Search results for "Mod"
showing 10 items of 39605 documents
Nobili committenti: alle origini delle architetture neocarnilivaresche in Sicilia
2006
Il testo ripercorre i momenti salienti della riscoperta nel XIX secolo delle architettura quattro-cinquecentesche di Matteo Carnilivari a Palermo. Vengono così passati in rassegna e descritti gli episodi più significativi, con la pubblicazione anche di disegni d'archivio inediti, che sono posti in relazione al gusto corrente per l'epoca a Palermo ovvero alla particolare attenzione al rinascimento locale.
L’architettura neogotica nella Sicilia occidentale nella prima metà del XIX secolo: le ragioni degli artisti e il ruolo della committenza
2008
L'intervento ha preso in esame i principali esempi di architettura neogotica a Palermo nella prima metà del XIX secolo provando a rilevare al di là del ruolo degli architetti anche il contributo della committenza. Si è cercato di dimostrare come la committenza, dai Borbone agli esponenti della nobiltà locale, pur con intenti divergenti, mirassero ad esiti analoghi che giustificano lo straordinario fiorire di architetture neomedievali a Palermo con datazioni di notevole precocità rispetto agli episodi continentali.
Une singulière « invention » à Palerme a la fin du XIXe siècle : le mobilier néo-normand
2006
Il saggio ha affrontato un argomento pregnante per la culturale palermitana in stretta connessione con quanto accade, per diverse ragioni, in altre regioni europee, ovvero la riscoperta del medioevo normanno come fonte di ispirazione per il gusto e fondamenta di ipotesi ideologiche storiche e politiche che si traducono in fatti d’arte. Nel caso specifico è stata illustrata la singolarissima esperienza di un “intellettuale” palermitano quasi del tutto dimenticato, Andrea Onufrio, che sulla scorta di questo clima produce arredi handmade con una tecnica da Art & Craft che vuole proprio opporsi alla realizzazione industriale e banalmente seriale degli stessi in funzione di una nuova “aristocraz…
Optisks čukstošās galerijas modu mikrorezonatora mitruma sensors
2020
Šajā bakalaura darbā tiek pētīti čukstošās galerijas modu (ČGM) mikrorezonatori un to pielietojums gaisa mitruma kontrolei un mērīšanai. ČGM rodas, kad gludas virsmas optiskajos dobumos notiek konstruktīva interference. Rezultātā rezonatorā paliek tikai noteikti viļņu garumi, kas atkarīgi no rezonatora izmēra un laušanas koeficienta. Līdz ar to, ja kāds no šiem parametriem gaisa mitruma izmaiņu dēļ mainās, rezonatoru var izmantot kā mitruma sensoru. Eksperimentam izvēlēts glicerīna piliens, kurā ČGM rezonanses ierosinātas ar skenējamu pusvadītāju lāzeru. Izveidota eksperimentāla iekārta, ar kuru var pētīt šāda veida mitruma sensoru. Rezultātā iegūta jutība vidēji 4,14 nm/% RH lāzera viļņa g…
Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-α blockers: The GI…
2007
OBJECTIVE: To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics. METHODS: Retrospective national study of 14 academic tertiary referral rheumatology medical centers. RA patients with a Disease Activity Score (DAS28) > 3.2 were defined as having active disease and could start TNF-alpha blockers. All patients received one TNF-alpha blocker plus methotrexate (10-20 mg/wk). At the third month the patients were categorized as responders or nonresponders, based on improvement of at least 0.25 of the Health Assessment Questionnaire (HAQ).…
HMG-CoA reductase inhibitors (statins) as anticancer drugs (Review)
2005
Apart from their lipid lowering activity, HMG-CoA reductase inhibitors (statins) impair numerous cellular functions associated with metastasis, e.g. gene expression, angiogenesis, cell adhesion, cell motility and invasiveness. Furthermore, statins have impact on apoptotic cell death and modulate cellular susceptibility to cell killing by anticancer drugs and ionizing radiation. Part of the effects provoked by statins are due to the inhibition of the prenylation of low molecular weight GTPases, in particular Ras and Rho, which play key roles in signaling evoked by stimulation of cell surface receptors. C-terminal lipid modification of Ras/Rho GTPases is essential for their correct intracellu…
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…