Search results for "Mito"

Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells

2014

Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most frequently mutated tumor suppressor gene in cancers and mutant p53 protein (mutp53) can acquire gain of function (GOF) strongly contributing to malignancy. Studies thus far have not shown p53-GOF in osteosarcoma. Here, we investigated TP53 gene status/role in 3AB-OS cells-a highly aggressive CSC line previously selected from human osteosarcoma MG63 cells-to evaluate its involv…

Atypical Phacomatosis Pigmentokeratotica as the Expression of a Mosaic RASopathy With the BRAF-Glu586Lys Mutation

2016

Redox signaling and histone acetylation in acute pancreatitis

2011

Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines in the activation phase of inflammation, particularly through mitogen-activated protein kinases (MAPKs), nuclear factor-κB (NF-κB), and signal transducers and activators of transcription (STAT) pathways. In contrast, histone deacetylases (HDACs) and protein phosphatases are mainly involved in the attenuation phase of inflammation. The role of reactive oxygen species (ROS) in the inflammatory cascade is much more important than expected. Mitochondrial ROS act as signal-transducing molecules that trigger proinflammatory cytokine production via inflammasome-independent and inflammasome-dependent pathways. …

Palaephati Scriptoris Graeci Opusculum De non Credendis Fabulosis narrationibus / Interprete Philippo Phasianino Bononiensi

1515

Sig. A-C8, D4 Text amb postil·les marginals. - Minúscules per a inicials

Doña Marina, otra vez. Las contradicciones de la propuesta de Inés M. Stranger en Malinche

2019

La obra Malinche, de Inés M. Stranger, configura una propuesta de reescritura de la Malinche como figura mítica incorporada al imaginario cultural hispanoamericano, que perdura hasta la actualidad. Es común el empleo de esta figura en diversos autores contemporáneos que abordan cuestiones relativas a las identidades nacionales latinoamericanas en sus textos. Algunas autoras han utilizado, además, este personaje para elaborar una reescritura del mito con perspectiva crítica, en relación al modo en que este califica a un modelo de mujer indígena con toda una serie de significados negativos. La obra de Inés M. Stranger a la que se dedica el presente trabajo tiene unos presupuestos similares. E…

Sexism, romantic love and gender inequality. A study of Latin American adolescents living in Spain

2019

Este trabajo examina el papel de los factores sociodemográficos como determinantes de las creencias y actitudes sexistas y las percepciones distorsionadas sobre el amor romántico, y analiza la relación entre el sexismo hostil y el sexismo benevolente y las creencias en mitos del amor romántico, según el Índice de Desigualdad de Género (idg), en una muestra de 203 adolescentes latinoamericanos residentes en Valencia (España). This paper examines the role of socio-demographic factors determining both sexist beliefs and attitudes and distorted perceptions of romantic love. Moreover, the relationship between hostile and benevolent sexism, and the belief in myths about romantic love is analyzed …

Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans

2021

Abstract Methylation of carbon‐5 of cytosines (m5C) is a post‐transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been studied, the impact of the global cytosine‐5 methylome on development, homeostasis and stress remains unknown. Here, using Caenorhabditis elegans, we generated the first organism devoid of m5C in RNA, demonstrating that this modification is non‐essential. Using this genetic tool, we determine the localisation and enzymatic specificity of m5C sites in the RNome in vivo. We find that NSUN‐4 acts as a dual rRNA and tRNA methyltransferase in C. elegans mitochondria. In agreement with leucine and proline bein…

The Elicitor Cryptogein Blocks Glucose Transport in Tobacco Cells

2002

Abstract Cryptogein is a 10-kD protein secreted by the oomycetePhytophthora cryptogea that induces a hypersensitive response on tobacco (Nicotiana tabacum var. Xanthi) plants and a systemic acquired resistance against various pathogens. The mode of action of this elicitor has been studied using tobacco cell suspensions. Our previous data indicated that within minutes, cryptogein signaling involves various events including changes in ion fluxes, protein phosphorylation, sugar metabolism, and, eventually, cell death. These results suggested that transport of sugars could be affected and, thus, involved in the complex relationships between plant and microorganisms via elicitors. This led us to…

Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake.

2006

0012-1797 (Print) Journal Article Research Support, Non-U.S. Gov't; The ability for the brain to sense peripheral fuel availability is mainly accomplished within the hypothalamus, which detects ongoing systemic nutrients and adjusts food intake and peripheral metabolism as needed. Here, we hypothesized that mitochondrial reactive oxygen species (ROS) could trigger sensing of nutrients within the hypothalamus. For this purpose, we induced acute hypertriglyceridemia in rats and examined the function of mitochondria in the hypothalamus. Hypertriglyceridemia led to a rapid increase in the mitochondrial respiration in the ventral hypothalamus together with a transient production of ROS. Cerebral…

The Parasitic Colonization of the Horny Layer in Tinea Versicolor

1972

Observations of vertical sections and of tape strippings of areas infested with tinea versicolor indicate that because of their dimorphic state, these parasites can colonize the horny layer. Mycelial hyphae progress downwards into the intercellular spaces of the horny cells where they feed on nonkeratinous substances and extrude proliferating yeast cells which form clusters in nest-like cavities. The yeast-mycelial conversion gives rise to new mycelial hyphae and the cycle is complete. The parasites are actually lodged in tunnels and nests hollowed out in the horny layer. A dynamic balance between the cycle of the parasites and the renewal rate of the horny layer is responsible for the long…