Search results for "Moda"
showing 10 items of 1753 documents
New site-specific bioconjugation strategies and their application to the development of molecular imaging agents for cancer diagnostic
2018
The preparation of targeted imaging agents suitable for cancer diagnostic involves the coupling of an imaging probe to a vector, generally a protein, able to specifically target cancerous tissues. Unfortunately, this bioconjugation step is often problematic. Indeed, proteins present a large variety of reactive functions that can potentially interfere with the coupling reaction. The purpose of this work is the design of innovative selective bioconjugation strategies that can facilitate the synthesis of molecular imaging agents.Our research led to the development of a simple and efficient approach allowing the modification of a protein with a fluorophore by using a site-specific bioconjugatio…
Side effect management during immune checkpoint blockade using CTLA-4 and PD-1 antibodies for metastatic melanoma – an update
2020
CTLA-4 and PD-1 play a key role in tumor-induced downregulation of lymphocytic immune responses. Immune checkpoint inhibitors have been shown to alter the immune response to various cancer types. Anti-CTLA-4 and anti-PD-1 antibodies affect the interaction between tumor, antigen-presenting cells and T lymphocytes. Clinical studies of the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibodies nivolumab and pembrolizumab have provided evidence of their positive effects on overall survival in melanoma patients. Combined treatment using ipilimumab and nivolumab has been shown to achieve five-year survival rates of 52 %. Such enhancement of the immune response is inevitably associated with …
The communication of melancholy, grief, and fear in dance with and without music
2020
Professional dancers were video recorded dancing with the intention of expressing melancholy, grief, or fear. We used these recordings as stimuli in two studies designed to investigate the perception and sociality of melancholy, grief, and fear expressions during unimodal (dancing in silence) and multimodal (dancing to music) conditions. In Study 1, viewers rated their perceptions of social connection among the dancers in these videos. In Study 2, the same videos were coded for the amount of time that dancers spent in physical contact. Results revealed that dancers expressing grief and fear exhibited more social interactions than dancers expressing melancholy. Combined with the findings of …
Creating Digital Musical Instruments With and for Children: Including Vocal Sketching as a Method for Engaging in Codesign
2020
International audience; A class of master of science students and a group of preschool children codesigned new digital musical instruments based on workshop interviews involving vocal sketching, a method for imitating and portraying sounds. The aim of the study was to explore how the students and children would approach vocal sketching as one of several design methods. The children described musical instruments to the students using vocal sketching and other modalities (verbal, drawing, gestures). The resulting instruments built by the students were showcased at the Swedish Museum of Performing Arts in Stockholm. Although all the children tried vocal sketching during preparatory tasks, few …
UBFC-Phys: A Multimodal Database For Psychophysiological Studies of Social Stress
2021
As humans, we experience social stress in countless everyday-life situations. Giving a speech in front of an audience, passing a job interview, and similar experiences all lead us to go through stress states that impact both our psychological and physiological states. Therefore, studying the link between stress and physiological responses had become a critical societal issue, and recently, research in this field has grown in popularity. However, publicly available datasets have limitations. In this article, we propose a new dataset, UBFC-Phys, collected with and without contact from participants living social stress situations. A wristband was used to measure contact blood volume pulse (BVP…
Propiedad Intelectual en Internet: los retos de su tutela judicial
2017
Bajo el título “Propiedad Intelectual en Internet. Los retos de su tutela judicial”, el objetivo de la presente tesis doctoral es analizar si, en el estado actual, nuestro ordenamiento jurídico ofrece mecanismos de tutela suficientes y adecuados para proteger los derechos de propiedad intelectual frente a las infracciones cometidas en Internet. Este trabajo de investigación toma como punto de partida la hipótesis de que, el Derecho nacional, junto al Derecho de la Unión Europea, han configurado en los últimos años un sistema que permite obtener la protección de los derechos de propiedad intelectual ante los tribunales españoles; ahora bien, la eficiencia de esta tutela se plantea como un re…
¿En qué aspectos es más deficiente la alfabetización científica del alumnado de Bachillerato?
2020
Resumen: En el presente artículo se realiza un estudio sobre diversas definiciones de alfabetización científica.Basándonos en ellas se elabora una serie de indicadores de la misma y se presenta un diseño experimental que pretende evaluar el grado de alfabetización científica del alumnado del bachillerato científico tecnológico (GCT) y el de humanidades y ciencias sociales (GHS) en dichos aspectos, comparándolos entre sí. Los resultados ponen de manifiesto que conceptualmente el alumnado del GCT tiene un mayor grado de conocimiento científico que el alumnado GHS. En cambio, llama la atención que ante aspectos actitudinales y de relaciones cienciatecnología-sociedad no existen diferencias sig…
Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy
2013
The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…
Multimodal approaches to the treatment of hepatocellular carcinoma.
2008
The prevalence of hepatocellular carcinoma in Europe and the US is increasing and is currently the leading cause of death in patients with cirrhosis. Surveillance programs for patients with cirrhosis aim to detect tumors at an early stage, when the greatest therapeutic benefits can be achieved. Curative treatments for early-stage tumors include liver transplantation, resection and percutaneous ablation. Transarterial chemoembolization (TACE) and sorafenib can improve survival for patients with intermediate and advanced tumors, respectively. In clinical practice, combination therapies are often used, despite limited evidence to support this approach from randomized controlled trials. Combina…
Future perspectives in hepatocellular carcinoma.
2010
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Due to late diagnosis and advanced underlying liver cirrhosis, only limited treatment options with marginal clinical benefits have been available in up to 70% of patients. However, major progress has been achieved with regard to surveillance, early diagnosis, and multimodal treatment approaches during the last years leading to an improvement in prognosis. Particularly, the increasing knowledge of molecular hepatocarcinogenesis today provides the opportunity for targeted therapy. The multikinase inhibitor sorafenib has broadened the therapeutic horizon for patients with advanced disease and is current…