Search results for "Mitophagie"
showing 2 items of 2 documents
Mitophagy in myeloid cells : role in infection with gram-negative bacteria
2017
Sepsis and related organ dysfunctions remain a leading cause of mortality in intensive care units. Increasing evidences have shed light on an unexpected link between mitochondria and immune cell functions. Alterations in mitochondrial functions have been reported in peripheral blood cells in sepsis. We hypothesize here that mitophagy might impact on phagocyte functions in the context of bacterial infection. Mitophagy is a mitochondria-dedicated autophagy that governs the elimination of dysfunctional mitochondria. We demonstrated here in vivo and in vitro that macrophages exposed to Gram-negative bacteria or their cell wall component LPS display a marked inhibition of mitophagy that constitu…
Mitochondrial dysfunction and host immune response during pneumococcal pneumonia : impact of mechanical ventilation?
2020
Lung damage induced by mechanical ventilation (MV) worsens the prognosis of pneumonia. Mitochondrial dysfunctions could account for such deleterious effects. Accordingly, data obtained from both in vitro and in vivo experimental studies, as well as in ventilated patients with acute respiratory distress syndrome, show that mitochondrial alarmins, especially mitochondrial DNA, are released in the alveolar compartment as a result of the cyclic stretch, and could thus represent one link between the mechanical insult and the sterile inflammation leading to VILI (ventilator-induced lung injury). In rabbits, we show herein that adverse and prolonged MV worsens the prognosis of pneumococcal pneumon…