proposed by Vinen in 1958. These equations was recently generalized to counterflow superfluid turbulence in rotating containers. Here, according with the formalism of Non-Equilibrium Thermodynamics, the compatibility between the alternative Vinen equation as evolution equation for the vortex line density in rotating counterflow turbulence and the velocity of the superfluid component is studied. From the compatibility request a new term dependent on the anisotropy of the tangle arises.